Reference measurement service Activities accredited according to ISO/IEC 17025 and ISO 15195 (see certificate enclosed) and listed in JCTLM database (http://www

1. Measurement of glycated haemoglobin (HbA1c).

2. Measurement of enzymatic catalytic activities of: − alkaline phosphatase (ALP), − alanine aminotransferase (ALT), − aspartate aminotransferase (AST), − creatine kinase (CK), − gamma – glutamyltransferase (GGT), − lactate dehydrogenase (LDH).

3. Measurement of glucose.

Other available activities:

1. Certification of reference materials.

2. Evaluation of commutability of reference materials.

3. Assessment of implementation of metrological traceability of commercial systems.

4. Preparation and characterization of reference materials for minor hemoglobins.

5. Validation activities of assays for the majority of analytes measured in clinical settings.

6. Measurement by gas chromatography (GC-) and/or liquid chromatography (LC) coupled to mass spectrometry (MS) of cholesterol, mevalonate, desmosterol, oxidative cholesterol metabolites, 7-dehydrocholesterol, vegetal sterols, neuroactive steroids.

7. Measurements by LC-MS/MS of fatty acids and phospholipids.

8. Evaluation of RNA messenger (mRNA) expression involved in different pathological states.

9. Measurement of glycohydrolases activity for the diagnosis and prognosis of lysosomal enzyme deficiency diseases.