{"id":1094,"date":"2018-01-14T19:01:44","date_gmt":"2018-01-14T18:01:44","guid":{"rendered":"http:\/\/sites.unimi.it\/foodsystems\/?p=1094"},"modified":"2020-11-20T12:04:31","modified_gmt":"2020-11-20T11:04:31","slug":"phd-student-profile-luce-micaela-mattio","status":"publish","type":"post","link":"https:\/\/sites.unimi.it\/foodsystems\/2018\/01\/14\/phd-student-profile-luce-micaela-mattio\/","title":{"rendered":"PhD student profile, Luce Micaela Mattio"},"content":{"rendered":"<div class=\"entry\">\n<p><strong>PhD Student<\/strong>: Luce Micaela Mattio<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1097\" src=\"http:\/\/sites.unimi.it\/foodsystems\/wp-content\/uploads\/2018\/01\/200x200.jpg\" alt=\"200x200\" width=\"200\" height=\"200\" srcset=\"https:\/\/sites.unimi.it\/foodsystems\/wp-content\/uploads\/2018\/01\/200x200.jpg 200w, https:\/\/sites.unimi.it\/foodsystems\/wp-content\/uploads\/2018\/01\/200x200-150x150.jpg 150w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/p>\n<p><strong>Tutor<\/strong>: Prof. Sabrina Dallavalle &#8211; DeFENS<\/p>\n<p><strong>Dean<\/strong>: Prof. Ella Pagliarini<\/p>\n<p><strong>Research area<\/strong>: Chemistry and Biochemistry<\/p>\n<p><strong>Research topic: <\/strong>Sustainable chemistry for the preparation of molecules of agri-food interest<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Project Synopsis <\/strong><\/p>\n<p>My PhD project is focused on the preparation of polyphenolic compounds, in particular stilbenoids (resveratrol analogues and dimers) and flavonoids (anthocyanidins, chalcons) and their metabolites. The desired compounds will be obtained by synthetic and biocatalytic methodologies and\/or by purification procedures from selected raw materials. These molecules will be tested for their activity (antioxidant properties, immunomodulatory functions, etc) in different biological models and for their interactions with the microbiota. Structure-activity relationship studies will be performed in order to understand the modes of action of the active compounds. Moreover, new polyphenol derivatives will be designed, synthetized and evaluated for antibacterial and antifungal activity.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Project keywords <\/strong><\/p>\n<p>Chemical synthesis, biocatalysis, polyphenols, by-product<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Contacts <\/strong><\/p>\n<p><a href=\"mailto:luce.mattio@unimi.it\">luce.mattio@unimi.it<\/a> Department of Food, Environmental and Nutritional Sciences (DeFENS) \u2013 Via Celoria 2, 20133 Milano<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Collaborations<\/strong><\/p>\n<p>Prof. Andrea Pinto, Department of Food, Environment and Nutritional Sciences, UNIMI<\/p>\n<p>Prof. Diego Romano, Department of Food, Environment and Nutritional Sciences, UNIMI<\/p>\n<p>Prof. Alessandra Marti, Department of Food, Environment and Nutritional Sciences, UNIMI<\/p>\n<p>Valentina Taverniti, Department of Food, Environment and Nutritional Sciences, UNIMI<\/p>\n<p>Prof. Francesco Bonomi, Prof. Stefania Iametti, Prof. Alessio Scarafoni, Department of Food, Environment and Nutritional Sciences, UNIMI<\/p>\n<p>Dr. Stefania Arioli, Department of Food, Environment and Nutritional Sciences, UNIMI<\/p>\n<p>Prof. Jan Frederik Stevens, Linus Pauling Institute, Oregon State University<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Sponsor<\/strong><\/p>\n<p><em>Fellowship sponsor<\/em>: Universit\u00e0 degli Studi di Milano<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Publications<\/strong><\/p>\n<p>L. Mattio, L. Musso, L. Scaglioni, A. Pinto, P. A. Martino, S. Dallavalle (2018) Synthesis of a leopolic acid-inspired tetramic acid with antimicrobial activity against multidrug-resistant bacteria. <em>Beilstein J. Org. Chem.<\/em> 14, 2482-2487. DOI: <a href=\"https:\/\/doi.org\/10.3762\/bjoc.14.224\" target=\"_blank\">10.3762\/bjoc.14.224<\/a>.<\/p>\n<p>Zuccolo, S. Dallavalle, R. Cincinelli, L. Mattio, S. Mazzini, M. De Cesare, L. Musso (2019) 2-Acryloyl-4,5-methylendioxyphenol: A Small Molecule Endowed with Antidermatophytic Activity. <em>Letters in Drug Design &amp; Discovery<\/em> 16, 1-6. DOI: <a href=\"https:\/\/doi.org\/10.2174\/1570180815666180803115347\" target=\"_blank\">10.2174\/1570180815666180803115347<\/a><\/p>\n<p>L. Mattio, M. Marengo, C. Parravicini, I. Eberini, S. Dallavalle, F. Bonomi, S. Iametti, A. Pinto (2019) Inhibition of Pancreatic a-amylase by Resveratrol Derivatives: Biological Activity and Molecular Modelling Evidence for Cooperativity between Viniferin Enantiomers. <em>Molecules<\/em>, 24, 3225. DOI: <a href=\"https:\/\/doi.org\/10.3390\/molecules24183225\" target=\"_blank\">10.3390\/molecules24183225<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Poster and oral communication<\/strong><\/p>\n<p>L. Mattio, A. Pinto, S. Dallavalle, D. Romano, P. Abbasi Parizad, G. Della Scala (2018) <em>Polyphenols: chemistry, metabolites, and structure-activity relationship studies <\/em><\/p>\n<p>Oral presentation at Advanced School on \u201cFood Proteins\u201d, 2-4 May 2018, Bergamo.<\/p>\n<p>&nbsp;<\/p>\n<p>L. Mattio, S. Dallavalle (2018) <em>Synthesis and biological evaluation of resveratrol-derivatives<\/em><\/p>\n<p>Poster presentation at <em>XXIII Workshop on the developments in the Italian PhD Research on food science, technology and biotechnology<\/em>, 19-21 September 2018 \u2013 Oristano.<\/p>\n<p>&nbsp;<\/p>\n<p>L. Mattio, F. Braggio, M. Marengo, A. Scarafoni, S. Iametti, S. Dallavalle, A. Pinto (2018) <em>Structure-dependent biological activities of natural resveratrol derivatives<\/em><\/p>\n<p>Poster presentation at <em>CHIMALI \u2013 XII Italian Food Chemistry Congress<\/em>, 24-27 September 2018 \u2013 Camerino.<\/p>\n<p>&nbsp;<\/p>\n<p>Wu, I. L. Paraiso, L. Mattio, R. Reed, J. Morr\u00e9, A. F. Gombart. C. S. Maier, J.F. Stevens (2019) <em>Gut microbial and hepatic metabolism of the hop flavonoid xanthohumol in humans<\/em><\/p>\n<p>Poster presentation at <em>67<sup>th<\/sup> ASMS Conference on Mass Spectrometry and Allied Topics<\/em>, 2-6 June, 2019 \u2013 Atlanta (GA \u2013 USA).<\/p>\n<p>&nbsp;<\/p>\n<p>L. Mattio, W. Wu, K. Brown, C. Miranda, A. Vaswani, A. Alcazar Magana, J. Morr\u00e9, C. S. Maier, J.F. Stevens (2019) <em>Global natural products social molecular networking (GNPS) analysis integrated with model-predicted bioactives in hops extract<\/em><\/p>\n<p>Poster presentation at <em>Linus Pauling Institute International Conference 2019<\/em>, 14-16 August, 2019 \u2013 Corvallis (OR \u2013 USA).<\/p>\n<p>&nbsp;<\/p>\n<p>L. Mattio, W. Wu, I. L. Paraiso, R. Reed, J. Morr\u00e9, A. F. Gombart, C. S. Maier, J.F. Stevens (2019) <em>Quantitative profiling of urinary xanthohumol metabolites in humans reveals metabotypes that reflect differences in gut microbiomes<\/em><\/p>\n<p>Oral presentation at <em>13rd World Congress on Polyphenols Application<\/em>, 30th September \u2013 1 October, 2019 \u2013 La Valletta, Malta.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>PhD Student: Luce Micaela Mattio Tutor: Prof. Sabrina Dallavalle &#8211; DeFENS Dean: Prof. Ella Pagliarini Research area: Chemistry and Biochemistry Research topic: Sustainable chemistry for the preparation of molecules of agri-food interest &nbsp; Project Synopsis My PhD project is focused on the preparation of polyphenolic compounds, in particular stilbenoids (resveratrol analogues and dimers) and flavonoids &#8230;<\/p>\n","protected":false},"author":1,"featured_media":1097,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":""},"categories":[93,59],"tags":[111,187,9,91],"class_list":{"0":"post-1094","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-news","8":"category-phd-student-profile","9":"tag-biocatalysis","10":"tag-by-product","11":"tag-chemical-synthesis","12":"tag-polyphenols","13":"anons"},"modified_by":"admin","_links":{"self":[{"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/posts\/1094","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/comments?post=1094"}],"version-history":[{"count":7,"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/posts\/1094\/revisions"}],"predecessor-version":[{"id":2014,"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/posts\/1094\/revisions\/2014"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/media\/1097"}],"wp:attachment":[{"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/media?parent=1094"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/categories?post=1094"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/tags?post=1094"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}