{"id":25492,"date":"2020-10-22T17:18:57","date_gmt":"2020-10-22T15:18:57","guid":{"rendered":"https:\/\/sites.unimi.it\/passalab\/?page_id=25492"},"modified":"2023-11-06T21:19:49","modified_gmt":"2023-11-06T20:19:49","slug":"research-projects","status":"publish","type":"page","link":"https:\/\/sites.unimi.it\/passalab\/research-projects\/","title":{"rendered":"Research Line"},"content":{"rendered":"\n
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Research Projects<\/h1><\/div>

in Organic and Bioorganic Chemistry<\/p><\/div><\/div><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n

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Synthesis of Self-Assembled Nanoparticles<\/strong> and Drug Conjugates<\/strong><\/h2>\n\n\n\n
  1. 2-Hydroxyoleic Acid as a Self-Assembly Inducer for Anti-Cancer Drug-Centered Nanoparticles<\/em><\/a><\/strong><\/li>
  2. Folic acid functionalization for targeting self-assembled paclitaxel-based nanoparticles<\/em><\/a><\/strong><\/li>
  3. Self-assembling Releasable Thiocolchicine\u2013Diphenylbutenylaniline Conjugates<\/em><\/a><\/strong><\/li>
  4. Nanolipid-Trehalose Conjugates and Nano-Assemblies as Putative Autophagy Inducers<\/em><\/a><\/strong><\/li><\/ol>\n<\/div>\n\n\n\n
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    Total Synthesis of Natural Products<\/strong><\/strong><\/h2>\n\n\n\n
    1. Stereoselective Synthetic Strategies to (\u2212)-Cannabidiol<\/strong><\/em><\/a><\/strong><\/li>
    2. Total Synthesis of (\u2212)-Cannabidiol-C4<\/sub><\/em><\/a><\/strong><\/li>
    3. Recent advances in the development of CB1<\/sub>R selective probes<\/em><\/a><\/strong><\/li><\/ol>\n\n\n\n

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      Synthesis of SARS-CoV-2 Mpro<\/sup><\/strong> Inhibitors with Anticoronavirus Activity<\/strong><\/strong><\/h2>\n\n\n\n
      1. Synthesis of SARS-CoV-2 Mpro<\/sup><\/small> inhibitors bearing a cinnamic ester warhead with in vitro<\/em> activity against human coronaviruses<\/strong><\/em><\/a><\/strong><\/li>
      2. Discovery of a Novel Trifluoromethyl Diazirine Inhibitor of SARS-CoV-2 Mpro<\/sup><\/em><\/a><\/strong><\/li>
      3. Recent Advances in SARS-CoV-2 Main Protease Inhibitors: From Nirmatrelvir to Future Perspectives<\/em><\/a><\/strong><\/li><\/ol>\n<\/div>\n\n\n\n
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        Strategies for PROTAC Development<\/strong><\/strong><\/strong><\/h2>\n\n\n\n
        1. <\/strong><\/strong><\/em><\/a>Synthesis and Preliminary Characterization of Putative Anle138b-Centered PROTACs against \u03b1-Synuclein Aggregation<\/em><\/a><\/strong><\/strong><\/em><\/strong><\/li><\/ol>\n\n\n\n

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          New Tools for the Treatment of Neurodegenerative Diseases<\/strong><\/strong><\/h2>\n\n\n\n
          1. Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis<\/strong><\/em><\/a><\/strong><\/li>
          2. Synthesis and Characterization of Edaravone Analogues as Remyelinating Agents and Putative Mechanistic Probes<\/em><\/a><\/strong><\/li><\/ol>\n<\/div>\n\n\n\n
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            Development of Robust Methodologies Involving Boronic Acids<\/strong><\/strong><\/strong><\/h2>\n\n\n\n
            1. <\/a>Highly diastereoselective entry to chiral oxindole-based \u03b2-amino boronic acids and spiro derivatives<\/em><\/a><\/strong><\/strong><\/em><\/strong><\/li>
            2. Exploiting Enantiopure \u03b2-Amino Boronic Acids in Isocyanide-Based Multicomponent Reactions<\/em><\/a><\/strong><\/em><\/strong><\/li>
            3. Computational Design, Synthesis, and Biophysical Evaluation of \u03b2-Amido Boronic Acids as SARS-CoV-2 Mpro<\/sup> Inhibitors<\/em><\/a><\/strong><\/em><\/strong><\/li>
            4. Enantiopure \u03b2-isocyano-boronic esters: synthesis and exploitation in isocyanide-based multicomponent reactions<\/em><\/a><\/strong><\/em><\/strong><\/li><\/ol>\n\n\n\n

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              Chemoselective Methodologies for the Functionalization of Pyridine and other N-Hetherocycles<\/strong><\/h2>\n\n\n\n
              1. Late-Stage Functionalisation of Pyridine-Containing Bioactive Molecules: Recent Strategies and Perspectives<\/strong><\/em><\/a><\/strong><\/li><\/ol>\n<\/div>\n\n\n\n
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                Biochemical Modulation of D-Asp Metabolism in Brain<\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n\n
                1. <\/a>Human D-aspartate Oxidase: A Key Player in D-aspartate Metabolism<\/em><\/a><\/strong><\/strong><\/em><\/strong><\/li><\/ol>\n\n\n\n

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                  …and soon to be started:<\/em><\/p>\n\n\n\n

                  • Intestinal organoid-based models for drug discovery in pediatric inflammatory bowel disease (MUR- PRIN 2022)<\/li><\/ul>\n\n\n\n
                    • Validation of therapeutic candidates targeting HMGB1 to counteract muscular dystrophy (Telethon Round 3 2023, submitted)<\/li><\/ul>\n<\/div><\/section>\n\n\n\n

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