{"id":1228,"date":"2018-04-25T09:08:48","date_gmt":"2018-04-25T09:08:48","guid":{"rendered":"http:\/\/sites.unimi.it\/SSPA\/?page_id=1228"},"modified":"2018-04-25T09:08:48","modified_gmt":"2018-04-25T09:08:48","slug":"doriano-lamba","status":"publish","type":"page","link":"https:\/\/sites.unimi.it\/SSPA\/2018\/doriano-lamba\/","title":{"rendered":"Doriano Lamba"},"content":{"rendered":"

[et_pb_section admin_label=”section”][et_pb_row admin_label=”row”][et_pb_column type=”1_4″][et_pb_image admin_label=”Image” src=”http:\/\/sites.unimi.it\/SSPA\/sspa2018\/wp-content\/uploads\/sites\/3\/2018\/04\/SPPA_2018_Photo_DLamba_09.04.2018.jpg” show_in_lightbox=”off” url_new_window=”off” use_overlay=”off” animation=”left” sticky=”off” align=”left” force_fullwidth=”off” always_center_on_mobile=”on” use_border_color=”off” border_color=”#ffffff” border_style=”solid”]
\n[\/et_pb_image][\/et_pb_column][et_pb_column type=”3_4″][et_pb_text admin_label=”Text” background_layout=”light” text_orientation=”left” use_border_color=”off” border_color=”#ffffff” border_style=”solid”]
\nDoriano Lamba<\/strong> – Dr. Doriano Lamba, obtained a degree in Chemistry (1980) University of Rome \u201cLa Sapienza\u201d and a PhD in Biophysics (1988) Astubury Dept of Biophysics, Leeds University (UK). Post Doc in Protein Crystallography (1993-1996) at MPI \u2013 Biochemistry,Muenchen (DE).
\nDeputy Head of the Trieste Outstation of IC-CNR (2010-2018). Guest Scientist at ICGEB and associated Senior Scientist at ISAS, Trieste (1997-2005).
\nAdjunct professor (2010-2017) in Structural Biology at SNS, Pisa. Adjunct professor (2017-) in Synchrotron Radiation Applications in Structural Biology \u2013 Universit\u00e0 degli Studi di Trieste.
\nItalian delegate INPEC (2009-). Member (2013-) of the steering committee CRG-IN13 CNR-ILL, Grenoble (FR), and president (2012-) of the scientific panel review committee CRG GILDA \u2013CNR, ESRF, Grenoble(FR).
\nMember of the Italian delegation -European Synchrotron User Organization (2016-).
\nDr. Lamba\u2019s research fields are biochemistry, biophysics, biocrystallography and structure-based drug design.
\nHis career has been constantly centered on the structure-activity-function relationships of key biomedical protein targets implicated in several physiological and pathological states (coagulation, fibrinolysis, Alzheimer\u2019s disease, neuropathic chronic pain).
\nHe is partner of several projects funded by the Italian Ministry of Research and EU, and actively collaborates with a number of pharmaceutical companies. He has authored 113 publications on international ISI journals with an H index of 26 (ISI WOS).
\nSelected Publications(2014-2018)
\n1.Nepovimova E., Uliassi E., Korabecny J., Pe\u00f1a-Altamira L. , Samez S., Pesaresi A., Garcia G.E., Bartolini M., Andrisano V.,Bergamini C., Fato R., Lamba D., Roberti M., Kuca K., Monti B., Bolognesi M.L. \u201cMultitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-beta aggregation and to exert anticholinesterase and antioxidant effects\u201d J. Med. Chem. 57, 8576\u20138589 (2014)
\n2.Paoletti F., Malerba F., Bruni E. P., Lamba D., Cattaneo A. \u201cA comparative analysis of the structural, functional and biological differences between mouse and human nerve growth factor\u201d Biochimica et Biophysica Acta \u2013 Proteins and Proteomics 1854, 187-197 (2015)
\n3.Covaceuszach S., Konarev P. V., Cassetta, A., Paoletti F., Svergun D.I., Lamba D., Cattaneo A. \u201cThe conundrum of the \u201chigh affinity\u201d NGF binding sites formation unveiled?\u201d Biophysical J. 108, 687-697 (2015)
\n4.Bozzi M., Cassetta A., Covaceuszach S., Bigotti M.G., Bannister S., H\u00fcbner W., Sciandra F., Lamba D., Brancaccio A. \u201cThe Structure of the T190M Mutant of Murine a-Dystroglycan at High Resolution: Insight into the Molecular Basis of a Primary Dystroglycanopathy. PLos ONE 10, e0124277 (2015)
\n5.Malerba, F.; Paoletti, F.; Bruni E.B.; Materazzi, S.; Nassini, R.; Coppi, E.; Patacchini, R.; Capsoni, S.; Lamba, D.; Cattaneo, A. \u201cFunctional characterization of human proNGF and NGF mutants: identification of NGF P61SR100E as a \u2018painless\u2019 lead investigational candidate for therapeutic applications\u201d PLos ONE 10, e0136425 (2015)
\n6.Zha X., Lamba D., Zhang L., Lou Y., Zhou C., Xua C., Kang D., Chen L., Xu Y., Zhang L., De Simone A., Samez S., Pesaresi A., Stojan J., Garcia M., Egea J., Andrisano V., Bartolini M. \u201cNovel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer\u2019s Disease:Design, Synthesis, Biological Evaluation and X-ray Crystallography\u201d J. Med. Chem. 59, 114-131 (2016)
\n7.Paoletti F., De Chiara C., Kelly G., Covaceuszach S., Malerba F., Yan R., Lamba D., Cattaneo A., Pastore A. \u201cConformational rigidity within plasticity promotes differential target recognition of Nerve Growth Factor\u201d. Frontiers in Molecular Biosciences 3,83 (2016)
\n8.Cassetta A., Stojan J., Krastanova I., Kristan K., Brunskole \u0160vegelj M., Lamba D., Lani\u0161nik Ri\u017ener T. \u201cStructural basis for inhibition of 17\u03b2-hydroxysteroid dehydrogenases by phytoestrogens: the case of fungal 17\u03b2-HSDcl\u201d The Journal of Steroid Biochemistry and Molecular Biology 171, 80-93 (2017)
\nPatent
\nCattaneo A., Covaceuszach S., Lamba D. Method for the humanization of antibodies and humanized antibodies thereby obtained”. Patent WO\/2005\/061540. Licensed to: Bioxell SpA (2005); Pangenetics B.V.(2006); Abbott (2009); Glenmark Pharma (2010).
\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section admin_label=”sponsor” global_module=”765″ transparent_background=”off” allow_player_pause=”off” inner_shadow=”off” parallax=”off” parallax_method=”on” make_fullwidth=”off” use_custom_width=”off” width_unit=”off” make_equal=”off” use_custom_gutter=”off” fullwidth=”on” specialty=”off” disabled=”off”][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

[et_pb_section admin_label=”section”][et_pb_row admin_label=”row”][et_pb_column type=”1_4″][et_pb_image admin_label=”Image” src=”http:\/\/sites.unimi.it\/SSPA\/sspa2018\/wp-content\/uploads\/sites\/3\/2018\/04\/SPPA_2018_Photo_DLamba_09.04.2018.jpg” show_in_lightbox=”off” url_new_window=”off” use_overlay=”off” animation=”left” sticky=”off” align=”left” force_fullwidth=”off” always_center_on_mobile=”on” use_border_color=”off” border_color=”#ffffff” border_style=”solid”] [\/et_pb_image][\/et_pb_column][et_pb_column type=”3_4″][et_pb_text admin_label=”Text” background_layout=”light” text_orientation=”left” use_border_color=”off” border_color=”#ffffff” border_style=”solid”] Doriano Lamba – Dr. Doriano Lamba, obtained a degree in Chemistry (1980) University of Rome \u201cLa Sapienza\u201d and a PhD in Biophysics (1988) Astubury Dept of Biophysics, Leeds University (UK). […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/sites.unimi.it\/SSPA\/2018\/wp-json\/wp\/v2\/pages\/1228"}],"collection":[{"href":"https:\/\/sites.unimi.it\/SSPA\/2018\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.unimi.it\/SSPA\/2018\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.unimi.it\/SSPA\/2018\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.unimi.it\/SSPA\/2018\/wp-json\/wp\/v2\/comments?post=1228"}],"version-history":[{"count":0,"href":"https:\/\/sites.unimi.it\/SSPA\/2018\/wp-json\/wp\/v2\/pages\/1228\/revisions"}],"wp:attachment":[{"href":"https:\/\/sites.unimi.it\/SSPA\/2018\/wp-json\/wp\/v2\/media?parent=1228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}