The development of molecular carriers able to carry molecules directly into the cell is an area of intensive
\nresearch. Cationic nanoparticles are effective delivery systems for several classes of molecules, such as anticancer
\nagents, oligonucleotides and antibodies. Indeed, a cationic charge on the outer surface allows a
\nrapid cellular uptake together with the possibility of carrying negatively charged molecules. In this work, we
\nstudied the self-assembly of an ultra-short \u03b1\u03b1\u03b2-tripeptide containing an L-Arg\u2013L-Ala sequence and an unnatural
\nfluorine substituted \u03b22,3-diaryl-amino acid. The presence of the unnatural \u03b22,3-diaryl-amino acid
\nallowed us to obtain a protease stable sequence. Furthermore, an arginine guanidinium group triggered the
\nformation of spherical assemblies that were able to load small molecules and enter cells. These spherical
\narchitectures, thus, represent interesting candidates for the delivery of exogenous entities directly into cells.<\/p>\n","protected":false},"excerpt":{"rendered":"
The development of molecular carriers able to carry molecules directly into the cell is an area of intensive research. Cationic nanoparticles are effective delivery systems for several classes of molecules, such as anticancer agents,...<\/p>\n","protected":false},"author":1,"featured_media":382,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,7],"tags":[],"class_list":["post-381","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-application","category-amino-acid"],"yoast_head":"\n