Personal information:
First name(s): Daniele
Surname(s): Cartelli
Address: via Rovigo 21, 20093 Cololgno Monzese (MI), Italy
Telephone: +393334920793
E-mail:
daniele.cartelli@unimi.it
Nationality: Italian
Date of Birth: 1982/07/18
Gender: Male
Education and Training:
2004
Bachelor in Biological Sciences (100/110) at the Università degli Studi di Milano (Milano, Italy),
with a thesis entitled : “ Immunocytochemical analysis of the cholinergic innervations in the cerebral
cortex of rodents” , under the supervision of Dr. A. Amadeo
2006 Degree in Biology applied to Biomedical research (107/110) at the Università degli Studi di
Milano (Milano, Italy), with a thesis entitled: “Study on the involvement of microtubule dynamic in
neurotoxin model of Parkinson’s disease”, under the supervision of Dr. G. Cappelletti
2010 PhD in Cellular and Molecular Biology at the Università degli Studi di Milano (Milano, Italy),
with a thesis entitled: “Microtubule dysfunctions in experimental models of Parkinson’s disease”,
under the supervision of Dr. G. Cappelletti
Work Experience:
2006-2010 PhD student in Cellular and Molecular Biology
May 2010-May 2011 Technician at CIMaINa (Multidisciplinar Center of Nanostructured Materials and
Interfaces) for the use of the Laser Scanning Confocal Microscopy
May 2011-onwards Post doc position at the Università degli Studi di Milano (Milano, Italy), with a
research project entitled: “Microtubule dysfunction: is it the primary or an accessory culprit in MPTP
model of Parkinson’s disease?”, under the supervision of Dr. G. Cappelletti
Personal Skill and Competences:
Mother Tongue(s): Italian
Other language(s): English
Social skills and competences:
Team work: I have worked in various types of teams from research teams to
rugby team.
Technical skills and competences:
Competent with basic biochemical approach (SDS-PAGE and Western
Blotting), immunofluorescence and immunohistochemistry, cell culture,
confocal microscopy and live cell imaging. Experience with synuclein and
tubulin purification and in vitro polymerization assay.
Experience with animal care, brain lysates, perfusion and sectioning.
Computer skills and competences:
Competent with most Microsoft programs and experience with Adobe and
some Statistical programs.
Driving:
I hold a driving licence for both car and bike.
Pubblications:
Inhibitors of tubulin polymerization: synthesis and biological evaluation of hybrids of vindoline,
anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III.
Passarella D, Giardini A, Peretto B, Fontana G, Sacchetti A, Silvani A, Ronchi C, Cappelletti G, Cartelli D,
Borlak J, Danieli B.
Bioorg Med Chem. 2008 Jun 1;16(11):6269-85.
Semisynthesis of new D-seco-C-nor-taxane derivatives containing a polyfunctionalized furanosyl or
cyclopentenyl or cyclopentyl C-ring.
Gelmi ML, Nava D, Leone S, Pellegrino S, Baldelli E, Zunino F, Cappelletti G, Cartelli D, Fontana G.
J Org Chem. 2008 Nov 21;73(22):8893-900.
Pleiotropic effects of spastin on neurite growth depending on expression levels.
Riano E, Martignoni M, Mancuso G, Cartelli D, Crippa F, Toldo I, Siciliano G, Di Bella D, Taroni F, Bassi
MT, Cappelletti G, Rugarli EI.
J Neurochem. 2009 Mar;108(5):1277-88.
Synthesis and biological evaluation of epothilone A dimeric compounds.
Passarella D, Comi D, Cappelletti G, Cartelli D, Gertsch J, Quesada AR, Borlak J, Altmann KH.
Bioorg Med Chem. 2009 Nov;17(21):7435-40.
In silico design of tubulin-targeted antimitotic peptides
Pieraccini S, Saladino G, Cappelletti G, Cartelli D, Francescato P, Speranza G, Manitto P, Sironi M.
Nature Chemistry 2009 Nov; 1(8):642-648.
Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates.
Passarella D, Peretto B, Blasco y Yepes R, Cappelletti G, Cartelli D, Ronchi C, Snaith J, Fontana G, Danieli
B, Borlak J.
Eur J Med Chem. 2010 Jan;45(1):219-26.
Microtubule dysfunction precedes transport impairment and mitochondrial damage in
MPP+-induced neurodegeneration.
Cartelli D, Ronchi C, Maggioni MG, Rodighiero S, Giavini E, Cappelletti G.
J. Neurochem. 2010 Oct; 115: 247-258.
Tubulin-guided dynamic combinatorial library of thiocolchicine-podophyllotoxin conjugates
Cappelletti G, Cartelli D, Peretto B, Ventura M, Riccioli M, Colombo F, Snaith JS, Borrelli S, Passarella D.
TETRAHEDRON 2011 Sep; 38:3754-3757.
Mesenchymal Stromal Cells Primed with Paclitaxel Provide a New Approach for Cancer Therapy
Pessina A, Bonomi A, Coccè V, Invernici G, Navone S, Cavicchini L, Sisto F, Ferrari M, Viganò L, Locatelli
A, Ciusani E, Cappelletti G, Cartelli D, Arnaldo C, Parati E, Marfia G, Pallini R, Falchetti ML, Alessandri
G.
PLoS One 2011;6(12):e28321.
Microtubule Destabilization Is Shared by Genetic and Idiopathic Parkinson’s Disease Patient
Fibroblasts
Cartelli D, Goldwurm S, Casagrande F, Pezzoli G, Cappelletti G.
PLos One 2012; 7(5):e37467
Biofilm formation on nanostructured titanium oxide surfaces and a micro/nanofabrication-based
preventive strategy using colloidal lithography
Singh AJ, Vyas V, Salve TS, Cartelli D, Dellasega D, Podesta A, Milani P, Gade WN.
Biofabrication 2012; 4:025001
Molecular dynamics and tubulin polymerization kinetics study on 1,14-heterofused axanes: evidence
of stabilization of the tubulin head-to-tail dimer–dimer interaction
Contini A, Cappelletti G, Cartelli D, Fontana G, Gelmi ML.
Mol. BioSystems 2012; 8:3254-3261
Investigation of in vitro cytotoxicity of the redox state of ionic iron in neuroblastoma cells
Singh AV, Vyas V, Maontani E, Cartelli D, Parazzoli D, Oldani A, Zeri G, Orioli E, Gemmati D, Zamboni P.
Journal of Neurosciences in Rural Practice 2012; 3:301-310
Neuritin 1 promotes neuronal migration
Zito A*, Cartelli D*, Cappelletti G, Cariboni A, Andrews W, Parnavelas J, Poletti A, Galbiati M.
Brain Structure and Function, DOI 10.1007/s00429-012-0487-1
Centaurin-α2 Interacts with β-Tubulin and Stabilizes Microtubules
Zuccotti P*, Cartelli D*, Stroppi M*, Pandini V, Venturin M, Aliverti A, Battaglioli E, Cappelletti G, Riva
P.
PLoS One 2012; 7(12):e52867
Preparation of fluorescent tubulin dimers
Riva E, Mattarella M, Borrelli S, Christodoulou MS, Cartelli D, Main M, Faulkner S, Sykes D, Cappelletti
G, Snaith JS, Passarella D.
ChemPlusChem 2013; 78:222-226.
Microtubule alterations occur early in experimental parkinsonism and the microtubule stabilizer
Epothilone D is neuroprotective
Cartelli D, Casagrande F, Busceti CL, Bucci D, Molinaro G, Traficante A, Passarella D, Giavini G, Pezzoli
G, Battaglia G, Cappelletti G.
Scientific Reports 3:1837
9-Fluorenone-2-Carboxylic Acid as a Scaffold for Tubulin Interacting Compounds
Calogero F, Borrelli S, Speciale G, Christodoulou MS, Cartelli D, Ballinari D, Sola F, Albanese C,
Ciavolella A, Passarella D, Cappelletti G, Pieraccini S, Sironi M.
ChemPlusChem 2013; 78:663-669.
*equal contribution
anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III.
Passarella D, Giardini A, Peretto B, Fontana G, Sacchetti A, Silvani A, Ronchi C, Cappelletti G, Cartelli D,
Borlak J, Danieli B.
Bioorg Med Chem. 2008 Jun 1;16(11):6269-85.
Semisynthesis of new D-seco-C-nor-taxane derivatives containing a polyfunctionalized furanosyl or
cyclopentenyl or cyclopentyl C-ring.
Gelmi ML, Nava D, Leone S, Pellegrino S, Baldelli E, Zunino F, Cappelletti G, Cartelli D, Fontana G.
J Org Chem. 2008 Nov 21;73(22):8893-900.
Pleiotropic effects of spastin on neurite growth depending on expression levels.
Riano E, Martignoni M, Mancuso G, Cartelli D, Crippa F, Toldo I, Siciliano G, Di Bella D, Taroni F, Bassi
MT, Cappelletti G, Rugarli EI.
J Neurochem. 2009 Mar;108(5):1277-88.
Synthesis and biological evaluation of epothilone A dimeric compounds.
Passarella D, Comi D, Cappelletti G, Cartelli D, Gertsch J, Quesada AR, Borlak J, Altmann KH.
Bioorg Med Chem. 2009 Nov;17(21):7435-40.
In silico design of tubulin-targeted antimitotic peptides
Pieraccini S, Saladino G, Cappelletti G, Cartelli D, Francescato P, Speranza G, Manitto P, Sironi M.
Nature Chemistry 2009 Nov; 1(8):642-648.
Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates.
Passarella D, Peretto B, Blasco y Yepes R, Cappelletti G, Cartelli D, Ronchi C, Snaith J, Fontana G, Danieli
B, Borlak J.
Eur J Med Chem. 2010 Jan;45(1):219-26.
Microtubule dysfunction precedes transport impairment and mitochondrial damage in
MPP+-induced neurodegeneration.
Cartelli D, Ronchi C, Maggioni MG, Rodighiero S, Giavini E, Cappelletti G.
J. Neurochem. 2010 Oct; 115: 247-258.
Tubulin-guided dynamic combinatorial library of thiocolchicine-podophyllotoxin conjugates
Cappelletti G, Cartelli D, Peretto B, Ventura M, Riccioli M, Colombo F, Snaith JS, Borrelli S, Passarella D.
TETRAHEDRON 2011 Sep; 38:3754-3757.
Mesenchymal Stromal Cells Primed with Paclitaxel Provide a New Approach for Cancer Therapy
Pessina A, Bonomi A, Coccè V, Invernici G, Navone S, Cavicchini L, Sisto F, Ferrari M, Viganò L, Locatelli
A, Ciusani E, Cappelletti G, Cartelli D, Arnaldo C, Parati E, Marfia G, Pallini R, Falchetti ML, Alessandri
G.
PLoS One 2011;6(12):e28321.
Microtubule Destabilization Is Shared by Genetic and Idiopathic Parkinson’s Disease Patient
Fibroblasts
Cartelli D, Goldwurm S, Casagrande F, Pezzoli G, Cappelletti G.
PLos One 2012; 7(5):e37467
Biofilm formation on nanostructured titanium oxide surfaces and a micro/nanofabrication-based
preventive strategy using colloidal lithography
Singh AJ, Vyas V, Salve TS, Cartelli D, Dellasega D, Podesta A, Milani P, Gade WN.
Biofabrication 2012; 4:025001
Molecular dynamics and tubulin polymerization kinetics study on 1,14-heterofused axanes: evidence
of stabilization of the tubulin head-to-tail dimer–dimer interaction
Contini A, Cappelletti G, Cartelli D, Fontana G, Gelmi ML.
Mol. BioSystems 2012; 8:3254-3261
Investigation of in vitro cytotoxicity of the redox state of ionic iron in neuroblastoma cells
Singh AV, Vyas V, Maontani E, Cartelli D, Parazzoli D, Oldani A, Zeri G, Orioli E, Gemmati D, Zamboni P.
Journal of Neurosciences in Rural Practice 2012; 3:301-310
Neuritin 1 promotes neuronal migration
Zito A*, Cartelli D*, Cappelletti G, Cariboni A, Andrews W, Parnavelas J, Poletti A, Galbiati M.
Brain Structure and Function, DOI 10.1007/s00429-012-0487-1
Centaurin-α2 Interacts with β-Tubulin and Stabilizes Microtubules
Zuccotti P*, Cartelli D*, Stroppi M*, Pandini V, Venturin M, Aliverti A, Battaglioli E, Cappelletti G, Riva
P.
PLoS One 2012; 7(12):e52867
Preparation of fluorescent tubulin dimers
Riva E, Mattarella M, Borrelli S, Christodoulou MS, Cartelli D, Main M, Faulkner S, Sykes D, Cappelletti
G, Snaith JS, Passarella D.
ChemPlusChem 2013; 78:222-226.
Microtubule alterations occur early in experimental parkinsonism and the microtubule stabilizer
Epothilone D is neuroprotective
Cartelli D, Casagrande F, Busceti CL, Bucci D, Molinaro G, Traficante A, Passarella D, Giavini G, Pezzoli
G, Battaglia G, Cappelletti G.
Scientific Reports 3:1837
9-Fluorenone-2-Carboxylic Acid as a Scaffold for Tubulin Interacting Compounds
Calogero F, Borrelli S, Speciale G, Christodoulou MS, Cartelli D, Ballinari D, Sola F, Albanese C,
Ciavolella A, Passarella D, Cappelletti G, Pieraccini S, Sironi M.
ChemPlusChem 2013; 78:663-669.
*equal contribution
Congress:
8th International Conference AD/PD, Salzburg, Austria, March 14-18, 2007
Neuronal microtubule dynamics as a novel target for the parkinsonism producing
neurotoxin MPTP.
Ronchi C, Cartelli D, Maggioni MG, Rodighiero S, Giavini E, Cappelletti G.
3rd Meeting on the Molecular Mechanism of Neurodegeneration, Milan, Italy, May 19-21, 2007
Linking neuronal degeneration to microtubule dynamics by the parkinsonism toxin
MPP+-mediated microtubule destabilization.
Cartelli D, Ronchi C, Maggioni MG, Rodighiero S, Giavini E, Cappelletti G.
Gruppo Embriologico Italiano 53° Congresso, Giardini-Naxos, Italia, 6-9 Giugno, 2007
Ruolo di neuritina nel differenziamento neuronale indotto da NGF.
Cappelletti G, Galbiati R, Ronchi C, Onesto E, Cartelli D, Giavini E, Poletti A.
ELSO Proceedings, Dresden, Germany, September 1-4, 2007
Enrichment in stable microtubules reveals dysfunction of microtubule dynamics occurring in
Parkinson’s disease models
Cartelli D, Ronchi C, Maggioni MG, Molinaro G, Battaglia G, Giavini E, Cappelletti G.
XIII National Congress of the Italian society for Neuroscience, Verona, Italy, September 27-30, 2007
Neuritin (cpg15) enhances the differentiating effect of NGF on neuronal PC12 cells
Galbiati M, Cappelletti G, Ronchi C, Cartelli D, Onesto E, Poletti A.
ELSO Proocedings, Nice France, August 30-September 2, 2008
Role of Neuritin (cpg15) on the NGF induced differentiation of neuronal PC12 cells
Galbiati M, Cappelletti G, Onesto E, Ronchi C, Cartelli D, Rusmini P, Zito A, Poletti A.
FISV, 10th Annual Congress, Riva del Garda, Italy, September 24-27, 2008
Effect of different isoforms of cpg15 (neuritin) on differentiating PC12 cells
Galbiati M, Cappelletti G, Cartelli D, Onesto E, Zito A, Poletti A.
II Workshop COST, Action Inhibitors of angiogenesis: design, synthesis and biological exploitation,
Favignana, October, 2008
Insight into microtubule dynamics: from purified protein to cell
Cappelletti G and Cartelli D.
4th Meeting on the Molecular Mechanism of Neurodegeneration, Milan, Italy, May 8-10, 2009
Is Microtubule imbalance an early event in MPTP-induced neurodegeneration?
Cartelli D, Molinaro G, Battaglia G, Busceti CL, Giavini E, Cappelletti G.
European Human Genetics Conference, ACV, Vienna, Austria, May 23-26, 2009
Searching for Centaurin-2 interacting proteins: evidence of interaction with tubulin-β
Stroppi M, Crippa M, Venturin M, Cartelli D, Cappelletti G, Battaglioli E, Riva P.
FISV, 11st Annual Congress, Riva del Garda, Italy, September 23-25, 2009
Centaurin-α2 interacts with tubulin-β through microtubules’ anchoring
Stroppi M, Crippa M, Cartelli D, Cappelletti G, Venturin M, Battaglioli E, Riva P.
XIII National Congress of the Italian society for Neuroscience, Milan, Italy, September 29- October 1, 2009
Microtubule dynamics imbalance leads to axonal transport impairment in MPP+-treated PC12 cells
Cartelli D, Toscano A, Giavini E, Cappelletti G.
XIII National Congress of the Italian society for Neuroscience, Milan, Italy, September 29- October 1, 2009
Protein tyrosine nitration: a beneficial or detrimental cue during neuronal differentiation
Toscano A, Cartelli D, Ronchi C, Tedeschi G, Cappelletti G.
XIII National Congress of the Italian society for Neuroscience, Milan, Italy, September 29- October 1, 2009
Neuritin: a regulatory protein of neuronal migration
Galbiati M, Cappelletti G, Zito A, Cartelli D, Cariboni A, Poletti A.
EMBO Conference series, Microtubules: structure, regulation and functions, Heidelberg, Germany, June 2-5,
2010
Microtubule dysfunction in experimental model of Parkinson’s disease
Cartelli D, Battaglia G, Cappelletti G.
5th Meeting on the Molecular Mechanism of Neurodegeneration, Milan, Italy, May 13-15, 2011
Parkin absence impacts microtubule stability and axonal transport in knockout mice
Cartelli D, Sassone J, Amadeo A, Ciammola A, Cappelletti G.
5th Meeting on the Molecular Mechanism of Neurodegeneration, Milan, Italy, May 13-15, 2011
Microtubule stability is precociously affected in a mouse model of Parkinson’s disease
Cartelli D, Casagrande F, Battaglia G, Busceti C, Molinaro G, Cappelletti G.
The 3rd EMBO meeting, Vienna, Austria, September 10-13, 2011
-Synuclein nucleates short microtubules
Cartelli D., Aliverti A., Barbiroli A., Bonomi F., Cappelletti G.
EMBO Conference 2nd in a series, Microtubules: structure, regulation and functions, Heidelberg, Germany,
May 23-26, 2012
-Synuclein promotes microtubule nucleation
Cartelli D., Gritti M., Aliverti A, Barbiroli A., Cappelletti G.
EMBO Conference 2nd in a series, Microtubules: structure, regulation and functions, Heidelberg, Germany,
May 23-26, 2012
Parkin absence impacts microtubule stability and axonal transport in silenced neuronal cells and
knockout mice
Casagrande F.*, Cartelli D.*, Hanusova K., Amadeo A., Sassone J., and Cappelletti G.
The 11th International Conference on Alzheimer’s and Parkinson’s Diseases, Florence, Italy, March 6-10,
2013
Microtubule alterations occur early in esperimental parkinsonism and the microtubule stabilizer
Epothilone D is neuroprotective
Cartelli D., Casagrande F., Battaglia G., Busceti C., Molinaro G., and Cappelletti G.
Neuronal microtubule dynamics as a novel target for the parkinsonism producing
neurotoxin MPTP.
Ronchi C, Cartelli D, Maggioni MG, Rodighiero S, Giavini E, Cappelletti G.
3rd Meeting on the Molecular Mechanism of Neurodegeneration, Milan, Italy, May 19-21, 2007
Linking neuronal degeneration to microtubule dynamics by the parkinsonism toxin
MPP+-mediated microtubule destabilization.
Cartelli D, Ronchi C, Maggioni MG, Rodighiero S, Giavini E, Cappelletti G.
Gruppo Embriologico Italiano 53° Congresso, Giardini-Naxos, Italia, 6-9 Giugno, 2007
Ruolo di neuritina nel differenziamento neuronale indotto da NGF.
Cappelletti G, Galbiati R, Ronchi C, Onesto E, Cartelli D, Giavini E, Poletti A.
ELSO Proceedings, Dresden, Germany, September 1-4, 2007
Enrichment in stable microtubules reveals dysfunction of microtubule dynamics occurring in
Parkinson’s disease models
Cartelli D, Ronchi C, Maggioni MG, Molinaro G, Battaglia G, Giavini E, Cappelletti G.
XIII National Congress of the Italian society for Neuroscience, Verona, Italy, September 27-30, 2007
Neuritin (cpg15) enhances the differentiating effect of NGF on neuronal PC12 cells
Galbiati M, Cappelletti G, Ronchi C, Cartelli D, Onesto E, Poletti A.
ELSO Proocedings, Nice France, August 30-September 2, 2008
Role of Neuritin (cpg15) on the NGF induced differentiation of neuronal PC12 cells
Galbiati M, Cappelletti G, Onesto E, Ronchi C, Cartelli D, Rusmini P, Zito A, Poletti A.
FISV, 10th Annual Congress, Riva del Garda, Italy, September 24-27, 2008
Effect of different isoforms of cpg15 (neuritin) on differentiating PC12 cells
Galbiati M, Cappelletti G, Cartelli D, Onesto E, Zito A, Poletti A.
II Workshop COST, Action Inhibitors of angiogenesis: design, synthesis and biological exploitation,
Favignana, October, 2008
Insight into microtubule dynamics: from purified protein to cell
Cappelletti G and Cartelli D.
4th Meeting on the Molecular Mechanism of Neurodegeneration, Milan, Italy, May 8-10, 2009
Is Microtubule imbalance an early event in MPTP-induced neurodegeneration?
Cartelli D, Molinaro G, Battaglia G, Busceti CL, Giavini E, Cappelletti G.
European Human Genetics Conference, ACV, Vienna, Austria, May 23-26, 2009
Searching for Centaurin-2 interacting proteins: evidence of interaction with tubulin-β
Stroppi M, Crippa M, Venturin M, Cartelli D, Cappelletti G, Battaglioli E, Riva P.
FISV, 11st Annual Congress, Riva del Garda, Italy, September 23-25, 2009
Centaurin-α2 interacts with tubulin-β through microtubules’ anchoring
Stroppi M, Crippa M, Cartelli D, Cappelletti G, Venturin M, Battaglioli E, Riva P.
XIII National Congress of the Italian society for Neuroscience, Milan, Italy, September 29- October 1, 2009
Microtubule dynamics imbalance leads to axonal transport impairment in MPP+-treated PC12 cells
Cartelli D, Toscano A, Giavini E, Cappelletti G.
XIII National Congress of the Italian society for Neuroscience, Milan, Italy, September 29- October 1, 2009
Protein tyrosine nitration: a beneficial or detrimental cue during neuronal differentiation
Toscano A, Cartelli D, Ronchi C, Tedeschi G, Cappelletti G.
XIII National Congress of the Italian society for Neuroscience, Milan, Italy, September 29- October 1, 2009
Neuritin: a regulatory protein of neuronal migration
Galbiati M, Cappelletti G, Zito A, Cartelli D, Cariboni A, Poletti A.
EMBO Conference series, Microtubules: structure, regulation and functions, Heidelberg, Germany, June 2-5,
2010
Microtubule dysfunction in experimental model of Parkinson’s disease
Cartelli D, Battaglia G, Cappelletti G.
5th Meeting on the Molecular Mechanism of Neurodegeneration, Milan, Italy, May 13-15, 2011
Parkin absence impacts microtubule stability and axonal transport in knockout mice
Cartelli D, Sassone J, Amadeo A, Ciammola A, Cappelletti G.
5th Meeting on the Molecular Mechanism of Neurodegeneration, Milan, Italy, May 13-15, 2011
Microtubule stability is precociously affected in a mouse model of Parkinson’s disease
Cartelli D, Casagrande F, Battaglia G, Busceti C, Molinaro G, Cappelletti G.
The 3rd EMBO meeting, Vienna, Austria, September 10-13, 2011
-Synuclein nucleates short microtubules
Cartelli D., Aliverti A., Barbiroli A., Bonomi F., Cappelletti G.
EMBO Conference 2nd in a series, Microtubules: structure, regulation and functions, Heidelberg, Germany,
May 23-26, 2012
-Synuclein promotes microtubule nucleation
Cartelli D., Gritti M., Aliverti A, Barbiroli A., Cappelletti G.
EMBO Conference 2nd in a series, Microtubules: structure, regulation and functions, Heidelberg, Germany,
May 23-26, 2012
Parkin absence impacts microtubule stability and axonal transport in silenced neuronal cells and
knockout mice
Casagrande F.*, Cartelli D.*, Hanusova K., Amadeo A., Sassone J., and Cappelletti G.
The 11th International Conference on Alzheimer’s and Parkinson’s Diseases, Florence, Italy, March 6-10,
2013
Microtubule alterations occur early in esperimental parkinsonism and the microtubule stabilizer
Epothilone D is neuroprotective
Cartelli D., Casagrande F., Battaglia G., Busceti C., Molinaro G., and Cappelletti G.
Courses:
Molecular and Cellular Neurobiology, Milan, Italy, June 2006
4° conference on “real time” PCR. Technological approaches in the post-genomic era: beyond “Real Time”
PCR. Milan, Italy, September 2006
New frontiers in biology: stem cells, scientific research and clinical applications, Milan, Italy, February
2007
In vivo cellular migration and immunofluorescence, Milan, Italy, March 2007
Time-lapse micrscopy & live cell imaging course, Anacapri, Italy, May 2007
Mechanisms of mitosis and cell division, Milan, Italy, September 2007
Workshop on Mechanism and Dynamics of the cytoskeleton: microtubules, Milan, Italy, May 2009
Cellular and Molecular Responses to Stress, Milan, Italy, June 2009
XIV School on Pure and Applied Biophysics on Molecular Mechanisms of Neurodegeneration, Venice, Italy,
January 2010
2008. Fellowship Lifelong Learning Programme Erasmus Placement: 3 months stage at the Chretien laboratory
(Rennes, France), under the supervision of Isabelle Arnal to learn the VEDIC (Video Enhanced Differential
Interference Contrast) microscopy technique.
2012. 2 weeks in the laboratory of Dr Arnal (Grenoble Institut des Neurosciences, Grenoble, France) to perform
VEDIC microscopy experiments on the effects of -Synuclein on microtubule dynamics
4° conference on “real time” PCR. Technological approaches in the post-genomic era: beyond “Real Time”
PCR. Milan, Italy, September 2006
New frontiers in biology: stem cells, scientific research and clinical applications, Milan, Italy, February
2007
In vivo cellular migration and immunofluorescence, Milan, Italy, March 2007
Time-lapse micrscopy & live cell imaging course, Anacapri, Italy, May 2007
Mechanisms of mitosis and cell division, Milan, Italy, September 2007
Workshop on Mechanism and Dynamics of the cytoskeleton: microtubules, Milan, Italy, May 2009
Cellular and Molecular Responses to Stress, Milan, Italy, June 2009
XIV School on Pure and Applied Biophysics on Molecular Mechanisms of Neurodegeneration, Venice, Italy,
January 2010
2008. Fellowship Lifelong Learning Programme Erasmus Placement: 3 months stage at the Chretien laboratory
(Rennes, France), under the supervision of Isabelle Arnal to learn the VEDIC (Video Enhanced Differential
Interference Contrast) microscopy technique.
2012. 2 weeks in the laboratory of Dr Arnal (Grenoble Institut des Neurosciences, Grenoble, France) to perform
VEDIC microscopy experiments on the effects of -Synuclein on microtubule dynamics
Teachings Experiences:
Course of “Histology”, in the faculty of osteopathy, for the academic year 2007-2008
Laboratory of “Comparative Anatomy”, degree in Natural Sciences, academic year 2009-2010, 2010-
2011 and 2011-2012
Seminar: “Live cell imaging: principles and applications in the study of cellular dynamics”, part of the
course on “survey instruments for the study of cells and molecules” for the PhD students of the school of
Morphological and Physiological Sciences, in the years 2009 and 2010
Co-tutor of many experimental thesis:
Rossi Federica, degree in Natural Sciences, Academic Year 2006-2007: “Neuronal cell:
university and school in the didactics experimentation”
Rota Paola, degree in Natural Sciences, Academic Year 2006-2007: “Nitric Oxide as
mediator in the neuronal differentiation process”
Scorza Stefano, bachelor in Natural Sciences, Academic Year 2007-2008: “Nitric Oxide:
positive modulator of neuronal differentiation”
Trevisan Simone, bachelor in Biological Sciences, Academic Year 2007-2008:
“Characterization of the biological activity of anti-tubulin peptides”
Toscano Arianna, degree in Biology applied to Biomedical research, Academic Year 2007-
2008: “Nitric Oxide and protein nitration: which role in neuronal differentiation?”
Gritti Marta, bachelor in Biological Sciences, Academic Year 2009-2010: “Molecular
mechanisms involved in the MPP+-induced neurodegeneration: synergic action between
mitochondrial damage and microtubular dysfunction”
Urzì Alice, bachelor in Biological Sciences, Academic Year 2009-2010: “From
differentiation to neurodegeneration: a possible role of the -synuclein in the regulation of
microtubule polymerization dynamics”
Canuti Andrea, degree in Biology applied to Biomedical research, Academic Year 2009-
2010: “ Analyses of the microtubular cytoskeleton in parkin knockout mice”
Falcioni Viviana, bachelor in Natural Sciences, Academic Year 2009-2010: “Nitric Oxide,
protein nitration and neuronal differentiation: the role of the inhibition of the guanylate
cyclase”
Fumagalli Laura, bachelor in Biological Sciences, Academic Year 2009-2010: “-
synuclein effects on neuronal differentiation and microtubule stability”
Segreto Alberto, degree in Biology applied to Biomedical research, Academic Year 2009-
2010: “-synuclein: characterization of the interaction with tubulin in vitro and
differentiated neuronal cells”
Lucano Ottavia, bachelor in Biological Sciences, Academic Year 2010-2011: “-
synuclein role during in vitro microtubule nucleation”
Limongi Laura, bachelor in Natural Sciences, Academic Year 2010-2011: “Parkin role in
the mitochondrial transport in differentiated neuronal cells”
Calcaterra Valerio, bachelor in Natural Sciences, Academic Year 2010-2011: “Parkin role
in the microtubule dynamics in differentiated neuronal cells”
Gritti Marta, degree in Molecular Biology of the Cell, Academic Year 2011-2012: “
Characterization of the interaction between -Synuclein and microtubules” )
Laboratory of “Comparative Anatomy”, degree in Natural Sciences, academic year 2009-2010, 2010-
2011 and 2011-2012
Seminar: “Live cell imaging: principles and applications in the study of cellular dynamics”, part of the
course on “survey instruments for the study of cells and molecules” for the PhD students of the school of
Morphological and Physiological Sciences, in the years 2009 and 2010
Co-tutor of many experimental thesis:
Rossi Federica, degree in Natural Sciences, Academic Year 2006-2007: “Neuronal cell:
university and school in the didactics experimentation”
Rota Paola, degree in Natural Sciences, Academic Year 2006-2007: “Nitric Oxide as
mediator in the neuronal differentiation process”
Scorza Stefano, bachelor in Natural Sciences, Academic Year 2007-2008: “Nitric Oxide:
positive modulator of neuronal differentiation”
Trevisan Simone, bachelor in Biological Sciences, Academic Year 2007-2008:
“Characterization of the biological activity of anti-tubulin peptides”
Toscano Arianna, degree in Biology applied to Biomedical research, Academic Year 2007-
2008: “Nitric Oxide and protein nitration: which role in neuronal differentiation?”
Gritti Marta, bachelor in Biological Sciences, Academic Year 2009-2010: “Molecular
mechanisms involved in the MPP+-induced neurodegeneration: synergic action between
mitochondrial damage and microtubular dysfunction”
Urzì Alice, bachelor in Biological Sciences, Academic Year 2009-2010: “From
differentiation to neurodegeneration: a possible role of the -synuclein in the regulation of
microtubule polymerization dynamics”
Canuti Andrea, degree in Biology applied to Biomedical research, Academic Year 2009-
2010: “ Analyses of the microtubular cytoskeleton in parkin knockout mice”
Falcioni Viviana, bachelor in Natural Sciences, Academic Year 2009-2010: “Nitric Oxide,
protein nitration and neuronal differentiation: the role of the inhibition of the guanylate
cyclase”
Fumagalli Laura, bachelor in Biological Sciences, Academic Year 2009-2010: “-
synuclein effects on neuronal differentiation and microtubule stability”
Segreto Alberto, degree in Biology applied to Biomedical research, Academic Year 2009-
2010: “-synuclein: characterization of the interaction with tubulin in vitro and
differentiated neuronal cells”
Lucano Ottavia, bachelor in Biological Sciences, Academic Year 2010-2011: “-
synuclein role during in vitro microtubule nucleation”
Limongi Laura, bachelor in Natural Sciences, Academic Year 2010-2011: “Parkin role in
the mitochondrial transport in differentiated neuronal cells”
Calcaterra Valerio, bachelor in Natural Sciences, Academic Year 2010-2011: “Parkin role
in the microtubule dynamics in differentiated neuronal cells”
Gritti Marta, degree in Molecular Biology of the Cell, Academic Year 2011-2012: “
Characterization of the interaction between -Synuclein and microtubules” )
