Homogeneous transition metal catalysis: i) asymmetric catalysis; ii) design and synthesis of supramolecular catalysts; iii) development of sustainable and efficient reduction methodologies (iron catalyzed reductions, asymmetric hydrogenation of pyridines and tandem metathesis-hydrogenation processes).
Synthesis of targeted cytotoxic agents: development of new peptide / peptidomimetic ligands of tumor-associated receptors (e.g. integrins and vascular endothelial growth factor receptors) and their conjugation to cytotoxic, pro-apoptotic or fluorescent compounds for tumor diagnosis and therapy.
"β-Glucuronidase triggers extracellular MMAE release from an integrin-targeted conjugate" - P. López Rivas, C. Gennari et al. Org. Biomol. Chem. 2019, DOI: 10.1039/C9OB00617F.
"Synthesis and Biological Evaluation of RGD and isoDGR–Monomethyl Auristatin Conjugates Targeting Integrin αVβ3" - A. Raposo Moreira Dias, L. Bodero, C. Gennari, U. Piarulli et al. ChemMedChem 2019, DOI: 10.1002/cmdc.201900049.