Homogeneous transition metal catalysis: i) asymmetric catalysis; ii) design and synthesis of supramolecular catalysts; iii) development of sustainable and efficient reduction methodologies (iron catalyzed reductions, asymmetric hydrogenation of pyridines and tandem metathesis-hydrogenation processes).
Synthesis of targeted cytotoxic agents: development of new peptide / peptidomimetic ligands of tumor-associated receptors (e.g. integrins and vascular endothelial growth factor receptors) and their conjugation to cytotoxic, pro-apoptotic or fluorescent compounds for tumor diagnosis and therapy.
"A Trifunctional Self-Immolative Spacer Enables Drug Release with Two Non-Sequential Enzymatic Cleavages" - A. Dal Corso, C. Gennari et al. Chem. Commun. 2021, DOI: 10.1039/D1CC02895B.
"Functionalized 2‐Hydroxybenzaldehyde‐PEG Modules as Portable Tags for the Engagement of Protein Lysine ε‐Amino Groups" - G. Sacco, A. Dal Corso, C. Gennari et al. Eur. J. Org. Chem. 2021, DOI: 10.1002/ejoc.202100160.