Participants
Updated 20/6/2022
| A. De Simone | University of Naples |
| Y. Ivarsson | Uppsala Universitet |
| E. Papaleo | University of Copenhagen |
| G. Lattanzi | University of Trento |
| R. Potestio | University of Trento |
| P. Faccioli | University of Trento |
| S. Gianni | University of Roma La Sapienza |
| G. Tartaglia | IIT & University of Roma La Sapienza |
| F. Chiti | University of Florence |
| M. Manno | CNR Palermo |
| R. Covino | Frankfurt Institute for Advanced Studies |
| S. Carra | University of Modena and Reggio Emilia |
| R. Battistutta | University of Padua |
| M. Fuxreiter | University of Padua |
| M. G. Ortore | Polytechnical University of Marche |
| F. Malagrinò | University of Naples |
| M. Vendruscolo | University of Cambridge |
| E. Paci | University of Bologna |
| G. Colombo | University of Pavia |
| B. Bolognesi | IBEC, Barcelona |
| A. Kumawat | University of Milano |
| E. Scalone | University of Milano |
| F. Ballabio | University of Milano |
| T. Bellini | University of Milano |
| G. Ruocco | University of Roma La Sapienza |
| A. Relini | University of Genova |
| F. Piazza | University of Firenze |
| S. Cocco | ENS Paris |
| D. Ghamari | University of Trento |
| K. Degn | University of Copenhagen |
| L. Beltrame | University of Copenhagen |
| C. Visentin | University of Milano |
| L. Broggini | University of Milano |
| E. Marchi | University of Milano |
| A. Toto | University of Roma La Sapienza |
| C. Nardella | University of Roma La Sapienza |
| L. Pagano | University of Roma La Sapienza |
| V. Pennachietti | University of Roma La Sapienza |
| A. Diop | University of Roma La Sapienza |
| C. Paternoster | University of Trento |
| L. Petrolli | University of Trento |
| G. Giachin | University of Padua |
| M. Monti | IIT |
| J. Rupert | IIT & University of Roma La Sapienza |
| E. Zaccco | IIT |
| R. Menichetti | University of Trento |
| T. Tarenzi | University of Trento |
| R. Capelli | University of Milano |
| M. Cagiada | University of Copenhagen |
The program
Monday 5th
14.15-14.30 Welcome
14.30-15.00 Maria Grazia Ortore (Politechnical University of Marche), Exploring the failure and the success of interfering with amyloid aggregation.
15.15-15.45 Fabrizio Chiti (University of Firenze), Aminosterols against neurodegenerative diseases.
coffee break
16.15-16.45 Elena Papaleo (University of Copenhagen), Structure-based studies of disordered motifs and protein variants in cancer.
17.00-18.30 short talks: Kristine Degn (University of Copenhagen), In Silico Examination of Local and Long-range effects of cancer mutations in p53. Emanuele Scalone (University of Milano) Multi-eGO: an in-silico lens to look into protein aggregation kinetics at atomic resolution, Thomas Tarenzi (University of Trento), From atomistic simulations to variable-resolution modelling of multidomain proteins. Leonardo Salicari (University of Padova), Folding kinetics of an entangled protein. Riccardo Capelli (University of Milano), Waiter, there’s some ice in my water! Matteo Cagiada (University of Copenhagen), Discover functional sites in proteins using evolution and structural information.
Tuesday 6th
9.00-9.30 Alfonso De Simone (University of Napoli), Catching elusive amyloidogenic intermediates using NMR.
9.45-10.15 Gianluca Lattanzi (University of Trento), Molecular Dynamics simulations: experimental data speak louder than models.
10.30-11.00 Roberto Battistutta (University of Padova), Conformational variability in the SARS-CoV-2 main protease Mpro.
coffee break
11.30-12.00 Giorgio Colombo (University of Pavia), How Post-Translational Modifications of a Chaperone Codes for a Switch in Function in the folding machinery: An Atomistic View.
12.15-12.45 Stefano Gianni (University of Roma1), Allostery frustrates the experimentalists.
lunch break
14.00-14.30 Tommaso Bellini (University of Milano), Synthetic evolution of DNA oligomers.
14.45-15.15 Mauro Manno (CNR Palermo), Molecular camouflage by extracellular vesicles: a spy in the house of life.
15.30-16.00 Pietro Faccioli (University of Trento), Progress in the pharmacological inactivation of proteins by targeting folding intermediates. .
coffee break
16.30-17.00 Amit Kumawat (University of Milano), Rekindle Therapeutic Strategies for Long QT Syndrome from Gain of Function (IKr) Mutations in hERG Channels.
17.15-18.45 short talks: Francesca Malagrinò (University of Napoli), Folding of a PDZ tandem repeat – a cryptic physiological role for a misfolded intermediate. Ludovica Beltrame (University of Copenhagen), MAVISp: Multi-layered Assessment of VarIants by Structure for proteins. Federico Ballabio (University of Milano), Accelerating SAXS intensities calculation of in-silico models. Lorenzo Petrolli (University of Trento), A multiscale assessment of DNA double strand breaks. Edoardo Marchi (University of Milano), Loop extrusion in the dynamics of chromosome folding. Gabriele Giachin (University of Padova), Integrative structural biology approaches to unveil the link between mitochondrial Complex I and an acyl Co-A dehydrogenase from the fatty acid beta-oxidation pathway.
Wednesday 7th
9.00-9.30 Giangaetano Tartaglia (IIT & University of Roma1), Phase separation and long non-coding RNA rule the world!.
9.45-10.15 Annalisa Relini (University of Genova), Effect of cholesterol-tuned membrane fluidity on nanoparticle-membrane interaction
10.30-11.00 Monika Fuxreiter (University of Padova), Proteins as cellular matter.
coffee break
11.30-12.00 Roberto Covino (MPI Frankfürt), Investigating mechanisms of biomolecular self‐organization by integrating physics‐based simulations and AI.
12.15-12.45 Benedetta Bolognesi (IBEC Barcelona), Deep mutagenesis to understand amyloid nucleation.
lunch break
14.00-14.30 Serena Carra (University of Modena and Reggio Emilia), Small heat shock proteins act on the α-synuclein lipid-induced aggregation process through multiple mechanisms..
14.45-15.15 Francesco Piazza, (University of Firenze), The physics of boundary conditions in reaction-diffusion problems.
15.30-16.00 Edoardo Milanetti (University of Roma), The shape complementarity evaluation at the interfaces of biomolecule complexes: a novel method based on Zernike polynomials.
coffee break
16.30-18.15 short talks: Cristina Visentin (University of Milano), Beta-2 microglobulin amyloid aggregation and multiple myeloma progression: a toxic relationship. Danial Ghamari (University of Trento), Transition path sampling with quantum computers. Luca Broggini (University of Milano), Nanobodies as novel potential drugs to target cardiac light chain amyloidosis. Mattia Miotto (University of Roma1) Towards the prediction of the human interactome: fast assessment of protein-protein binding propensity. Michele Monti and Jakob Rupert (IIT & University of Roma1) The effect of RNA on alpha synuclein aggregation. Elsa Zacco (IIT) Exploring early events in protein aggregation with RNA aptamers. Livia Pagano (University of Roma) The kinetics of folding of a PDZ tandem repeat.
Thursday 8th
9.00-9.30 Michele Vendruscolo (University of Cambridge), Kinetics-Based Drug Discovery for Neurodegenerative Diseases.
9.45-10.15 Ylva Ivarsson (Uppsala University), Proteome-wide discovery of motif-mediated interactions in health and disease.
10.30-11.00 Emanuele Paci (University of Bologna), Hydrogen-deuterium exchange and mass spectrometry: coarse data and structure inference
coffee break
11.30-12.00 Roberto Menichetti (University of Trento), Coarse-grained models and filters: investigating biological matter via information-theoretic approaches.
12.15-12.45 short talks: Solange Marie Flatt (EPFL), ABC Transporters are billion-year old Maxwell Demons. Daniele Santorelli (University of Roma), Unveiling the mechanism of cooperative folding in a PDZ multidomain system.