{"id":27169,"date":"2024-11-08T09:39:12","date_gmt":"2024-11-08T08:39:12","guid":{"rendered":"https:\/\/sites.unimi.it\/passalab\/?p=27169"},"modified":"2024-11-08T09:39:14","modified_gmt":"2024-11-08T08:39:14","slug":"synthesis-of-%ce%b1-fluorocinnamate-derivatives-as-novel-cathepsin-s-inhibitors-with-in-vitro-antiproliferative-activity-against-pancreatic-cancer-cells","status":"publish","type":"post","link":"https:\/\/sites.unimi.it\/passalab\/2024\/11\/08\/synthesis-of-%ce%b1-fluorocinnamate-derivatives-as-novel-cathepsin-s-inhibitors-with-in-vitro-antiproliferative-activity-against-pancreatic-cancer-cells\/","title":{"rendered":"Synthesis of \u03b1-fluorocinnamate derivatives as novel cathepsin S inhibitors with in vitro antiproliferative activity against pancreatic cancer cells"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/id.elsevier.com\/as\/authorization.oauth2?platSite=SD%2Fscience&amp;additionalPlatSites=GH%2Fgeneralhospital%2CMDY%2Fmendeley%2CSC%2Fscopus%2CRX%2Freaxys&amp;scope=openid%20email%20profile%20els_auth_info%20els_idp_info%20els_idp_analytics_attrs%20urn%3Acom%3Aelsevier%3Aidp%3Apolicy%3Aproduct%3Ainst_assoc&amp;response_type=code&amp;redirect_uri=https%3A%2F%2Fwww.sciencedirect.com%2Fuser%2Fidentity%2Flanding&amp;authType=SINGLE_SIGN_IN&amp;prompt=none&amp;client_id=SDFE-v4&amp;state=retryCounter%3D0%26csrfToken%3D0163e55a-6ddd-4331-87ea-24c45378b170%26idpPolicy%3Durn%253Acom%253Aelsevier%253Aidp%253Apolicy%253Aproduct%253Ainst_assoc%26returnUrl%3D%252Fscience%252Farticle%252Fpii%252FS0968089624004012%253Fvia%25253Dihub%26prompt%3Dnone%26cid%3Darp-efc39a08-7a93-4aae-9c1e-66e5a5007467\" data-type=\"link\" data-id=\"https:\/\/id.elsevier.com\/as\/authorization.oauth2?platSite=SD%2Fscience&amp;additionalPlatSites=GH%2Fgeneralhospital%2CMDY%2Fmendeley%2CSC%2Fscopus%2CRX%2Freaxys&amp;scope=openid%20email%20profile%20els_auth_info%20els_idp_info%20els_idp_analytics_attrs%20urn%3Acom%3Aelsevier%3Aidp%3Apolicy%3Aproduct%3Ainst_assoc&amp;response_type=code&amp;redirect_uri=https%3A%2F%2Fwww.sciencedirect.com%2Fuser%2Fidentity%2Flanding&amp;authType=SINGLE_SIGN_IN&amp;prompt=none&amp;client_id=SDFE-v4&amp;state=retryCounter%3D0%26csrfToken%3D0163e55a-6ddd-4331-87ea-24c45378b170%26idpPolicy%3Durn%253Acom%253Aelsevier%253Aidp%253Apolicy%253Aproduct%253Ainst_assoc%26returnUrl%3D%252Fscience%252Farticle%252Fpii%252FS0968089624004012%253Fvia%25253Dihub%26prompt%3Dnone%26cid%3Darp-efc39a08-7a93-4aae-9c1e-66e5a5007467\"><em>Bioorganic &amp; Medicinal Chemistry<\/em> <strong>2024<\/strong>, <em>115<\/em>, 117987<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Andrea Citarella*, Serena Petrella, Davide Moi, Alessandro Dimasi, Tommaso Braga, Lorenzo Ruberto, Stefano Pieraccini, Maurizio Sironi, Nicola Micale, Tanja Schirmeister, Giovanna Damia, Valerio Fasano, Alessandra Silvani, Clelia Giannini and Daniele Passarella<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bioorganic &amp; Medicinal Chemistry 2024, 115, 117987 Andrea Citarella*, Serena Petrella, Davide Moi, Alessandro Dimasi, Tommaso Braga, Lorenzo Ruberto, Stefano Pieraccini, Maurizio Sironi, Nicola Micale, Tanja Schirmeister, Giovanna Damia, Valerio Fasano, Alessandra Silvani, Clelia Giannini and Daniele Passarella<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-27169","post","type-post","status-publish","format-standard","hentry","category-senza-categoria"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false},"uagb_author_info":{"display_name":"Zlata Boiarska","author_link":"https:\/\/sites.unimi.it\/passalab\/author\/zlataboiarska\/"},"uagb_comment_info":0,"uagb_excerpt":"Bioorganic &amp; 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