Homogeneous transition metal catalysis: i) asymmetric catalysis; ii) design and synthesis of supramolecular catalysts; iii) development of sustainable and efficient reduction methodologies (iron catalyzed reductions, asymmetric hydrogenation of pyridines and tandem metathesis-hydrogenation processes).
Synthesis of targeted cytotoxic agents: development of new peptide / peptidomimetic ligands of tumor-associated receptors (e.g. integrins and vascular endothelial growth factor receptors) and their conjugation to cytotoxic, pro-apoptotic or fluorescent compounds for tumor diagnosis and therapy.
"Multimeric Presentation of RGD Peptidomimetics Enhances Integrin Binding and Tumor Cell Uptake" - A. Pina, C. Gennari, D. Boturyn, et al. Chem. Eur. J. 2020, DOI: 10.1002/chem.202001115.
"Recent Catalytic Applications of (Cyclopentadienone)iron Complexes" - L. Pignataro, C. Gennari, Eur. J. Org. Chem. 2020, DOI: 10.1002/ejoc.201901925.