{"id":25588,"date":"2020-10-28T13:07:54","date_gmt":"2020-10-28T12:07:54","guid":{"rendered":"https:\/\/sites.unimi.it\/passalab\/?page_id=25588"},"modified":"2020-11-30T10:25:45","modified_gmt":"2020-11-30T09:25:45","slug":"diversity-oriented-synthesis","status":"publish","type":"page","link":"https:\/\/sites.unimi.it\/passalab\/diversity-oriented-synthesis\/","title":{"rendered":"Diversity-Oriented Synthesis"},"content":{"rendered":"\n
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Diversity-Oriented
Synthesis<\/h1><\/div>
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Our continuous interest in the field of chemical approaches to target cancer cells<\/strong> moved us to study the preparation of a novel classes of conjugate compounds using anticancer drugs as building blocks. We used squalene tail as self-assembling inducer<\/strong>1<\/sup> and a disulphide containing linker to secure the release of the drugs<\/strong> after cell internalization.2<\/sup> Subsequently we demonstrated the possibility to generate hetero and fluorescent nanoparticles<\/strong> by mixing a paclitaxel-squalene conjugate and fluorescein-squalene conjugate.3<\/sup> In the light of facing the high demanding issue of resistance4<\/sup> we studied the formation of cyclopamine-paclitaxel containing nanoparticles and we detected the cell internalization<\/strong> by confocal microscopy and super-resolution.5<\/sup> More recently we reported doxorubicin-cyclopamine hetero-nanoparticles that are able to reduce tumour growth and to decrease the toxicity of chemotherapy in mice.6<\/sup> We also applied the same approach to obtain trehalose conjugates and nano-assemblies to face neurodegeneration<\/strong>.7<\/sup><\/p>\n\n\n\n

Our efforts are actually focused on: a)<\/strong><\/em> new combination of drugs to overcome drug resistance,8<\/sup> b)<\/em> new drug-conjugates deriving by modification of active natural products,9<\/sup><\/strong>and c)<\/em> new self-assembling inducers.10,11<\/sup><\/strong><\/p>\n\n\n\n

In the field of DOS, different efforts were made in our laboratory in the last years and we are continuing the exploration of  the chemical space.<\/p>\n\n\n\n

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References<\/strong>
[1] S. L. Schreiber, Science 2000<\/strong>, 287<\/em>, 1964\u20131969.
[2] D. R. Spring, Org. Biomol. Chem.<\/em> 2003<\/strong>, 1<\/em>, 3867\u20133870
[3] E. Bonandi, D. Passarella et al. Molecules<\/em> 2020<\/strong>, 25<\/em>, 1057; doi.org\/10.3390\/molecules25051057
[4] E. Bonandi, P. Marzullo, D. Passarella et al.<\/em> Eur J. Org. Chem.<\/em> 2019<\/strong>, 2019<\/em>, 4013-4019<\/p>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-25588","page","type-page","status-publish","hentry"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"Beatrice Ricci","author_link":"https:\/\/sites.unimi.it\/passalab\/author\/beatricericci\/"},"uagb_comment_info":0,"uagb_excerpt":null,"_links":{"self":[{"href":"https:\/\/sites.unimi.it\/passalab\/wp-json\/wp\/v2\/pages\/25588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.unimi.it\/passalab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.unimi.it\/passalab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.unimi.it\/passalab\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.unimi.it\/passalab\/wp-json\/wp\/v2\/comments?post=25588"}],"version-history":[{"count":13,"href":"https:\/\/sites.unimi.it\/passalab\/wp-json\/wp\/v2\/pages\/25588\/revisions"}],"predecessor-version":[{"id":26119,"href":"https:\/\/sites.unimi.it\/passalab\/wp-json\/wp\/v2\/pages\/25588\/revisions\/26119"}],"wp:attachment":[{"href":"https:\/\/sites.unimi.it\/passalab\/wp-json\/wp\/v2\/media?parent=25588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}