2024

Bifunctional Photocatalysts Display Proximity-Enhanced Catalytic Activity in Metallaphotoredox C–O Coupling
L. Dolcini, A. Solida, D. Lavelli, A. Mauricio Hidalgo-Núñez, T. Gandini, M. Fornara, A. Colella, A. Bossi, M. Penconi, D. Fiorito, C. Gennari, A. Dal Corso, L. Pignataro
ACS Catal. 2024, 14, 18651–18659. View at Publisher

Achieving High Affinity for a Bacterial Lectin with Reversible Covalent Ligands
G. Antonini, A. Bernardi, E. Gillon, A. Dal Corso, M. Civera, L. Belvisi, A. Varrot, S. Mazzotta
J. Med. Chem. 2024, 67, 19546–19560. View at Publisher

Synthesis of Noncoded Amino Acids Bearing a Salicylaldehyde Tag for the Design of Reversible-Covalent Peptides
M. Mason, B. Nava, L. Belvisi, L. Pignataro, A. Dal Corso.
Eur. J. Org. Chem. 2024, 27, e202400229. View at Publisher (Open Access)

Amine-Carbamate Self-Immolative Spacers Counterintuitively Release 3° Alcohol at Much Faster Rates than 1° Alcohol Payloads
M. Mason, L. Bisbal Lopez, F. Bashiri, A. Herrero, A. Baron, R. Bucci, L. Pignataro, C. Gennari, A. Dal Corso.
ChemBioChem 2024, 25, e202400174. View at Publisher (Open Access)

2023

Ex vivo mass spectrometry-based biodistribution analysis of an antibody-Resiquimod conjugate bearing a protease-cleavable and acid-labile linker
L. Bisbal Lopez,  D. Ravazza,  M. Bocci, A. Zana, L. Principi, S. Dakhel Plaza, A. Galbiati, E. Gilardoni, J. Scheuermann, D. Neri, L. Pignataro, C. Gennari,
S. Cazzamalli, A. Dal Corso.
Front. Pharmacol. 2023, DOI: 10.3389/fphar.2023.1320524. View at Publisher (Open Access)

A Tight Contact: the Expanding Application of Salicylaldehydes in Lysine-targeting Covalent Drugs
M. Mason, L. Belvisi, L. Pignataro, A. Dal Corso
ChemBioChem 2023, DOI: 10.1002/cbic.202300743. View at Publisher (Open Access)

Visible Light-Promoted β-Functionalization of Carbonyl Compounds in the Presence of Organic Dyes
L. Dolcini, T. Gandini, R. Castiglioni, A. Bossi, M. Penconi, A. Dal Corso, C. Gennari, L. Pignataro
J. Org. Chem. 2023, 88, 14283–14291. View at Publisher

Design, Synthesis and Catalytic Activity of (Cyclopentadienone)iron Complexes Containing a Stereogenic Plane and a Stereogenic Axis
G. M. Fusi, T. Gandini, S. Gazzola, T. Grell, V. Colombo, L. Pignataro, U. Piarulli
Chem. Eur. J. 2023, DOI: 10.1002/chem.202302533. View at Publisher (Open Access)

RGD Cyclopeptide Equipped with a Lysine-Engaging Salicylaldehyde Showing Enhanced Integrin Affinity and Cell Detachment Potency
G. Sacco, D. Arosio, M. Paolillo, A. Gloger, J. Scheuermann, L. Pignataro, L. Belvisi, A. Dal Corso, C. Gennari
Chem. Eur. J. 2023, 29, e202203768. View at Publisher (Open Access)

2022

Metallaphotoredox C−O and C−N Cross-Coupling Using Donor-Acceptor Cyanoarene Photocatalysts
T. Gandini, L. Dolcini, L. Di Leo, M. Fornara, A. Bossi, M. Penconi, A. Dal Corso, C. Gennari, L. Pignataro
ChemCatChem 2022, 14, e202200990. View at Publisher

Advanced Pyrrolidine-Carbamate Self-Immolative Spacer with Tertiary Amine Handle
Induces Superfast Cyclative Drug Release
A. Dal Corso, M. Frigoli, M. Prevosti, M. Mason, R. Bucci, L. Belvisi, L. Pignataro, C. Gennari
ChemMedChem 2022, 17, e202200279. View at Publisher (Open Access)

Regiodivergent Reductive Opening of Epoxides by Catalytic Hydrogenation Promoted by a (Cyclopentadienone)iron Complex
L. Tadiello, T. Gandini, B. M. Stadler, S. Tin, H. Jiao, J. G. de Vries, L. Pignataro, C. Gennari. 
ACS Catalysis 2022, 12, 235-246. View at Publisher

2021

A Trifunctional Self-Immolative Spacer Enables Drug Release with Two Non-Sequential Enzymatic Cleavages
A. Dal Corso, S. Arosio, N. Arrighetti, P. Perego, L. Belvisi, L. Pignataro, C. Gennari. 
Chem. Commun. 2021, 57, 7778-7781. View at Publisher

Functionalized 2‐Hydroxybenzaldehyde‐PEG Modules as Portable Tags for the Engagement of Protein Lysine ε‐Amino Groups
G. Sacco, S. Stammwitz, L. Belvisi, L. Pignataro, A. Dal Corso, C. Gennari. 
Eur. J. Org. Chem. 2021, 2021, 1763-1767. View at Publisher

2020

Multimeric Presentation of RGD Peptidomimetics Enhances Integrin Binding and Tumor Cell Uptake
A. Pina, M. Kadri, D. Arosio, A. Dal Corso, J. Coll, C. Gennari, D. Boturyn. 
Chem. Eur. J. 2020, 26, 7492-7496. View at Publisher

Recent Catalytic Applications of (Cyclopentadienone)iron Complexes
L. Pignataro, C. Gennari
Eur. J. Org. Chem. 2020, 2020, 3192-3205. View at Publisher

Fast Cyclization of a Proline‐Derived Self‐Immolative Spacer Improves the Efficacy of Carbamate Prodrugs
A. Dal Corso, V. Borlandelli, C. Corno, P. Perego, L. Belvisi, L. Pignataro, C. Gennari
Angew. Chem. Int. Ed. 2020, 59, 4176-4181. View at Publisher

2019

A dimeric bicyclic RGD ligand displays enhanced integrin binding affinity and strong biological effects on U-373 MG glioblastoma cells - G. Sacco, A. Dal Corso, D. Arosio, L. Belvisi, M. Paolillo, L. Pignataro, C. Gennari
Org. Biomol. Chem. 2019, 17, 8913-8917. View at Publisher

Innovative linker strategies for tumor‐targeted drug conjugates - A. Dal Corso, L. Pignataro, L. Belvisi, C. Gennari
Chem. Eur. J. 2019, 25, 14740-14757. View at Publisher

Hydrogen-Borrowing Amination of Secondary Alcohols Promoted by a (Cyclopentadienone)iron Complex - X. Bai, F. Aiolfi, M. Cettolin, U. Piarulli, A. Dal Corso, L. Pignataro, C. Gennari
Synthesis. 2019, 51, 3545-3555. View at Publisher

β-Glucuronidase triggers extracellular MMAE release from an integrin-targeted conjugate - P. López Rivas, C. Müller, C. Breunig, T. Hechler, A. Pahl, D. Arosio, L. Belvisi, L. Pignataro, A. Dal Corso, C. Gennari
Org. Biomol. Chem. 2019, 17, 4705-4710. View at Publisher

Rational Design of Antiangiogenic Helical Oligopeptides Targeting the Vascular Endothelial Growth Factor Receptors - S. Zanella, G. Bocchinfuso, M. De Zotti, D. Arosio, F. Marino, S. Raniolo, L. Pignataro, G. Sacco, A. Palleschi, A. S. Siano, U. Piarulli, L. Belvisi, F. Formaggio, C. Gennari, L. Stella.
Front. Chem. 2019, 7, 170. View at Publisher

Synthesis and Biological Evaluation of RGD and isoDGR–Monomethyl Auristatin Conjugates Targeting Integrin αVβ3 - A. Raposo Moreira Dias, L. Bodero, A. Martins, D. Arosio, S. Gazzola, L. Belvisi, L. Pignataro, C. Steinkühler, A. Dal Corso, C. Gennari, U. Piarulli.
ChemMedChem 2019, 14, 938-942. View at Publisher (Open Access)

Chiral (cyclopentadienone)iron complexes with a stereogenic plane as pre-catalysts for the asymmetric hydrogenation of polar double bonds - X. Bai, M. Cettolin, G. Mazzoccanti, M. Pierini, U. Piarulli, V. Colombo, A. Dal Corso, L. Pignataro, C. Gennari.
Tetrahedron 2019, 75, 1415-1424. View at Publisher

Neutrophil Elastase Promotes Linker Cleavage and Paclitaxel Release from an Integrin‐Targeted Conjugate - A. Raposo Moreira Dias, A. Pina, A. Dean, H.‐G. Lerchen, M. Caruso, F. Gasparri, I. Fraietta, S. Troiani, D. Arosio, L. Belvisi, L. Pignataro, A. Dal Corso, C. Gennari.
Chem. Eur. J. 2019, 25, 1696-1700. View at Publisher (Open Access)

2018

Synthesis and Biological Evaluation of Paclitaxel Conjugates Involving Linkers Cleavable by Lysosomal Enzymes and αVβ3‐Integrin Ligands for Tumor Targeting - P. López Rivas, I. Ranđelović, A. Raposo Moreira Dias, A. Pina, D. Arosio, J. Tóvári, G. Mező, A. Dal Corso, L. Pignataro, C. Gennari.
Eur. J. Org. Chem. 2018, 2902-2909. View at Publisher (Open Access)

Improving C=N Bond Reductions with (Cyclopentadienone)iron Complexes: Scope and Limitations - M. Cettolin, X. Bai, D. Lübken, M. Gatti, S. Vailati Facchini, U. Piarulli, L. Pignataro, C. Gennari.
Eur. J. Org. Chem. 2019, 647-654. View at Publisher

Efficient Synthesis of Amines by Iron-Catalyzed C=N Transfer Hydrogenation and C=O Reductive Amination - S. Vailati Facchini, M. Cettolin, X. Bai, G. Casamassima, L. Pignataro, C. Gennari, U. Piarulli.
Adv. Synth. Catal. 2018, 360, 1054-1059. View at Publisher

Synthesis and Biological Evaluation of RGD and isoDGR Peptidomimetic-α-Amanitin Conjugates for Tumor-Targeting - L. Bodero, P. López Rivas, B. Korsak, T. Hechler, A. Pahl, C. Müller, D. Arosio, L. Pignataro, C. Gennari, U. Piarulli.
Beilstein J. Org. Chem. 2018, 14, 407–415. View at Publisher (Open Access)

2017

Multivalency Increases the Binding Strength of RGD Peptidomimetic-Paclitaxel Conjugates to Integrin αVβ3 - 
A. Raposo Moreira Dias, A. Pina, A. Dal Corso, D. Arosio, L. Belvisi, L. Pignataro, M. Caruso, C. Gennari.
Chem. Eur. J. 2017, 23, 14410-14415. View at Publisher (Open Access)

Investigating the interaction of cyclic RGD peptidomimetics with αVβ6 integrin by biochemical and molecular docking studies - 
M. Civera, D. Arosio, F. Bonato, L. Manzoni, L. Pignataro, S. Zanella, C. Gennari, U. Piarulli, L. Belvisi.
Cancers 2017, 9, 128. View at Publisher (Open Access)

Use of the Trost Ligand in Ruthenium-Catalyzed Asymmetric Hydrogenation of Ketones - M. Cettolin, P. Puylaert, L. Pignataro, S. Hinze, C. Gennari, J. G. de Vries.ChemCatChem 2017, 9, 3125-3130. View at Publisher

Targeting Integrin αVβ3 with Theranostic RGD-Camptothecin Conjugates Bearing a Disulfide Linker: Biological Evaluation Reveals a Complex Scenario - A. Pina, A. Dal Corso, M. Caruso, L. Belvisi, D. Arosio, S. Zanella, F. Gasparri, C. Albanese, U. Cucchi, I. Fraietta, A. Marsiglio, L. Pignataro, D. Donati, C. Gennari.
ChemistrySelect 2017, 2, 4759-4766. View at Publisher

Tumor Targeting with an isoDGR-Drug Conjugate - S. Zanella, S. Angerani, A. Pina, P. López Rivas, C. Giannini, S. Panzeri, D. Arosio, M. Caruso, F. Gasparri, I. Fraietta, C. Albanese, A. Marsiglio, L. Pignataro, L. Belvisi, U. Piarulli, C. Gennari.
Chem. Eur. J. 2017, 23, 7910-7914. View at Publisher (Open Access)

Synthesis of [bis(hexamethylene)cyclopentadienone]iron tricarbonyl and its application to catalytic reductions of C=O bonds - S. Vailati Facchini, J.-M. Neudörfl, L. Pignataro, M. Cettolin, C. Gennari, A. Berkessel, U. Piarulli.
ChemCatChem 2017, 9, 1461-1468. View at Publisher

Insights into the binding of cyclic RGD peptidomimetics to α5β1 integrin by live cell NMR and computational studies - I. Guzzetti, M. Civera, F. Vasile, D. Arosio, C. Tringali, U. Piarulli, C. Gennari, L. Pignataro, L. Belvisi, D. Potenza.
ChemistryOpen 2017, 6, 128-136. View at Publisher (Open Access)

2016

Riding the wave of monodentate ligand revival: from the A/B concept to non-covalent interactions - L. Pignataro, C. Gennari.
Chem. Rec. 2016, 16, 2544 - 2560. View at Publisher

Expanding the catalytic scope of (cyclopentadienone)iron complexes to the hydrogenation of activated esters to alcohols - P. Gajewski, A. Gonzalez-de-Castro, M. Renom-Carrasco, U. Piarulli, C. Gennari, J. G. de Vries, L. Lefort, L. Pignataro.
ChemCatChem 2016, 8, 3431-3435. View at Publisher

A Mixed Ligand Approach for the Asymmetric Hydrogenation of 2-Substituted Pyridinium Salts - M. Renom-Carrasco, P. Gajewski, L. Pignataro, J. G. de Vries, U. Piarulli, C. Gennari, L. Lefort.
Adv. Synth. Catal. 2016, 358, 2589-2593. View at Publisher

Asymmetric Hydrogenation of 3-Substituted Pyridinium Salts - M. Renom-Carrasco, P. Gajewski, L. Pignataro, J. G. de Vries, U. Piarulli, C. Gennari, L. Lefort.
Chem. Eur. J. 2016, 22, 9528-9532. View at Publisher

Asymmetric Transfer Hydrogenation of Ketones with modified Grubbs Metathesis Catalysts: On the Way to a Tandem Process - M. Renom-Carrasco, P. Gajewski, L. Pignataro, J. G. de Vries, U. Piarulli, C. Gennari, L. Lefort.
Adv. Synth. Catal. 2016, 358, 515-519. View at Publisher

αVβ3 Integrin-Targeted Peptide/Peptidomimetic-Drug Conjugates: In-Depth Analysis of the Linker Technology -
A. Dal Corso, L. Pignataro, L. Belvisi, C. Gennari.
Curr. Top. Med. Chem. 2016, 16, 314-329. View at Publisher (Open Access)

2015

Synthesis of a 4-Vinyltetrahydrocarbazole by Palladium-Catalyzed Asymmetric Allylic Alkylation of Indole-Containing Allylic Carbonates - L. Pignataro, D. Fiorito, V. Vece, R. Ferraccioli, C. Gennari.
Eur. J. Org. Chem. 2015, 18, 6669-6678. View at Publisher

Synthesis, characterization and biological evaluation of a dual action ligand targeting αVβ3 integrin and VEGF receptors - S. Zanella, M. Mingozzi, A. Dal Corso, R. Fanelli, D. Arosio, M. Cosentino, L. Schembri, F. Marino, M. De Zotti, F. Formaggio, L. Pignataro, L. Belvisi, U. Piarulli, C. Gennari.
ChemistryOpen 2015, 4, 633-641. View at Publisher (Open Access)

Synthesis of (R)-BINOL-Derived (Cyclopentadienone)iron Complexes and Their Application in the Catalytic Asymmetric Hydrogenation of Ketones - P. Gajewski, M. Renom-Carrasco, S. Vailati Facchini, L. Pignataro, L. Lefort, J. G. de Vries, R. Ferraccioli, U. Piarulli, C. Gennari.
Eur. J. Org. Chem. 2015, 18, 5526-5536. View at Publisher

Assisted Tandem Catalysis: Metathesis Followed by Asymmetric Hydrogenation from a Single Ruthenium Source - M. Renom-Carrasco, P. Gajewski, L. Pignataro, J. G. de Vries, U. Piarulli, C. Gennari, L. Lefort.
Adv. Synth. Catal. 2015, 357, 2223-2228. View at Publisher

Synthesis and Biological Evaluation of RGD Peptidomimetic-Paclitaxel Conjugates bearing Lysosomally Cleavable Linkers - A. Dal Corso, M. Caruso, L. Belvisi, D. Arosio, U. Piarulli, C. Albanese, F. Gasparri, A. Marsiglio, F. Sola, S. Troiani, B. Valsasina, L. Pignataro, D. Donati, C. Gennari.
Chem. Eur. J. 2015, 21, 6921-6929. View at Publisher

Cyclic isoDGR and RGD Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds are Integrin Antagonists - S. Panzeri, S. Zanella, D. Arosio, L. Vahdati, A. Dal Corso, L. Pignataro, M. Paolillo, S. Schinelli, L. Belvisi, C. Gennari, U. Piarulli.
Chem. Eur. J. 2015, 21, 6265-6271. View at Publisher

Chiral (Cyclopentadienone)iron Complexes for the Catalytic Asymmetric Hydrogenation of Ketones - P. Gajewski, M. Renom-Carrasco, S. Vailati Facchini, L. Pignataro, L. Lefort, J. G. de Vries, R. Ferraccioli, A. Forni, U. Piarulli, C. Gennari.
Eur. J. Org. Chem. 2015, 18, 1887-1893. View at Publisher

2014

Enantioselective synthesis of 1-vinyltetrahydroisoquinolines through palladium-catalysed intramolecular allylic amidation with chiral PhthalaPhos ligands - L. Pignataro, E. Marelli, C. Gennari, R. Ferraccioli.
Tetrahedron: Asymmetry 2014, 25, 844-850. View at Publisher

Synthesis and biological evaluation of dual action cyclo-RGD/SMAC mimetic conjugates targeting αVβ3 /αVβ5 integrins and IAP proteins - M. Mingozzi, L. Manzoni, D. Arosio, A. Dal Corso, M. Manzotti, F. Innamorati, L. Pignataro, D. Lecis, D. Delia, P. Seneci, C. Gennari.
Org. Biomol. Chem., 2014, 12, 3288-3302. View at Publisher