{"id":155,"date":"2019-04-06T16:55:03","date_gmt":"2019-04-06T14:55:03","guid":{"rendered":"https:\/\/sites.unimi.it\/pallab\/?page_id=155"},"modified":"2023-10-20T15:39:53","modified_gmt":"2023-10-20T13:39:53","slug":"research","status":"publish","type":"page","link":"https:\/\/sites.unimi.it\/pallab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"color: #333333;\">Our research interests range from medicinal chemistry to chemical biology, with the unifying goal of developing small molecule to understand and manipulate biological systems relevant to diseases.<\/span><br><span style=\"color: #333333;\">As chemists, we are passionate about sustainability. We have a special interest in developing green chemistry methodologies and sustainable processes.<\/span><\/p>\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n<h3><span style=\"color: #ff6600;\">Medicinal Chemistry Projects<\/span><\/h3>\n<h4><img loading=\"lazy\" class=\"wp-image-1150 alignleft\" src=\"https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/Immagine6-123x300.png\" alt=\"\" width=\"170\" height=\"415\" srcset=\"https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/Immagine6-123x300.png 123w, https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/Immagine6-631x1536.png 631w, https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/Immagine6-444x1080.png 444w, https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/Immagine6.png 1013w\" sizes=\"(max-width: 170px) 100vw, 170px\" \/>\u03b17 and \u03b19\u03b110 Nicotinic Acetylcholine Receptor Ligands<\/h4>\n<p style=\"text-align: justify;\"><span style=\"color: #333333;\">Among other functions, peripheral a7 and a9a10 nicotinic receptors are involved in tumour promotion and progression. Aiming at developing novel antitumoral agents, we are carrying out a SAR campaign starting from an in-house a7 and a9a10 antagonist with good antiglioblastoma activity as lead compound.<\/span><\/p>\n<h4 id=\"mce_5\" class=\"editor-rich-text__tinymce mce-content-body\" role=\"textbox\" contenteditable=\"true\" aria-label=\"Scrivi titolo\u2026\" aria-autocomplete=\"list\" aria-multiline=\"true\" data-is-placeholder-visible=\"false\">\u03b14\u03b22 Nicotinic Acetylcholine Receptor Ligands<\/h4>\n<p class=\"has-text-color has-very-dark-gray-color\" style=\"text-align: justify;\">Nicotine causes nicotine addiction by activating the \u03b14\u03b22 nicotinic receptors in the brain. Thanks to our MedChem long-lasting expertise on this subtype, we are currently developing novel \u03b14\u03b22 partial agonist, to fight nicotine addiction and as cognition enhancers.<\/p>\n<p class=\"has-text-color has-very-dark-gray-color\" style=\"text-align: justify;\"><strong>In details we perform:<\/strong><\/p>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"color: #000000;\">Computer-aided ligand design<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"color: #000000;\">Synthesis and characterization of small molecules as ligands or probes.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"color: #000000;\">Biological characterization (external collaboration)<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"color: #000000;\">SAR interpretation<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"color: #000000;\">Molecular modelling and docking<\/span><\/li>\n<\/ul>\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n<h3><span style=\"color: #3366ff;\">Chemical Biology Projects<\/span><\/h3>\n<h4><strong>GoodIVA<\/strong><\/h4>\n<p><img loading=\"lazy\" class=\" wp-image-1146 alignright\" src=\"https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/Immagine-2022-10-10-142020-300x300.jpg\" alt=\"\" width=\"277\" height=\"277\" srcset=\"https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/Immagine-2022-10-10-142020-300x300.jpg 300w, https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/Immagine-2022-10-10-142020-150x150.jpg 150w, https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/Immagine-2022-10-10-142020.jpg 507w\" sizes=\"(max-width: 277px) 100vw, 277px\" \/><span style=\"color: #000000;\">Our brand-new interdipartimental project about photo-activable control of HCN channels has just been funded. Irradiation of photo-responsive molecules allows to activate them with high spatiotemporal control, granting a fine-tuning of the biological activity.<\/span><\/p>\n<h4>Others<\/h4>\n<p><span style=\"color: #333333;\"><img loading=\"lazy\" class=\" wp-image-1147 alignleft\" src=\"https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/Immagine-2022-10-10-142126-300x300.jpg\" alt=\"\" width=\"136\" height=\"136\" srcset=\"https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/Immagine-2022-10-10-142126-300x300.jpg 300w, https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/Immagine-2022-10-10-142126-1024x1021.jpg 1024w, https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/Immagine-2022-10-10-142126-150x150.jpg 150w, https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/Immagine-2022-10-10-142126-768x766.jpg 768w, https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/Immagine-2022-10-10-142126.jpg 1051w\" sizes=\"(max-width: 136px) 100vw, 136px\" \/>We are excited to walk toward the new (for us) field of chemical biology! Fluorescence, light and proteins we&#8217;re coming!<\/span><\/p>\n<p>\u00a0<\/p>\n<p style=\"text-align: center;\">&#8230;to be continued&#8230;<\/p>\n<p>\u00a0<\/p>\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n<h3><span style=\"color: #339966;\">Green Chemistry and Circular Economy<\/span><\/h3>\n<h4>Renewable polymeric catalysts and green solvents<\/h4>\n<p style=\"text-align: justify;\"><span style=\"color: #333333;\">Many advances in the field of polymeric catalysts have opened huge opportunities in chemistry. Aiming at unlocking new synthetic strategies, our research group is interested in the development of new sustainable polymeric catalysts. Furthermore, we develop and optimize eco-friendly protocols to produce widely used building blocks, such as amino acid benzyl esters, or to perform very useful and routinely used reactions, like reductive amination, replacing the use of banned solvents with green solvents and conditions.<\/span><\/p>\n<h4 style=\"text-align: justify;\">Waste resources exploitation\u00a0<\/h4>\n<p style=\"text-align: justify;\"><span style=\"color: #333333;\"><img loading=\"lazy\" class=\" wp-image-1148 alignleft\" src=\"https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/00-cover-circulareconomy_last_sez-300x250.jpg\" alt=\"\" width=\"135\" height=\"112\" srcset=\"https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/00-cover-circulareconomy_last_sez-300x250.jpg 300w, https:\/\/sites.unimi.it\/pallab\/wp-content\/uploads\/2022\/10\/00-cover-circulareconomy_last_sez.jpg 372w\" sizes=\"(max-width: 135px) 100vw, 135px\" \/><span style=\"color: #000000;\">Turning waste into high value material: this is the future for European industries. <\/span><\/span><br \/><span style=\"color: #000000;\">In recent years, Fondazione Cariplo funded our project regarding the extraction of\u00a0 fatty acids from lanolin and their convertion into functionalized \u03b1 -hydroxy acids, an important and high value component of cosmetics. In 2023 we won a PRIN call for the application of the same principles to spent coffee grounds. Stay tuned!<\/span><\/p>\n<p>\u00a0<\/p>\n\n\n<hr class=\"wp-block-separator has-css-opacity\"\/>\n\n\n<h3><span style=\"color: #800080;\">Stereotechnologies applied to bioactive molecules<\/span><\/h3>\n<p style=\"text-align: justify;\"><span style=\"color: #333333;\">Chirality and medicinal chemistry often go hand-in-hand. Many theorical and technical questions about chirality await for an answer or for innovative solutions. Our research group in the last 20 years has developed strong theorical and pratical expertises in this field and we are currently very interested in studying the intimate nature of enantiomeric and diasteromeric systems, in investigating and interpreting their different biological activities and in finding new innovative solutions to resolve these problems.<\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>Our research interests range from medicinal chemistry to chemical biology, with the unifying goal of developing small molecule to understand and manipulate biological systems relevant to diseases.As chemists, we are passionate about sustainability. We have a special interest in developing green chemistry methodologies and sustainable processes. Medicinal Chemistry Projects \u03b17 and \u03b19\u03b110 Nicotinic Acetylcholine Receptor&hellip; <br \/> <a class=\"read-more\" href=\"https:\/\/sites.unimi.it\/pallab\/research\/\">Leggi tutto<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.unimi.it\/pallab\/wp-json\/wp\/v2\/pages\/155"}],"collection":[{"href":"https:\/\/sites.unimi.it\/pallab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.unimi.it\/pallab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.unimi.it\/pallab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.unimi.it\/pallab\/wp-json\/wp\/v2\/comments?post=155"}],"version-history":[{"count":77,"href":"https:\/\/sites.unimi.it\/pallab\/wp-json\/wp\/v2\/pages\/155\/revisions"}],"predecessor-version":[{"id":1218,"href":"https:\/\/sites.unimi.it\/pallab\/wp-json\/wp\/v2\/pages\/155\/revisions\/1218"}],"wp:attachment":[{"href":"https:\/\/sites.unimi.it\/pallab\/wp-json\/wp\/v2\/media?parent=155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}