1995
G. Cappelletti, M. Camatini, E. Brambilla and R. Maci. 1991. N-Methyl-4-Phenyl-1,2,3,6-tetrahydropyridine
(MPTP) induces cytoskeletal alterations on mouse fibroblasts. Neurosci. Lett., 129: 149-152.
G. Cappelletti and R. Maci. 1993. Actin Filaments Disassembly: A Novel Step in The Genesis of Paraquat
Toxicity? Bull. Environ. Contam. Toxicol., 50: 717-723.
G. Cappelletti, C. Incani and R. Maci. 1994. Paraquat induces irreversible actin cytoskeleton disruption in
cultured human lung cells". Cell Biol. Toxicol., 10: 255-263.
G. Cappelletti, C. Incani and R. Maci. 1995. Involvement of tubulin in MPP+ neurotoxicity on NGF-
differentiated PC12 cells. Cell Biol. Int., 19: 687-693.
2001
G. Cappelletti, B. Pedrotti, M.G. Maggioni and R. Maci. 2001. Microtubule assembly is directly affected by
MPP+ in vitro”. Cell Biol. Int., 25: 981-984.
2004
2003
G. Cappelletti, M.G. Maggioni, G. Tedeschi and R. Maci. 2003. Protein tyrosine nitration is triggered by
nerve growth factor during neuronal differentiation of PC12 cells. Exp. Cell Res., 288: 9-20.
G. Cappelletti, G. Tedeschi, M.G. Maggioni, A. Negri, S. Nonnis and R. Maci. 2004. The nitration of tau
protein in neuron-like PC12 cells. FEBS Lett., 562: 35-39.
2005
G. Cappelletti, T. Surrey and R. Maci. 2005. The parkinsonism producing neurotoxin MPP+ affects microtubule
dynamics acting as a destabilising factor”. FEBS Lett., 579: 4781-6.
G. Tedeschi, G. Cappelletti, A. Negri, L. Pagliato, M.G. Maggioni. R. Maci and S. Ronchi. 2005. Characterization of
nitroproteome in neuron-like PC12 cells differentiated with NGF: identification of two nitrated sites in alpha-
tubulin”. Proteomics, 5: 2422-32.
2006
G. Cappelletti, M.G. Maggioni, C. Ronchi, R. Maci and G. Tedeschi. 2006. Protein tyrosine nitration is associated
with cold- and drug-resistant microtubules in neuronal-like PC12 cells. Neurosci. Lett., 401: 159-164.
2007
G. Cappelletti, M. Galbiati, C. Ronchi, M.G. Maggioni, E. Onesto and A. Poletti. 2007. Neuritin (cpg15) enhances
the differentiating effect of NGF on neuronal PC12 cells. J. Neurosci. Res., 85: 2702-13.
F. Di Renzo, G. Cappelletti, M. Broccia, E. Giavini and E. Menegola. 2007. Boric acid inhibits histone
deacetylases: a suggested mechanism to explain boric acid –related teratogenicity. Toxicol. Appl. Pharmacol.,
220(2): 178-185.
Tedeschi, G. Cappelletti, S. Nonnis, F. Taverna, A. Negri, C. Ronchi and S. Ronchi. 2007. Tyrosine nitration is a
novel post-translational modification occurring on the neural intermediate filament protein peripherin.
Neurochem. Res., 32: 433-41.
2008
S. Nonnis, G. Cappelletti, F. Taverna, C. Ronchi, S. Ronchi, A. Negri, E. Grassi and G. Tedeschi. 2008. TAU is
endogenously nitrated in mouse brain. Identification of tyrosine residues modified in vivo by NO. Neurochem.
Res. 33(3): 518-525.
E. Perrino, G. Cappelletti, V. Tazzari, E. Giavini, P. Del Soldato and A. Sparatore. 2008. New sulfurated derivatives
of valproic acid with enhanced histone deacetylase inhibitory activity”. Bioorg. Med. Chem. Lett. 18(6): 1893-7.
D. Passarella, A. Giardini, B. Peretto, G. Fontana, A. Sacchetti, A. Silvani, C. Ronchi, G. Cappelletti, D. Cartelli, J.
Borlak and B. Danieli. 2008. Inhibitors of tubulin polymerization: Synthesis and biological evaluation of hybrids of
vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III. Bioorg. Med.
Chem. 16(11) 6269-85.
F. Di Renzo, G. Cappelletti, M.Broccia, E. Giavini and E. Menegola. 2008. The inhibition of embryonic histone
deacetylases as the possible mechanism accounting for axial skeletal malformations induced by Sodium
Salicylate. Toxicol Sci. 104 (2) 397-404.
M.L. Gelmi, D. Nava, S. Leone, S. Pellegrino, E. Balzelli, F. Zumino, G. Cappelletti, D.Cartelli and G. Fontana 2008.
Semisynthesis of new D-seco-C-nor-taxane derivatives containing a polyfunctionalized furanosyl or cyclopentenyl
or cyclopentyl C-ring. J. Org. Chem. 73 (22) 8893-8900.
2009
V. Appierto, P. Tiberio, E. Cavadini, P. Casalini, G. Cappelletti, F. Formelli. 2009. Antimitotic effect of the retinoid
4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth-inhibitory
activity. Mol. Cancer Ther. 8(12) 3360-3368.
D. Passerella, D. Comi, G. Cappelletti, D. Cartelli, J. Gertsch, A.R. Quesada, J. Borlak, KH Altmann. 2009.
Synthesis and biological evaluation of epotilone A dimeric compound. Bioorg. Med. Chem.17 (21) 7435-40.
S. Pieraccini, G. Saladino, G. Cappelletti, D. Cartelli, P. Francescato, G. Speranza, P. Manitto, M-M. Sironi. 2009
In silico design of tubulin-targeted antimitotic peptides. Nature Chemistry 1(8), 642-648.
G.A. Pinna, G. Murineddu, C. Murruzzo, V. Zuco, G. Cappelletti, R. Artali, G. Cignarella, L. Solano, S. Villa. 2009.
Synthesis, modelling, and antimitotic properties of tricyclic systems characterised by a 2-(5-Phenyl-1 H-pyrrol-
3-yl)-1,3,4-oxadiazole moiety. ChemMedChem 4(6) 998-1009.
E. Riano, M. Martignoni, G. Mancuso, D. Cartelli, F. Crippa, I. Toldo, G. Siciliano, D. Di Bella, F. Taroni, M.T.
Bassi, G. Cappelletti, E.I. Rugarli. 2009. Pleiotropic effects of spastin on neurite growth depending on
expression levels. J. Neurochem. 108 (5) 1277-1288
2010
D. Cartelli, C. Ronchi, M.G. Maggioni, S. Rodighiero, E. Giavini, G. Cappelletti. 2010. Microtubule dysfunction
precedes transport impairment and mitochondria damage in MPP+-induced neurodegeneration. J. Neurochem. 115
(1) 247-258
V. Tazzari, G. Cappelletti, M. Casagrande, E. Perrino, L. Renzi, P. Del Soldato, A. Sparatore. 2010. New
aryldithiolethione derivatives as potent histone deacetylase. Bioorg. Med. Chem. 18 (12) 4187-4194
D. Passarella, B. Peretto, R. Blasco y Yepes, G. Cappelletti, D. Cartelli, C. Ronchi, J. Snaith, G. Fontana, B. Danieli,
J. Borlak. 2010. Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates. Eur J
Med Chem. 45 (1) 219-26.
2011
A. Pessina, A. Bonomi, V. Coccè, G. Invernici, S. Navone, L. Cavicchini, F. Sisto, M. Ferrari, L. Viganò, A.
Locatelli, E. Ciusani, G. Cappelletti, D. Cartelli, A. Caruso, E. Parati, G. Marfia, R. Pallini, ML Falchetti, G.
Alessandri. 2011. Mesenchymal stromal cells primed with Paclitaxel provide a new approach for cancer therapy.
PLos ONE 6 (12): e28321.
G. Cappelletti, D. Cartelli, B. Peretto, M. Ventura, M. Riccioli, F. Colombo, J.S. Snaith, S. Borrelli, D. Passerella.
2011. Tubulin-guided dynamic combinatorial library of thiocochicine-podophyllotoxin conjugates. Tetrahedron
67 (38) 7354-7357.
2012
P. Zuccotti, D. Cartelli, M. Stroppi, V. Pandini, M. Venturin, A. Aliverti, E. Battaglioli, Cappelletti G, P. Riva. 2012.
Centaurin-α₂ interacts with β-tubulin and stabilizes microtubules. PLoS ONE 7 (12): e52867.
A. Contini, G. Cappelletti, D. Cartelli, G. Fontana, M.L. Gelmi. 2012. Molecular dynamics and tubulin polymerization
kinetics study on 1,14-heterofused taxanes: evidences of stabilization of the tubulin head-to-tail dimmer-dimer
interaction. Molecular BioSystems 8 (12) 3254-3261.
D. Cartelli, S. Goldwurm, F. Casagrande, G. Pezzoli, G. Cappelletti. 2012. Microtubule destabilization is shared by
genetic and idiopathic Parkinson’s disease patient fibroblasts. PLoS ONE 7 (5): e37467.
2017
Cartelli D, Aliverti A, Barbiroli A, Santambrogio C, Ragg EM, Casagrande FV, Cantele F, Beltramone S,
Marangon J, De Gregorio C, Pandini V, Emanuele M, Chieregatti E, Pieraccini S, Holmqvist S, Bubacco L,
Roybon L, Pezzoli G, Grandori R, Arnal I, Cappelletti G. Sci Rep. 2016 Sep 15;6:33289. doi: 10.1038/srep33289.
α-Synuclein is a Novel Microtubule Dynamase
Piermarini E, Cartelli D, Pastore A, Tozzi G, Compagnucci C, Giorda E, D'Amico J, Petrini S, Bertini E,
Cappelletti G, Piemonte F. Hum Mol Genet. 2016 Aug 11. pii: ddw260. doi: 10.1093/hmg/ddw260.
Frataxin silencing alters microtubule stability in motor neurons: implications for Friedreich's ataxia.
Marangon J, Christodoulou MS, Casagrande FV, Tiana G, Dalla Via L, Aliverti A, Passarella D, Cappelletti G,
Ricagno S. Biochem Biophys Res Commun. 2016 Sep 7. pii: S0006-291X(16)31472-3.
doi:10.1016/j.bbrc.2016.09.022.
Tools for the rational design of bivalent microtubule-targeting drugs
Cappelletti G, Cartelli D, Christodoulou MS, Passarella D.
Curr Pharm Des. 2017 Feb 23;5:784 - 808. doi: 10.2174/1381612822666161214150544.
Microtubule-directed therapeutic strategy for neurodegenerative disorders: starting from the basis and
looking on the emergences.
2016
Cartelli D & Cappelletti G
Mol Neurobiol 2016 Oct. doi:10.1007/s12035-016-0188-5.
Microtubule Destabilization Paves the Way to Parkinson’s Disease.
1999
1998
1996
1994
1993
1991
1989
2015
2014
G. Cappelletti, M.G. Maggioni, M.D. Candia Carnevali, F. Bonasoro and R. Maci. 1996. Dynamic changes in the state of
actin polymerization in human alveolar cells exposed to the oxidant agent Paraquat. Eur. J. Cell Biol., 71: 293-302.
G. Cappelletti, M.G. Maggioni and R. Maci. 1998. Apoptosis in human lung epithelial cells: triggering by
Paraquat and modulation by antioxidants. Cell Biol. Int., 22: 671-678.
T. Huff, G. Cappelletti and E. Hannappel. “The dipyridyls Paraquat and diquat attenuate the interaction of G-
actin with thymosin4 “. FEBS Lett. 425 (1998) 495-498.
G. Cappelletti, M.G. Maggioni and R. Maci. 1999. Influence of MPP+ on the state of tubulin polymerisation in
NGF-differentiated PC12 cells. J. Neurosci. Res., 56: 28-35.
D. Cartelli, F. Casagrande, C.L. Busceti, D. Bucci, G. Molinaro, A. Traficante, D. Passarella, E. Giavini, G. Pezzoli,
G. Battaglia, G. Cappelletti. 2013. Microtubule alterations occur early in experimental parkinsonism and the
microtubule stabilizer Epothilone D is neuroprotective. Scientific Reports 3: 1837.
F. Calogero, S. Borrelli, G. Speciale, M.S. Christodoulou, D. Cartelli, D. Ballinari, F. Sola, C. Albanese, A.
Ciavolella, D. Passarella, G. Cappelletti, S. Pieraccini, M. Sironi. 2013. 9-Fluorenone-2-Carboxylic Acid as a
scaffold for tubulin interacting compounds. ChemPlusChem 78 (7): 663-669.
E. Riva, M. Mattarella, S. Borrelli, M.S. Christodoulou, D. Cartelli, M. Main, S. Faulkner, D. Sykes, G. Cappelletti,
J.S. Snaith, D. Passarella. 2013. Preparation of fluorescent tubulin binders. ChemPlusChem 78 (3): 222-226.
Maraschi AM, Ciammola A, Folci A, Sassone F, Ronzitti G, Cappelletti G, Silani V, Sato S, Hattori N, Mazzanti M,
Chieregatti E, Mulle C, Passafaro M, and Sassone J. 2014. Parkin regulates kainate receptors by interacting with the
GluK2 subunit. Nat Comm in press
Zito A, Cartelli D, Cappelletti G, Cariboni A, Andrews W, Parnavelas J, Poletti A, Galbiati M. 2014. Neuritin 1
promotes neuronal migration Brain Structure and Function, 219(1): 105-118.
S. Borrelli, M.S. Christodoulou, I. Ficarra, A. Silvani, G. Cappelletti, D. Cartelli, G. Damia, F. Ricci, M. Zucchetti, F.
Dosio, D. Passarella. (2014) New Class of Squalene-based releasable nanoassemblies of paclitaxel,
podophyllotoxin, camptothecin and epothilone A. European Journal of Medicinal Chemistry 85C: 179-190.
Cappelletti G, Casagrande F, Calogero A, De Gregorio C, Pezzoli G, Cartelli D. Biochem Soc Trans. 2015
Apr;43(2):292-6. doi: 10.1042/BST20150007. Linking microtubules to Parkinson's disease: the case of parkin.
PUBLICATIONS
A. Vescovi, M. Gebbia, G. Cappelletti, E.A. Parati and A. Santagostino. 1989. Interactions of manganese with
human glutathione-S-transferasi. Toxicology, 57: 183-191.
2013