{"id":324,"date":"2016-10-22T14:52:46","date_gmt":"2016-10-22T12:52:46","guid":{"rendered":"http:\/\/sites.unimi.it\/foodsystems\/?p=324"},"modified":"2020-11-20T12:05:52","modified_gmt":"2020-11-20T11:05:52","slug":"phd-student-profile-stefano-de-benedetti","status":"publish","type":"post","link":"https:\/\/sites.unimi.it\/foodsystems\/2016\/10\/22\/phd-student-profile-stefano-de-benedetti\/","title":{"rendered":"PhD student profile, Stefano De Benedetti"},"content":{"rendered":"<div class=\"entry\">\n<p><strong>PhD<\/strong>: Stefano De Benedetti<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-327 alignnone\" src=\"http:\/\/sites.unimi.it\/foodsystems\/wp-content\/uploads\/2016\/10\/De-Benedetti-Stefano.jpg\" alt=\"de-benedetti-stefano\" width=\"200\" height=\"199\" srcset=\"https:\/\/sites.unimi.it\/foodsystems\/wp-content\/uploads\/2016\/10\/De-Benedetti-Stefano.jpg 200w, https:\/\/sites.unimi.it\/foodsystems\/wp-content\/uploads\/2016\/10\/De-Benedetti-Stefano-150x150.jpg 150w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Tutor<\/strong>: Prof. Francesco Bonomi \u2013 DeFENS<\/p>\n<p><strong>Dean<\/strong>: Prof. Francesco Bonomi<\/p>\n<p><strong>Research area<\/strong>: Chemistry and Biochemistry<\/p>\n<p><strong>PhD title achieved on<\/strong>: 4<sup>th<\/sup> April 2017<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Research topic<\/strong><\/p>\n<p>Multidisciplinary studies of complex human diseases: from nutrition to molecular biology<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Project Synopsis<\/strong><\/p>\n<p>Multidisciplinary study of a geographic cluster of Sporadic Amyotrophic Lateral Sclerosis patients, with proteomic, metallomic, genetic and advanced multifactorial statistical analyses. The project is aimed at studying the different aspects of the disease with a particular focus to nutrition and environmental exposure. The final outcome would lead to a better understanding of the disease, by studying subjects exposed to common environmental stressors, and to propose potential nutritional interventions to manage the disease course.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Project keywords<\/strong><\/p>\n<p>environment, complex diseases, proteomics, metals<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Contacts<\/strong><\/p>\n<p>DeFENS \u2013 Division of Chemical and Biomolecular Sciences<\/p>\n<p>Via Celoria 2, 20133 Milano \u2013 Italy<\/p>\n<p><em>Phone<\/em>: +39 02 503 16823<\/p>\n<p><em>E-mail<\/em>: <a href=\"mailto:stefano.debenedetti@unimi.it\">stefano.debenedetti@unimi.it<\/a><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Collaborations<\/strong><\/p>\n<p>Prof. Elisabetta Gianazza, Laboratory of Biochemistry and Computational Biophysics, Department of Pharmacological and Biomolecular Sciences (DiSFeB), via G. Balzaretti 9, University of Milan, 20133 Milano, Italy.<\/p>\n<p>Dott.ssa Silvana Penco, Medical Genetics Unit, Department of Laboratory Medicine, Niguarda Ca&#8217; Granda Hospital, 20169, Milan, Italy.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Sponsor<\/strong><\/p>\n<p><em>Fellowship sponsor<\/em>: Universit\u00e0 degli Studi di Milano<\/p>\n<p><em>Project sponsor<\/em>: Comitato per la Fondazione Giovanni Raffo \u2013 Onlus (partially funding \u2013 recruitment of patients)<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Publications<\/strong><\/p>\n<p><strong>Stefano De Benedetti<\/strong>, Giorgio Lucchini, Alessandro Marocchi, Silvana Penco, Christian Lunetta, Stefania Iametti, Elisabetta Gianazza, Francesco Bonomi. Serum metal evaluation in a small cohort of Amyotrophic Lateral Sclerosis patients reveals high levels of thiophylic species. Peptidomics. Volume 2, Issue 1, ISSN (Online) 2084-7203, DOI: <a href=\"http:\/\/dx.doi.org\/10.1515\/ped-2015-0004\" target=\"_blank\">10.1515\/ped-2015-0004<\/a>, January 2016<\/p>\n<p>M.S. Cigoli, <strong>S. De Benedetti<\/strong>, A. Marocchi, S. Bacigaluppi, P. Primignani, G. Gesu, A. Citterio, L. Tassi, O. Mecarelli, P. Pulitano, S. Penco. A novel MGC4607\/CCM2 gene mutation associated with cerebral spinal and cutaneous cavernous angiomas. J Mol Neurosci July 2015, Volume 56, Issue 3, pp 602-607. doi: <a href=\"http:\/\/dx.doi.org\/10.1007\/s12031-015-0555-0\" target=\"_blank\">10.1007\/s12031-015-0555-0<\/a><\/p>\n<p>Cigoli MS, Avemaria F, <strong>De Benedetti S<\/strong>, Gesu GP, Accorsi LG, Parmigiani S, Corona MF, Capra V, Mosca A, Giovannini S, Notturno F, Ciccocioppo F, Volpi L, Estienne M, De Michele G, Antenora A, Bilo L, Tavoni A, Zamponi N, Alfei E, Baranello G, Riva D, Penco S. PDCD10 gene mutations in multiple cerebral cavernous malformations. PLoS One. 2014 Oct 29;9(10):e110438. doi: <a href=\"http:\/\/dx.doi.org\/10.1371\/journal.pone.0110438\" target=\"_blank\">10.1371\/journal.pone.0110438<\/a>. eCollection 2014<\/p>\n<p>&nbsp;<\/p>\n<p>XIV FISV congress. De Benedetti, G. Lucchini, A. Marocchi, S. Penco, C. Lunetta, S. Iametti, E. Gianazza, F. Bonomi. A multidisciplinary approach to study Sporadic Amyotrophic Lateral Sclerosis in patients with common geographical origin. Poster<\/p>\n<p>XXI Workshop on the Developments in the Italian PhD Research on Food Science, Technology and Biotechnology. Sporadic Amyotrophic Lateral Sclerosis in patients with common geographical origin: a multidisciplinary study. Oral presentation<\/p>\n<p>FEBS\/IUBMB Advanced lecture course Spetses 2016 &#8220;Molecular basis of human diseases: 50 years\u2019 anniversary of Spetses summer schools&#8221;. De Benedetti, G. Lucchini, A. Marocchi, S. Penco, C. Lunetta, S. Iametti, E. Gianazza, F. Bonomi. Serum metal concentrations and proteomics of ALS patients originating from a small geographical area.\u00a0Poster<\/p>\n<p>ENCALS Meeting 2016. De Benedetti, G. Lucchini, A. Marocchi, S. Penco, C. Lunetta, S. Iametti, E. Gianazza, F. Bonomi. Metal and proteomic analysis of sporadic ALS patients with common geographical origin.\u00a0Poster<\/p>\n<p>XVIII Congresso Nazionale Societ\u00e0 Italiana di Genetica Umana,\u00a0SIGU 2015. De Benedetti, G. Lucchini, A. Marocchi, C. Lunetta, S. Iametti, E. Gianazza, F. Bonomi, S. Penco. Metals concentrations in Amyotrophic Lateral Sclerosis patients originating from a restricted geographical area. Poster<\/p>\n<p>XX Workshop on the Developments in the Italian PhD Research on Food Science, Technology and Biotechnology. Metals and proteomics of the biological fluids in ALS patients: Preliminary data.\u00a0Poster<\/p>\n<p>IUBMB Symposium FeS 2015.\u00a0Iron Sulfur Cluster Biogenesis and Regulation. De Benedetti, G. Lucchini, A. Marocchi, S. Penco, S. Iametti, E. Gianazza, F. Bonomi. Metals analysis in a small cohort of ALS patients originating from a restricted geographical area: preliminary data.\u00a0Poster<\/p>\n<p>XIX Workshop on the Developments in the Italian PhD Research on Food Science, Technology and Biotechnology. Micronutrients in a Neurodegenerative Disorder such as Amyotrophic Lateral Sclerosis.\u00a0Poster<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>PhD: Stefano De Benedetti &nbsp; Tutor: Prof. Francesco Bonomi \u2013 DeFENS Dean: Prof. Francesco Bonomi Research area: Chemistry and Biochemistry PhD title achieved on: 4th April 2017 &nbsp; Research topic Multidisciplinary studies of complex human diseases: from nutrition to molecular biology &nbsp; Project Synopsis Multidisciplinary study of a geographic cluster of Sporadic Amyotrophic Lateral Sclerosis &#8230;<\/p>\n","protected":false},"author":1,"featured_media":327,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[93,59],"tags":[73,72,75,74],"class_list":{"0":"post-324","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-news","8":"category-phd-student-profile","9":"tag-complex-diseases","10":"tag-environment","11":"tag-metals","12":"tag-proteomics","13":"anons"},"modified_by":"admin","_links":{"self":[{"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/posts\/324","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/comments?post=324"}],"version-history":[{"count":9,"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/posts\/324\/revisions"}],"predecessor-version":[{"id":1222,"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/posts\/324\/revisions\/1222"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/media\/327"}],"wp:attachment":[{"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/media?parent=324"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/categories?post=324"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.unimi.it\/foodsystems\/wp-json\/wp\/v2\/tags?post=324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}