{"id":913,"date":"2024-01-03T17:46:39","date_gmt":"2024-01-03T16:46:39","guid":{"rendered":"https:\/\/sites.unimi.it\/apisgroup\/?p=913"},"modified":"2024-01-03T17:46:44","modified_gmt":"2024-01-03T16:46:44","slug":"temporins-multifunctional-peptides-from-frog-skin","status":"publish","type":"post","link":"https:\/\/sites.unimi.it\/apisgroup\/2024\/01\/03\/temporins-multifunctional-peptides-from-frog-skin\/","title":{"rendered":"Temporins: Multifunctional Peptides from Frog Skin"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Temporins are short peptides secreted by frogs from all over the world. They exert antimicrobial activity, mainly against Gram-positive bacteria, including resistant pathogens; recent studies highlight other possible applications of these peptides as anticancer or antiviral agents. This<br>review is meant to describe the main features of temporins produced by different ranid genera. Due<br>to the abundance of published papers, we focus on the most widely investigated peptides. We report studies on their mechanism of action and three-dimensional structure in model systems mimicking bacterial membranes or in the presence of cells. The design and the antimicrobial activity of peptid  analogues is also described, with the aim of highlighting elements that are crucial to improve the bioactivity of peptides while reducing their toxicity. Finally, a short section is dedicated to the studies aimed at applying these peptides as drugs, to produce new antimicrobial materials or in other technological uses<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Int. J. Mol. Sci. 2023, 24, 5426.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/doi.org\/10.3390\/ijms24065426\">https:\/\/doi.org\/10.3390\/ijms24065426<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Temporins are short peptides secreted by frogs from all over the world. They exert antimicrobial activity, mainly against Gram-positive bacteria, including resistant pathogens; recent studies highlight other possible applications of these peptides as anticancer&#46;&#46;&#46;<\/p>\n","protected":false},"author":1,"featured_media":914,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[109,46],"tags":[111,110],"class_list":["post-913","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-peptides","category-review","tag-frog-skin","tag-temporins"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Temporins: Multifunctional Peptides from Frog Skin - APIS group<\/title>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Temporins: Multifunctional Peptides from Frog Skin - APIS group\" \/>\n<meta property=\"og:description\" content=\"Temporins are short peptides secreted by frogs from all over the world. They exert antimicrobial activity, mainly against Gram-positive bacteria, including resistant pathogens; recent studies highlight other possible applications of these peptides as anticancer&#046;&#046;&#046;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.unimi.it\/apisgroup\/2024\/01\/03\/temporins-multifunctional-peptides-from-frog-skin\/\" \/>\n<meta property=\"og:site_name\" content=\"APIS group\" \/>\n<meta property=\"article:published_time\" content=\"2024-01-03T16:46:39+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-01-03T16:46:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sites.unimi.it\/apisgroup\/wp-content\/uploads\/2024\/01\/ijms-24-05426-g003-550.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"356\" \/>\n\t<meta property=\"og:image:height\" content=\"550\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"emanuela erba\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"emanuela erba\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/2024\\\/01\\\/03\\\/temporins-multifunctional-peptides-from-frog-skin\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/2024\\\/01\\\/03\\\/temporins-multifunctional-peptides-from-frog-skin\\\/\"},\"author\":{\"name\":\"emanuela erba\",\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/#\\\/schema\\\/person\\\/983a9690b88e39642466bb60ddc30c84\"},\"headline\":\"Temporins: Multifunctional Peptides from Frog Skin\",\"datePublished\":\"2024-01-03T16:46:39+00:00\",\"dateModified\":\"2024-01-03T16:46:44+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/2024\\\/01\\\/03\\\/temporins-multifunctional-peptides-from-frog-skin\\\/\"},\"wordCount\":160,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/2024\\\/01\\\/03\\\/temporins-multifunctional-peptides-from-frog-skin\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/ijms-24-05426-g003-550.jpg\",\"keywords\":[\"Frog Skin\",\"Temporins\"],\"articleSection\":[\"peptides\",\"Review\"],\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/2024\\\/01\\\/03\\\/temporins-multifunctional-peptides-from-frog-skin\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/2024\\\/01\\\/03\\\/temporins-multifunctional-peptides-from-frog-skin\\\/\",\"url\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/2024\\\/01\\\/03\\\/temporins-multifunctional-peptides-from-frog-skin\\\/\",\"name\":\"Temporins: Multifunctional Peptides from Frog Skin - APIS group\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/2024\\\/01\\\/03\\\/temporins-multifunctional-peptides-from-frog-skin\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/2024\\\/01\\\/03\\\/temporins-multifunctional-peptides-from-frog-skin\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/ijms-24-05426-g003-550.jpg\",\"datePublished\":\"2024-01-03T16:46:39+00:00\",\"dateModified\":\"2024-01-03T16:46:44+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/2024\\\/01\\\/03\\\/temporins-multifunctional-peptides-from-frog-skin\\\/#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/2024\\\/01\\\/03\\\/temporins-multifunctional-peptides-from-frog-skin\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/2024\\\/01\\\/03\\\/temporins-multifunctional-peptides-from-frog-skin\\\/#primaryimage\",\"url\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/ijms-24-05426-g003-550.jpg\",\"contentUrl\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/ijms-24-05426-g003-550.jpg\",\"width\":356,\"height\":550},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/2024\\\/01\\\/03\\\/temporins-multifunctional-peptides-from-frog-skin\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Temporins: Multifunctional Peptides from Frog Skin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/#website\",\"url\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/\",\"name\":\"APIS group\",\"description\":\"Amino acids, Peptidomimetics, peptides, protein InteractionS group\",\"publisher\":{\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"it-IT\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/#organization\",\"name\":\"unimi.it\",\"url\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/wp-content\\\/uploads\\\/2015\\\/06\\\/logouniv.jpeg\",\"contentUrl\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/wp-content\\\/uploads\\\/2015\\\/06\\\/logouniv.jpeg\",\"width\":186,\"height\":64,\"caption\":\"unimi.it\"},\"image\":{\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/sites.unimi.it\\\/apisgroup\\\/#\\\/schema\\\/person\\\/983a9690b88e39642466bb60ddc30c84\",\"name\":\"emanuela erba\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/1e7cde6c268a8211405dc8ae2c27c5ce7bf21dccba0902783bd783ecdacca7ee?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/1e7cde6c268a8211405dc8ae2c27c5ce7bf21dccba0902783bd783ecdacca7ee?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/1e7cde6c268a8211405dc8ae2c27c5ce7bf21dccba0902783bd783ecdacca7ee?s=96&d=mm&r=g\",\"caption\":\"emanuela erba\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Temporins: Multifunctional Peptides from Frog Skin - APIS group","robots":{"index":"noindex","follow":"follow"},"og_locale":"it_IT","og_type":"article","og_title":"Temporins: Multifunctional Peptides from Frog Skin - APIS group","og_description":"Temporins are short peptides secreted by frogs from all over the world. They exert antimicrobial activity, mainly against Gram-positive bacteria, including resistant pathogens; recent studies highlight other possible applications of these peptides as anticancer&#46;&#46;&#46;","og_url":"https:\/\/sites.unimi.it\/apisgroup\/2024\/01\/03\/temporins-multifunctional-peptides-from-frog-skin\/","og_site_name":"APIS group","article_published_time":"2024-01-03T16:46:39+00:00","article_modified_time":"2024-01-03T16:46:44+00:00","og_image":[{"width":356,"height":550,"url":"https:\/\/sites.unimi.it\/apisgroup\/wp-content\/uploads\/2024\/01\/ijms-24-05426-g003-550.jpg","type":"image\/jpeg"}],"author":"emanuela erba","twitter_card":"summary_large_image","twitter_misc":{"Scritto da":"emanuela erba","Tempo di lettura stimato":"1 minuto"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/sites.unimi.it\/apisgroup\/2024\/01\/03\/temporins-multifunctional-peptides-from-frog-skin\/#article","isPartOf":{"@id":"https:\/\/sites.unimi.it\/apisgroup\/2024\/01\/03\/temporins-multifunctional-peptides-from-frog-skin\/"},"author":{"name":"emanuela erba","@id":"https:\/\/sites.unimi.it\/apisgroup\/#\/schema\/person\/983a9690b88e39642466bb60ddc30c84"},"headline":"Temporins: Multifunctional Peptides from Frog Skin","datePublished":"2024-01-03T16:46:39+00:00","dateModified":"2024-01-03T16:46:44+00:00","mainEntityOfPage":{"@id":"https:\/\/sites.unimi.it\/apisgroup\/2024\/01\/03\/temporins-multifunctional-peptides-from-frog-skin\/"},"wordCount":160,"commentCount":0,"publisher":{"@id":"https:\/\/sites.unimi.it\/apisgroup\/#organization"},"image":{"@id":"https:\/\/sites.unimi.it\/apisgroup\/2024\/01\/03\/temporins-multifunctional-peptides-from-frog-skin\/#primaryimage"},"thumbnailUrl":"https:\/\/sites.unimi.it\/apisgroup\/wp-content\/uploads\/2024\/01\/ijms-24-05426-g003-550.jpg","keywords":["Frog Skin","Temporins"],"articleSection":["peptides","Review"],"inLanguage":"it-IT","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/sites.unimi.it\/apisgroup\/2024\/01\/03\/temporins-multifunctional-peptides-from-frog-skin\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/sites.unimi.it\/apisgroup\/2024\/01\/03\/temporins-multifunctional-peptides-from-frog-skin\/","url":"https:\/\/sites.unimi.it\/apisgroup\/2024\/01\/03\/temporins-multifunctional-peptides-from-frog-skin\/","name":"Temporins: Multifunctional Peptides from Frog Skin - APIS group","isPartOf":{"@id":"https:\/\/sites.unimi.it\/apisgroup\/#website"},"primaryImageOfPage":{"@id":"https:\/\/sites.unimi.it\/apisgroup\/2024\/01\/03\/temporins-multifunctional-peptides-from-frog-skin\/#primaryimage"},"image":{"@id":"https:\/\/sites.unimi.it\/apisgroup\/2024\/01\/03\/temporins-multifunctional-peptides-from-frog-skin\/#primaryimage"},"thumbnailUrl":"https:\/\/sites.unimi.it\/apisgroup\/wp-content\/uploads\/2024\/01\/ijms-24-05426-g003-550.jpg","datePublished":"2024-01-03T16:46:39+00:00","dateModified":"2024-01-03T16:46:44+00:00","breadcrumb":{"@id":"https:\/\/sites.unimi.it\/apisgroup\/2024\/01\/03\/temporins-multifunctional-peptides-from-frog-skin\/#breadcrumb"},"inLanguage":"it-IT","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sites.unimi.it\/apisgroup\/2024\/01\/03\/temporins-multifunctional-peptides-from-frog-skin\/"]}]},{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/sites.unimi.it\/apisgroup\/2024\/01\/03\/temporins-multifunctional-peptides-from-frog-skin\/#primaryimage","url":"https:\/\/sites.unimi.it\/apisgroup\/wp-content\/uploads\/2024\/01\/ijms-24-05426-g003-550.jpg","contentUrl":"https:\/\/sites.unimi.it\/apisgroup\/wp-content\/uploads\/2024\/01\/ijms-24-05426-g003-550.jpg","width":356,"height":550},{"@type":"BreadcrumbList","@id":"https:\/\/sites.unimi.it\/apisgroup\/2024\/01\/03\/temporins-multifunctional-peptides-from-frog-skin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sites.unimi.it\/apisgroup\/"},{"@type":"ListItem","position":2,"name":"Temporins: Multifunctional Peptides from Frog Skin"}]},{"@type":"WebSite","@id":"https:\/\/sites.unimi.it\/apisgroup\/#website","url":"https:\/\/sites.unimi.it\/apisgroup\/","name":"APIS group","description":"Amino acids, Peptidomimetics, peptides, protein InteractionS group","publisher":{"@id":"https:\/\/sites.unimi.it\/apisgroup\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sites.unimi.it\/apisgroup\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"it-IT"},{"@type":"Organization","@id":"https:\/\/sites.unimi.it\/apisgroup\/#organization","name":"unimi.it","url":"https:\/\/sites.unimi.it\/apisgroup\/","logo":{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/sites.unimi.it\/apisgroup\/#\/schema\/logo\/image\/","url":"https:\/\/sites.unimi.it\/apisgroup\/wp-content\/uploads\/2015\/06\/logouniv.jpeg","contentUrl":"https:\/\/sites.unimi.it\/apisgroup\/wp-content\/uploads\/2015\/06\/logouniv.jpeg","width":186,"height":64,"caption":"unimi.it"},"image":{"@id":"https:\/\/sites.unimi.it\/apisgroup\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/sites.unimi.it\/apisgroup\/#\/schema\/person\/983a9690b88e39642466bb60ddc30c84","name":"emanuela erba","image":{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/secure.gravatar.com\/avatar\/1e7cde6c268a8211405dc8ae2c27c5ce7bf21dccba0902783bd783ecdacca7ee?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/1e7cde6c268a8211405dc8ae2c27c5ce7bf21dccba0902783bd783ecdacca7ee?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/1e7cde6c268a8211405dc8ae2c27c5ce7bf21dccba0902783bd783ecdacca7ee?s=96&d=mm&r=g","caption":"emanuela erba"}}]}},"_links":{"self":[{"href":"https:\/\/sites.unimi.it\/apisgroup\/wp-json\/wp\/v2\/posts\/913","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.unimi.it\/apisgroup\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.unimi.it\/apisgroup\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.unimi.it\/apisgroup\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.unimi.it\/apisgroup\/wp-json\/wp\/v2\/comments?post=913"}],"version-history":[{"count":1,"href":"https:\/\/sites.unimi.it\/apisgroup\/wp-json\/wp\/v2\/posts\/913\/revisions"}],"predecessor-version":[{"id":915,"href":"https:\/\/sites.unimi.it\/apisgroup\/wp-json\/wp\/v2\/posts\/913\/revisions\/915"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sites.unimi.it\/apisgroup\/wp-json\/wp\/v2\/media\/914"}],"wp:attachment":[{"href":"https:\/\/sites.unimi.it\/apisgroup\/wp-json\/wp\/v2\/media?parent=913"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.unimi.it\/apisgroup\/wp-json\/wp\/v2\/categories?post=913"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.unimi.it\/apisgroup\/wp-json\/wp\/v2\/tags?post=913"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}