Selected publications

• Retentive device for intravesical drug delivery based on water-induced shape memory response of poly (vinyl alcohol): design concept and 4D printing feasibility. A. Melocchi, N. Inverardi, M. Uboldi, F. Baldi, A. Maroni, S. Pandini, F. Briatico-Vangosa, L. Zema, A. Gazzaniga – International Journal of Pharmaceutics, 559, 299 (2019)

• Novel hydrophilic matrix system with non-uniform drug distribution for zero-order release kinetics. M. Cerea, A. Maroni, L. Palugan, M. Bellini, A. Foppoli, A. Melocchi, L. Zema, A. Gazzaniga. Journal of Controled Release, 287, 247, (2018)

• 3D printed multi-compartment capsular devices for two-pulse oral drug delivery. A. Maroni, A. Melocchi, F. Parietti, A. Foppoli, L. Zema, A. Gazzaniga – Journal of Controlled Release, 268, 10 (2017)

• In vitro and in vivo evaluation of an oral multiple-unit formulation for colonic delivery of insulin. A. Maroni, M.D. Del Curto, S. Salmaso, L. Zema, A. Melocchi, P. Caliceti, A. Gazzaniga – European Journal of Pharmaceutics and Biopharmaceutics, 108, 76 (2016)

• Hot-melt extruded filaments based on pharmaceutical grade polymers for 3D printing by fused deposition modeling. A. Melocchi, F. Parietti, A. Maroni, A. Foppoli, A. Gazzaniga, L. Zema. – International Journal of Pharmaceutics, 509(1-2) 255 (2016)

• Influence of temperature and relative humidity conditions on the pan coating of hydroxypropyl cellulose molded capsules.  E. Macchi, L. Zema, P. Pandey, A. Gazzaniga, L.A. Felton- European Journal of Pharmaceutics and Biopharmaceutics, 100, 47 (2016)

• 3D printing by fused deposition modeling (FDM) of a swellable/erodible capsular device for oral pulsatile release of drugs. A. Melocchi, F. Parietti, G. Loreti, A. Maroni, A. Gazzaniga, L. Zema. Journal of Drug Delivery Science and Technology, 30 360 (2015)

• Impact of needle-like crystals on wet and solid-lipid extrusion processes. G. Di Pretoro, L. Zema,  A. Gazzaniga, P. Kleinebudde – Powder Technology 270 (PB) 476 (2015)

•  Inyection-Molded Capsular Device for Oral Pulsatile Release: Development of a Novel Mold. L. Zema, G. Loreti, E. Macchi, A. Foppoli, A. Maroni, A. Gazzaniga – J Pharm Sci 102, 489, (2013)

• Gastroresistant capsular device prepared by injection molding. L. Zema, G. Loreti, A. Melocchi, A. Maroni, L. Palugan, A. Gazzaniga – Int. J. Pharm. 440, 264 (2013)

• Polymeric coatings for a multiple-unit pulsatile delivery system: Preliminary study on free and applied films. A. Maroni, M.D. Del Curto, M. Cerea, L. Zema, A. Foppoli, A. Gazzaniga – Int. J. Pharm. 440, 256 (2013)

• Bioequivalenza, intercambiabilità e sostituibilità. A. Gazzaniga, A. Maroni – Giornale Italiano di Farmacoeconomia e Farmacoutilizzazione 1 (5): 21 (2013)

• Drug Delivery: Pulsatile release Systems. A. Maroni, A. Foppoli, L. Palugan, A. Gazzaniga – In Encyclopedia of Pharmaceutical Science and Technology, Fourth Edition, Vol. II. James Swarbrick, Editor. CRC Press, Taylor & Franceis Group: New York. pp 1173-1182 (2013)

• Injection Molding and its application to drug delivery. L. Zema, G. Loreti, A. Melocchi, A. Maroni, A. Gazzaniga – J. Control. Release 159, 324 (2012)

• Oral Colon Delivery of Insulin with the Aid of Functional Adjuvants. A. Maroni, L. Zema,  M.D. Del Curto, A. Foppoli, A. Gazzaniga – Adv. Drug. Deliv. 64, 540 (2012)

• Optimisation and scale up of a highly-loaded 5-ASA multiparticulate dosage form using a factorial approach. G. Di Pretoro, L. Zema, L. Palugan, D.I. Wilson, S.L. Rough, A. Gazzaniga – Eur. J. Pharm. Sci., 45(1-2), 158-168 (2012)

• Oral delivery system for two-pulse colonic release of protein drugs and protease inhibitor/absorption enhancer compounds. M.D. Del Curto., A.Maroni, L. Palugan., L. Zema, A. Gazzaniga, M.E. Sangalli – J. Pharm. Sci. 100, 3251 (2011)

• A Novel Injection-Molded Capsular Device for Oral Pulsatile Delivery Based on Swellable/Erodible Polymers. A. Gazzaniga, M. Cerea, A. Cozzi, A. Foppoli, A. Maroni, L. Zema – AAPS PharmSciTech 12, 295 (2011)

• Extrusion-spheronisation of highly-loaded 5-ASA multiparticulate dosage form. G. Di Pretoro, L. Zema, A. Gazzaniga, S.L. Rough, D.I. Wilson – Int. J. Pharm. 402, 153 (2010)

• Active packaging for topical cosmetic/drug products: A hot-melt extruded preservative delivery device. L. Zema, M.E. Sangalli, A. Maroni, A. Foppoli, A. Bettero, A. Gazzaniga – Eur. J. Pharm. Biopharm. 75, 291 (2010)

• Preparation and evaluation of an oral delivery system for time-dependent colon release of insulin and selected protease inhibitor and absorption enhancer compounds. M.D. Del Curto, A. Maroni, A. Foppoli, L. Zema, A. Gazzaniga, M.E. Sangalli – J. Pharm. Sci. 98(12), 4661 (2009)

• The use of β-cyclodextrin in the manufacturing of disintegrating pellets with improved dissolution performances. L. Zema, L. Palugan, A. Maroni, A. Foppoli, M.E. Sangalli, A. Gazzaniga – AAPS PharmSciTech 9(2), 708 (2008)

• Different HPMC Viscosity Grades as Coating Agents for an Oral Time and/or Site-Controlled Delivery System: an Investigation into the Mechanisms Governing Drug Release. L. Zema, A. Maroni, A. Foppoli, L. Palugan, M.E. Sangalli, A. Gazzaniga – J. Pharm. Sci. 96(6), 1527 (2007)

• Time-controlled oral delivery systems for colon targeting. A. Gazzaniga, A. Maroni, M.E. Sangalli, L. Zema – Exp. Opin. Drug Deliv. 3, 583 (2006)

• Polymorphism of NCX4016, an NO-Releasing Derivative of Acetylsalicylic Acid. A. Foppoli, M.E. Sangalli, A. Maroni, A. Gazzaniga, M.R. Caira, F. Giordano – J. Pharm. Sci. 93(3), 521 (2004)

• Different HPMC viscosity grades as coating agents for an oral time and/or site controlled delivery system: a study on process parameters and in vitro performances. M.E. Sangalli, A. Maroni, A. Foppoli, L. Zema, F. Giordano, A. Gazzaniga – Eur. J. Pharm. Sci. 22, 469 (2004)

• The application of ultrasonics in the assessment of the in vitro dissolution rate of powders. L. Zema, M.E. Sangalli, A. Maroni, A. Foppoli, F. Giordano, A. Gazzaniga – S.T.P. Pharma Sci., 12(3), 163 (2002)

• In vitro and in vivo evaluation of an oral system for time and/or site-specific drug delivery. M.E. Sangalli, A Maroni, L Zema, C Busetti, F Giordano, A Gazzaniga – J. Control. Release, 72(1), 103 (2001)

• Influence of betacyclodextrin on the release of poorly soluble drugs from inert and hydrophilic heterogeneous polymeric matrices. M.E. Sangalli, L Zema, A Maroni, A Foppoli, F Giordano, A Gazzaniga – Biomaterials, 22(19), 2647 (2001)

• Distribution of Kellin in excised human skin following iontophoresis and passive dermal transport. B. Marconi, F. Mancini, P. Colombo, F. Allegra, F. Giordano, A. Gazzaniga, G. Orecchia, P. Santi – J. Contr. Rel., 60, 261 (1999)

• Physical Properties of Parabens and Their Mixtures: Solubility in Water, Thermal Behavior, and Crystal Structures. F. Giordano, R. Bettini, C. Donini, A. Gazzaniga, M.R. Caira, G.G.Z. Zhang and D.J.W. Grant – J. Pharm. Sci., 88(11), 1210 (1999)

• Structural Characterization of Two Polymorphic Forms of Piroxicam Pivalate. M.R. Caira, M. Zanol, T. Peveri, A. Gazzaniga, F. Giordano – J. Pharm. Sci., 87(12), 1608 (1998)

• The use of Beta-cyclodextrin as a pelletization agent in the extrusion/spheronization process. A. Gazzaniga, M.E. Sangalli, G. Bruni, L. Zema, C. Vecchio, F. Giordano – Drug Dev. Ind. Pharm., 24(9), 869 (1998)

• Time-dependent oral delivery Systems for Colon-Targeting. A. Gazzaniga, C. Busetti, L. Moro, M.E. Sangalli, F. Giordano – S.T.P. Pharma, 5(1), 83 (1995)

• Inert monolithic device with a central hole for constant drug release. M.E. Sangalli, P. Giunchedi, L. Maggi, U. Conte, A. Gazzaniga – Eur. J. Pharm. Biopharm, 40, 370 (1994)

• Oral delayed-release system for colonic specific delivery. A. Gazzaniga, P. Iamartino, G. Maffione, M.E. Sangalli – Int. J. Pharm., 108, 77 (1994)

• Oral Chronotopic^® Drug Delivery Systems: Achievement of Time and/or Site Specificity. A. Gazzaniga, M.E. Sangalli, F. Giordano – Eur. J. Pharm. Biopharm, 40, 246 (1994)

• Oral Colon-Specific Drug Delivery: Design Strategies. A. Gazzaniga, F. Giordano, M.E. Sangalli, L. Zema – S.T.P. Pharma, 4, 336 (1994)

• On the release mechanism from coated swellable minimatrices. A. Gazzaniga, M.E. Sangalli, U. Conte, C. Caramella, P. Colombo, A. La Manna – Int. J. Pharm., 91, 167 (1993)

• High-viscosity HPMC as a film coating agent. G. Maffione, P. Iamartino, G. Guglielmini, A. Gazzaniga – Drug Dev. Ind. Pharm., 19, 2043 (1993)

• Erodible perforated coated matrix for extended release of drugs. M.E. Sangalli, P. Giunchedi, A. Gazzaniga, U. Conte – Int. J. Pharm., 91, 151 (1993)

• Influence of extrusion-spheronisation processing on the physical properties of d-Indobufen pellets containing pH adjusters. R. Bianchini, G. Bruni, A. Gazzaniga, C. Vecchio – Drug Dev. Ind. Pharm., 18, 1485 (1992)

• The influence of water content on the binding capacity of beta-cyclodextrin. F. Giordano, A. Gazzaniga, G.P. Bettinetti, A. La Manna – Int. J. Pharm., 62, 153 (1990)

• d-Indobufen extended-release pellets prepared by coating with aqueous polymer dispersions. R. Bianchini, G. Bruni, A. Gazzaniga, C. Vecchio – Drug Dev. Ind. Pharm., 19, 2021 (1993)

• Drug release modulation by physical restrictions of matrix swelling. P. Colombo, U. Conte, A. Gazzaniga, L. Maggi, M.E. Sangalli, N.A. Peppas, A. La Manna – Int. J. Pharm. 63, 43 (1990)

• Cyclodextrins as “active” excipients in tabletting technology. A. La Manna, F. Giordano, A. Gazzaniga – Proc. 5^th International Symposium on Cyclodextrins 5, 563 (1990)

• Energetics of tablet disintegration. N.A. Peppas, P. Colombo, U. Conte, A. Gazzaniga, C. Caramella, F. Ferrari – Int. J. Pharm. 51, 77 (1989)

• Drug/Polymer Matrix Swelling and Dissolution. R.S. Harland, A. Gazzaniga, M.E. Sangalli, P. Colombo, N.A. Peppas – Pharmaceutical Rersearch 5, 488 (1988)

• Swelling-Activated Drug Delivery Systems. U. Conte, P. Colombo, A. Gazzaniga, M.E. Sangalli, A. La Manna – Biomaterials 9, 489 (1988)

• A Multiple Unit Modified Release System. A. Gazzaniga, U. Conte, P. Colombo, M.E. Sangalli, C. Caramella, A. La Manna – Polymers in medicine III, Elsevier Science Publishers, Amsterdam 3, 201(1988)

• In Vitro Programmable Zero-Order Release Drug Delivery System. P. Colombo, A. Gazzaniga, C. Caramella, U. Conte, A. La Manna – Acta Pharm. Tech. 33, 15 (1987)

• Compressed polymeric mini-matrices for drug release control. P. Colombo, U. Conte, C. Caramella, A. Gazzaniga, A. La Manna – J. Control. Release 1, 283 (1985)