{"id":1130,"date":"2025-04-10T14:21:11","date_gmt":"2025-04-10T12:21:11","guid":{"rendered":"https:\/\/sites.unimi.it\/apisgroup\/?p=1130"},"modified":"2025-04-10T14:35:04","modified_gmt":"2025-04-10T12:35:04","slug":"application-of-modular-isoxazoline-beta22-aminoacid-based-peptidomimetics-as-chemical-modelsystems-for-studying-the-tau-misfolding","status":"publish","type":"post","link":"https:\/\/sites.unimi.it\/apisgroup\/2025\/04\/10\/application-of-modular-isoxazoline-beta22-aminoacid-based-peptidomimetics-as-chemical-modelsystems-for-studying-the-tau-misfolding\/","title":{"rendered":"Application of modular isoxazoline-beta2,2-aminoacid-based peptidomimetics as chemical model systems for studying the tau misfolding"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Tau is a microtubule-associated protein essential for regulating microtubule dynamics and axonal transport in neurons. In tauopathies, the transition of tau from a physiological to a pathological form remains unclear, though the hexapeptides PHF6 and PHF6* are key in triggering aggregation. These sequences are shielded by a beta-hairpin structure in the native state but expose hydrophobic residues during misfolding, promoting self-assembly. This study employs a non-natural beta2-amino acid to induce PHF6 and PHF6* into either extended or beta-hairpin conformations. The extended form triggers tau aggregation without additives, acting as a seed-competent monomer model system. Conversely, the beta-hairpin preserves tau in a soluble monomeric state. Additionally, a beta-hairpin mimic inspired by Hsp90 showed potential as a chaperone mimic and inhibitor of tau aggregation, offering insights into corrective folding and aggregation modulation in neuronal<br>environments.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/doi.org\/10.1016\/j.isci.2025.112272\">https:\/\/doi.org\/10.1016\/j.isci.2025.112272<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tau is a microtubule-associated protein essential for regulating microtubule dynamics and axonal transport in neurons. In tauopathies, the transition of tau from a physiological to a pathological form remains unclear, though the hexapeptides PHF6&#46;&#46;&#46;<\/p>\n","protected":false},"author":1,"featured_media":1132,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,5],"tags":[172,171,170],"class_list":["post-1130","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-application","category-peptidomimetics","tag-beta-hairpin","tag-misfolding","tag-tau-protein"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Application of modular isoxazoline-beta2,2-aminoacid-based peptidomimetics as chemical model systems for studying the tau misfolding - APIS group<\/title>\n<meta name=\"description\" content=\"This study employs a non-natural beta2-amino acid to induce PHF6 and PHF6* into either 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content=\"2025-04-10T12:35:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sites.unimi.it\/apisgroup\/wp-content\/uploads\/2025\/04\/screenshot-1744287159104.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"555\" \/>\n\t<meta property=\"og:image:height\" content=\"559\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"emanuela erba\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"emanuela erba\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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