Bernardi Group

Recent Publications

Rational-differential design of highly specific glycomimetic ligands: Targeting DC-SIGN and excluding Langerin recognition
V. Porkolab; E. Chabrol; N. Varga; S. Ordanini; I. Sutkeviciute; M. Thepaut; M. J. Garcia-Jimenez; E. Girard; P. M. Nieto; A. Bernardi; F. Fieschi ACS Chem. Biol. 2017, DOI: 10.1021/acschembio.7b00958

Observation of a Tricyclic[4.1.0.02,4]heptane During a Michael Addition-Ring Closure Reaction and a Computational Study on Its Mechanism of Formation M. Farren-Dai; J. R. Thompson; A. Bernardi; C. Colombo; A. J. Bennet
J. Org. Chem. 2017, 82, 12511

From optimized monovalent ligands to size-controlled dendrimers: an efficient strategy towards high-activity DC-SIGN antagonists S. Ordanini; G. Goti; A. Bernardi
Can. J. Chem. 2017, 95, 881

Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads I. D'Annessa, S. Sattin, J. Tao, M. Pennati, C. Sànchez-Martìn, E. Moroni, A. Rasola, N. Zaffaroni, D.A. Agard, A. Bernardi, and G. Colombo
Chem. Eur. J. 2017, 23, 5188

Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics
Heggelund, J. E.; Mackenzie, A.; Martinsen, T.; Heim, J. B.; Cheshev, P.; Bernardi, A.; Krengel, U.
Sci. Rep. 2017, 7 (1), 2326

Glyco-functionalized dinuclear rhenium(I) complexes for cell imaging  A. Palmioli, A. Aliprandi, D. Septiadi, M. Mauro, A. Bernardi, L. De Cola and M. Panigati
Org. Biomol. Chem. 2017, 15, 1686-1699

Stereoselective innovative synthesis and biological evaluation of new real carba analogues of minimal epitope Manα(1,2)Man as DC-SIGN inhibitors V. Bordoni; V. Porkolab; S. Sattin; M. Thépaut; I. Frau; L. Favero; P. Crotti; A. Bernardi; F. Fieschi; V. Di Bussolo
RSC Adv. 2016, 6, 89578

A new surface plasmon resonance assay for in vitro screening of mannose-binding lectin inhibitors M. Stravalaci; D. De Blasio; F. Orsini; C. Perego; A. Palmioli; G. Goti; A. Bernardi; M.-G. De Simoni; M. Gobbi 
J. Biomol. Screening 2016, 21, 749

Pseudo-Mannosylated DC-SIGN Ligands as Immunomodulants A. Berzi; S. Ordanini; B. Joosten; D. Trabattoni; A. Cambi; A. Bernardi and M. Clerici
Sci. Rep. 2016, 6, 35373

Synthesis and evaluation of influenza A viral neuraminidase candidate inhibitors based on a bicyclo[3.1.0]hexane scaffold C. Colombo; M.B. Pinto; A. Bernardi and A.J. Bennet
Org. Biomol. Chem. 2016, 14, 6539- 6553

Synthesis of functionalized 2-(4-hydroxyphenyl)-3-methylbenzofuran allosteric modulators of Hsp90 activity S. Sattin; M. Panza; F. Vasile; F. Berni; G. Goti; J. Tao; D. Agard; G. Colombo; A. Bernardi
Eur J Org Chem 2016, 2016, 3349

Pharmacological inhibition of mannose binding lectin ameliorates neurobehavioral dysfunction following experimental traumatic brain injury D. De Blasio; S. Fumagalli; L. Longhi; F. Orsini; A. Palmioli; M. Stravalaci; G. Vegliante; E. Zanier; A. Bernardi; M. Gobbi and M.G. De Simoni
J Cereb Blood Flow Metab, 2017, 37 (3), 938-950

Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands G. Vettoretti; E. Moroni; S. Sattin; J. Tao; D. A. Agard; A. Bernardi; G. Colombo
Sci Rep 2016, 6, 23830

A new surface plasmon resonance assay for in vitro screening of mannose-binding lectin inhibitors M. Stravalaci; D. De Blasio; F. Orsini; C. Perego; A. Palmioli; G. Goti; A. Bernardi; M.-G. De Simoni and M. Gobbi
J. Biomol. Screen., 2016, 21(7), 749–757

Solution behaviour of amphiphilic glycodendrimers with a rod-like core S. Ordanini; G. Zanchetta; V. Porkolab; C. Ebel; F. Fieschi; I. Guzzetti; D. Potenza; A. Palmioli; Č. Podlipnik; D. Meroni and A. Bernardi
Macromol. Biosci. 2016, 6,896-905

Scaffold Optimisation of Tetravalent Antagonists of the Mannose Binding Lectin G. Goti; A. Palmioli; M. Stravalaci; S. Sattin; M. G. De Simoni; M. Gobbi; A. Bernardi
Chem. Eur. J. 2016, 22, 3686

Glycoconjugates and Glycomimetics as Microbial Anti-Adhesives S. Sattin; A. Bernardi
Trends Biotechnol. 2016, 34, 483

Detection and quantitative analysis of two independent binding modes of a small ligand responsible for DC-SIGN clustering C. Guzzi; P. Alfarano; I. Sutkeviciute; S. Sattin; R. Ribeiro-Viana; F. Fieschi; A. Bernardi; J. Weiser; J. Rojo; J. Angulo; P. M. Nieto
Org Biomol Chem 2016, 14, 335

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods S. Ordanini; N. Varga; V. Porkolab; M. Thepaut; L. Belvisi; A. Bertaglia; A. Palmioli; A. Berzi; D. Trabattoni; M. Clerici; F. Fieschi and A. Bernardi
Chem. Commun. 2015, 51, 3816-3819

Critical role and therapeutic control of the lectin pathway of complement activation in an abortion prone mouse mating M. Petitbarat; P. Durigutto; P. Macor; R. Bulla; A. Palmioli; A. Bernardi; M.-G. De Simoni; N. Ledee; G. Chaouat and F. Tedesco
J. Immunol 2015, 195, 5602-5607

Carbohydrates: A phenol sandwich fights diabetes A. Bernardi; S. Sattin
Nat Chem Biol 2015, 11, 635

Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands S. Sattin; J. Tao; G. Vettoretti; E. Moroni; M. Pennati; A. Lopergolo; L. Morelli; A. Bugatti; A. Zuehlke; M. Moses; T. Prince; T. Kijima; K. Beebe; M. Rusnati; L. Neckers; N. Zaffaroni; D. A. Agard; A. Bernardi; G. Colombo
Chem. Eur. J. 2015, 21, 13598 highlighted as Very Important Paper

New “clickable” polymeric coating for glycan microarrays C. Zilio; A. Bernardi; M. Salina; G. Tagliabue; M. Buscaglia; A. Palmioli; M. Chiari
Sensor actuat. B-Chem. 2015, 215 412-420