Homogeneous transition metal catalysis: i) asymmetric catalysis; ii) design and synthesis of supramolecular catalysts; iii) development of sustainable and efficient reduction methodologies (iron catalyzed reductions, asymmetric hydrogenation of pyridines and tandem metathesis-hydrogenation processes).
Synthesis of targeted cytotoxic agents: development of new peptide / peptidomimetic ligands of tumor-associated receptors (e.g. integrins and vascular endothelial growth factor receptors) and their conjugation to cytotoxic, pro-apoptotic or fluorescent compounds for tumor diagnosis and therapy.
"Functionalized 2‐Hydroxybenzaldehyde‐PEG Modules as Portable Tags for the Engagement of Protein Lysine ε‐Amino Groups" - G. Sacco, A. Dal Corso, C. Gennari et al. Eur. J. Org. Chem. 2021, DOI: 10.1002/ejoc.202100160.
"Multimeric Presentation of RGD Peptidomimetics Enhances Integrin Binding and Tumor Cell Uptake" - A. Pina, C. Gennari, D. Boturyn, et al. Chem. Eur. J. 2020, DOI: 10.1002/chem.202001115.