Research Activity of the Group
Homogenous Catalysis: a) transition metal catalysis; b) asymmetric catalysis; c) design and synthesis of supramolecular catalysts; d) development of sustainable and efficient reduction methodologies (iron catalyzed reductions, asymmetric hydrogenation of pyridines and tandem metathesis-hydrogenation processes); e) photoredox.
Main supervisor: Prof. Luca Pignataro
Medicinal Chemistry: a) Synthesis of new drug release systems (Linker-payload modules, self-immolative spacers) for targeted therapeis; b) Development of new Antibody-Drug Conjugates and other drug delivery technologies; c) Synthesis of high-affinity small molecule ligands for clinically-relevant proteins.
Main supervisor: Dr. Alberto Dal Corso
News
Latest Publications
"Amine-Carbamate Self-Immolative Spacers Counterintuitively Release 3° Alcohol at Much Faster Rates than 1° Alcohol Payloads" - M. Mason, A. Dal Corso et al. ChemBioChem 2024, DOI: 10.1002/cbic.202400174
"Ex vivo mass spectrometry-based biodistribution analysis of an antibody-Resiquimod conjugate bearing a protease-cleavable and acid-labile linker" - L. Bisbal Lopez, A. Dal Corso et al. Front. Pharmacol. 2023, DOI: 10.3389/fphar.2023.1320524