________________________________________________________
V Meeting
on the
MOLECULAR
MECHANISMS OF NEURODEGENERATION
Aula Magna, Universita' degli Studi di Milano
Via Festa del Perdono 7 - 20122 Milano (Italy)
May 13-15, 2011
FINAL
PROGRAM
Friday, May 13, 2011 (Morning)
09:30
Registration
10:00
Satellite symposium on:
Molecular
Mechanisms on Neurodevelopment
New
insights on synapse development and function
(no
registration required for this symposium)
Chairpersons: Roberto Maggi
(Italy), Fabio Benfenati (Italy)
Plenary Lecture
10:15-11:00 Fabio Benfenati
"The
key actors of synapse function and plasticity"
Session
11:00-11:30 Michela Matteoli
"From
filopodia to synapsis: the cell biology of neuronal wiring"
11:30-12:00 Alexander Dityatev
"The
dual role of the extracellular matrix in synaptic plasticity and
homeostasis"
12:00-12:30 Carlo Sala
"Molecular
organization and function of scaffold proteins at neuronal synapses"
V Meeting
on the
MOLECULAR
MECHANISMS OF NEURODEGENERATION
Friday,
May 13, 2011 (Afternoon)
Opening
Session
14:00-14:30 Introduction
by the organizers
Angelo Poletti, Elena Cattaneo, Franco
Taroni (Italy)
Prof. Fabio Celotti
(Director of the DEFIB,
Universita' degli Studi di Milano)
Prof. Ferdinando Cornelio
(Scientific
Director of the Fondazione IRCCS Istituto Neurologico "Carlo Besta",
Milano)
Kenneth H. Fischbeck (USA) and Albert La Spada (USA)
"Of
thesis committees, birthday gels, and dubious reviewers: A personal recollection of the
discovery of the first repeat expansion mutation"
Opening
lecture
14:30-15:30 Harry Orr (USA)
"Polyglutamine disorders 20 years later"
Introduced
by Kenneth H.
Fischbeck
Session I:
Cellular handling of aberrant neurotoxic proteins I
Chairpersons:
Harry Orr (USA), Michela Matteoli (Italy)
15:30-16:00 Ralph A. Nixon (USA)
"Autophagy Failure in Alzheimer's Disease"
16:00-16:30 Kenneth H Fischbeck (USA)
"Therapeutic
approaches to Spinal and Bulbar Muscular Atrophy"
16:30-17:00 Coffee break
Session II:
Cellular handling of aberrant neurotoxic proteins II
Chairpersons:
Harry Orr (USA), Michela Matteoli (Italy)
17:00-17:30 Francesco Cecconi (Italy)
"Caspase-3 triggers early synaptic
dysfunction in a mouse model of Alzheimer's Disease"
17:30-18:00 Sandrine Humbert (France)
"Huntington's
disease and beta-catenin homeostasis"
18:00-19.30 Selected
Oral Presentations
Chairpersons:
Roberto Maggi (Italy), Giorgio Battaglia (Italy)
OC-1
"USP14 functions in a non-catalytic manner to regulate synaptic
activity"
Walters
BJ, Dobrunz LE and Wilson SM (USA)
OC-2 "The role of Parkinson's
disease associated Pink1 in the quality control mechanisms of mitochondrial
dynamics and autophagy"
Mai
S, Klinkenberg M, Auburger G, Bereiter-Hahn J, Jendrach M (Germany)
OC-3
"Identification of drosophila ortholog of HSPB8: implication of HspB8 loss
of function in protein folding disease"
Boncoraglio
A, Kanon B, Brunsting JF, Minoia M, Rana A, Vos MJ, Seidel K, Sibon OCM,
Kampinga HH and Carra S (The Netherlands)
OC-4
"Pharmacological and molecular approaches to remove mutant misfolded
androgen receptor in spinal and bulbar muscular atrophy"
Rusmini
P, Crippa V, Giorgetti E, Sau D, Poletti A (Italy)
OC-5 "In vitro drug
treatments aimed at rescuing the correct nuclear localization and
transactivating function of polyala expanded PHOX2B proteins"
Di
Zanni E, Bachetti T, Bocca P, Prigione I, Di Lascio S, Fornasari D,
Ravazzolo R, Ceccherini I (Italy)
OC-6 "Involvement of
peroxisomes in early hippocampal neurodegeneration in a transgenic mouse model
of Alzheimer's disease"
Fanelli
F, D'Angelo B, Benedetti E, Sepe S, Cristiano L, D'Amelio M, Bernardi C,
Cecconi F, Cimini A, Cer MP, Moreno S (Italy)
19:30 Welcome
Party
Saturday, May 14, 2011 (Morning)
08:30-10:00 Selected
Oral Presentations
Chairpersons:
Fabrizio Tagliavini (Italy), Caterina Mariotti (Italy)
OC-7
"ER-mitochondria Ca2+ cross-talk in AD: (FAD-)PS2 tightens the link"
Zampese
E, Filadi R, Kipanyula MJ, Capitanio P, Pozzan T, Fasolato C, and Pizzo P
(Italy)
OC-8
"Selective intracellular targeting and interference of Alzheimer's amyloid
beta oligomers with conformational intrabodies"
Meli
G, Lecci A, Krako N, Manca A, Albertini V, Ghidoni R, Cattaneo A (Italy)
OC-9
"Misfolded protein oligomers formed by a model protein mimic the effect of
A-beta oligomers on synaptic plasticity involved in Alzheimer's disease"
Tatini
F, Pugliese AM, Traini C, Niccoli S, Maraula G, Eddami T, Mannini B, Pedata
F, Casamenti F, Chiti F (Italy)
OC-10
"Prodynorphin mutations cause the neurodegenerative disorder
spinocerebellar ataxia type 23"
Bakalkin
G, Jezierska J, Watanabe H, Depoorter C, Bazov I, Verschuuren-Bemelmans C,
Artemenko KA, Van de Warrenburg BPC, Hauser KF, Sinke RJ and Verbeek DS (The Netherlands)
OC-11
"Analysis of staminal and neuronal microRNA expression in spinal cord and
ependymal stem cells from G93A-SOD1 amyotrophic lateral sclerosis mice"
Marcuzzo
S, Tartari S, Cavalcante P, Bonanno S, Cappelletti C, Bernasconi P,
Mantegazza R (Italy)
OC-12
"Reversal of reduced neuronal and BDNF gene transcription in HD mice by
dominant negative REST"
Conforti
P, Mas Montes A, Zuccato C, Soldati C, Buckely N, Davidson B, Cattaneo E
(Italy)
Session III: Non cell autonomous
toxicity I
Chairpersons:
Mario Salmona (Italy), Angelo Poletti (Italy)
10:00-10:30 Jochen Herms
(Germany)
"Kinetics of A§-plaque formation and spine loss in Alzheimer's disease:
Long-term in vivo two-photon imaging studies in transgenic mouse models"
10:30-11:00 Marta
Valenza (Italy)
"Emerging roles for
cholesterol in HuntingtonÕs disease"
11:00-11:30 Coffee
break
Session IV: Non cell autonomous
toxicity II
Chairpersons:
Mario Salmona (Italy), Angelo Poletti (Italy)
11:30-12:00 Antonio
Musaro' (Italy)
"The contribution of skeletal
muscle to the pathogenesis of ALS"
12:00-12:30
Maria
Pennuto (Italy)
"Phosphorylation of polyglutamine
androgen receptor in skeletal muscle attenuates disease manifestations in SBMA
mice"
12:30-13:30 Lunch
Saturday,
May 14, 2011 (Afternoon)
13:30-15:00
Poster Session A (P-A.01 / P-A.48)
15:00-16:00
Andrea
Ballabio (Italy)
"Modulating
cellular clearance in neurodegenerative diseases"
Introduced
by Larry Wrabetz
(Italy-USA)
Session V:
Organelles alterations in neurodegeneration I
Chairpersons:
Marian di Figlia (USA)
16:00-16:30 J. Paul Taylor (Usa)
"VCP: the Rosetta Stone of Age-Related
Degeneration"
16:30-17:00 Maria Teresa Carri' (Italy)
"Mitochondrial dysfunction in ALS"
17:00-17:30 Coffee
break
Session
VI: Organelles alterations in neurodegeneration II
Chairpersons:
Franco Taroni (Italy), Valerio Magnaghi (Italy)
17:30-18:00
Marian Di Figlia (USA)
"Early dysfunction of recycling endosomes in Huntington's disease"
18:00-18:30
Larry
Wrabetz (Italy)
"Translational homeostasis as a therapeutic target in ER stress diseases"
18:30-19:00 Cecilia Bucci (Italy)
"Molecular basis of Charcot-Marie-Tooth type 2B disease"
19:00-19:20 Late
Breaking News
ŌMutations
in TTC19 cause neurodegeneration in humans and flies associated with impaired
assembly and activity of mitochondrial respiratory chain complex III"
Ghezzi
D, Arzuffi P, Diodato D,
Lamperti C, Zordan M, Costa R, DÕAdamo P, Zeviani M (Italy)
20:30
Social Dinner
Sunday,
May 15, 2011 (morning)
08:30-09:30 Selected
Oral Presentations
Chairpersons:
Maria Teresa Carri' (Italy), Maria Pennuto (Italy)
OC-13
"Function of the zinc finger protein ZPR1 in neurodegeneration associated
with spinal muscular atrophy"
Ahmad
S, Wang Y, and Gangwani L (USA)
OC-14
"PTEN signalling in motor neuron disease (ALS & SMA)"
Ning
K, Drepper C, Valori CV, Wyles M, Ismail A, Higginbottom A, Herrmann T,
Pamela Shaw PJ, Michael Sendtner M
and, Azzouz A (UK)
OC-15
"Oxidatively modified wtSOD1 acquires mutSOD1 like toxic properties and
induces mitochondrial degeneration in sporadic patients lymphoblasts"
Guareschi
S, Cova E, Cereda C, Ceroni M, Bosco D, Trotti D, Pasinelli P (USA)
OC-16
"TDP-43 post-transcriptionally regulates VEGF and PGRN genes by binding to
their 3'UTR sequences"
Colombrita
C, Onesto E, Buratti E, Pizzuti A, Silani V, Baralle FE, and Ratti A
(Italy)
Session VII: Epigenetics and gene
regulation diseases (Role of microRNAs in the neuronal functions and
dysfunctions) I
Chairpersons:
Paola Riva (Italy), Antonia Ratti (Italy)
09:30-10:00
Albert La Spada (USA)
"CTCF regulates ataxin-7 expression
through promotion of a convergently transcribed, antisense non-coding RNA"
10:00-10:30 Noel
Buckley (UK)
"Coordinate
regulation of the transcriptome and epigenome by REST"
10:30-11:00 coffee break
Session VIII: Epigenetics and gene
regulation diseases (Role of microRNAs in the neuronal functions and
dysfunctions) II
Chairpersons:
Paola Riva (Italy), Antonia Ratti (Italy)
11:00-11:30 Peng
Jin (USA)
"Noncoding RNAs in Neurodegenerative
Disorders"
11:30-12:00 Ernest Fraenkel (USA)
"Integrating
multiple 'omic strategies to identify early changes in
Huntington's disease"
12:00-12:30
Udai
Bhan Pandey (USA)
"Genetic interaction between FUS and
TDP-43 influences the neurodegenerative phenotype in a drosophila model of ALS"
12:30-13:30 Lunch
Sunday,
May 15, 2011 (afternoon)
13:30-15:00 Poster
Session B (P-B.01 / P-B.47)
Session VI: Pharmacological
perspectives in neurodegenerative diseases
Chairpersons:
Elena Cattaneo (Italy), Neil Aronin (USA)
15:00-15:30 Brent Stockwell (USA)
"Probing
Cell Death with Small Molecules"
15:30-16:00 Andrea Caricasole (Italy)
"Knocking-down
the druggable genome for HD target discovery"
16:00-16:30 Paolo Paganetti (Switzerland)
"Small molecule inhibitors of
beta-amyloid oligomer toxicity"
16:00-17:00
Bernhard
Landwehrmeyer (Germany)
" Clinical
trials in HD: an update and a perspective"
17:20 Closing
Remarks
______________________
POSTERS
______________________
POSTER
SESSION - A
Saturday, May 14, 2011
(Afternoon)
13:30-15:00 Poster
Session A
P-A.1 / GENE EXPRESSION CHANGES IN
THE BLOOD OF THE R6/2 MOUSE MODEL OF HUNTINGTON'S DISEASE
Diamanti
Daniela, Tarditi Alessia, Magnoni Letizia, Mori Elisa, Malusa Federico,
Fondelli Costanza, Incarnato Danny, Giuseppe Pollio and Caricasole Andrea
(Italy)
P-A.2 / A C. ELEGANS MODEL OF
SPINAL MUSCULAR ATROPHY NEURODEGENERATION
Gallotta
I, Bazzicalupo P, and Di Schiavi E (Italy)
P-A.3 / ATXN8 -62 G/A PROMOTER
POLYMORPHISM AND RISK OF TAIWANESE PARKINSON'S DISEASE
Guey-Jen
Lee-Chen*, Siou-Jia Yang, I-Cheng Chen, Yih-Ru Wu, and Chiung-Mei Chen (Taiwan)
P-A.4 / THE NEED FOR HUNTINGTIN
Alan
Tartakoff* and Purnima Jaiswal (USA)
P-A.5 / ATP13A2 VARIABILITY IN
TAIWANESE PARKINSON'S DISEASE
Chih-Hsin
Lin*, Yih-Ru Wu, Chiung-Mei Chen, Hsueh-Fen Juan, and Guey-Jen Lee-Chen (Taiwan)
P-A.6 / THE ROLE OF RNA BINDING IN
TDP-43 MEDIATED DISEASE
Freibaum
BD*, Taylor JP (USA)
P-A.7 / CLINICAL HETEROGENEITY IN
ITALIAN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS
Piacentini
S*, Piaceri I, Nacmias B, Bagnoli S, Tedde A, Del Mastio M, Paganini M,
Latorraca S, Sorbi S. (Italy)
P-A.8 / AMYLOID BETA ACCUMULATION
IN THE MCGILL-R-THY1-APP RAT MODEL OF ALZHEIMER'S DISEASE
Canneva
F, Melis T, Leon WC, Dobner J, Ducatenzeiler A, Schilling S, vonHrsten S and Cuello AC (Canada, Germany)
P-A.9 / NEUREGULIN 1 TYPE III CAN
RESTORE MYELIN THICKNESS IN P0Q215X CONGENITAL HYPOMYELINATION MICE
Ornaghi
F, Saccucci S, Schwab M, Nave KA, Feltri ML, Wrabetz L (Italy)
P-A.10 / F1 AND F2 GENERATIONS OF
TRANSGENIC MINIATURE PIG EXPRESSING THE N-TERMINAL TRUNCATED MUTANT HUMAN
HUNTINGTIN
Baxa
M (1*), Hruska-Plochan M, Juhas S, Vodicka P, Pavlok A, Juhasova J, Solc P,
Klima J, Marsala S, Miyanohara A, Weiss A, Vrtel R, Kubickova S, Musilova P,
Cattaneo E, DiFiglia M, Marsala M
and Motlik J (Czech
Republic)
P-A.11 / CEREBELLAR ABNORMALITY
AND PROGRESSIVE NEUROLOGICAL PATHOLOGY IN MICE CONDITIONAL MUTANT FOR THE SOX2
TRANSCRIPTION FACTOR GENE
Baseggio
E, Scherini S, Verzeroli C, Ferri A
Favaro R, De Biasi S and
Nicolis SK (Italy)
P-A.12 / GABA RECEPTORS IN
SCHWANN-LIKE ADULT STEM CELLS: A POSSIBLE TOOL TO IMPROVE NERVE REGENERATION?
Faroni
A, Terenghi G, Magnaghi V (UK)
P-A.13 / GENERATION OF A SERIE OF
KNOCK-IN MOUSE NS (NEURAL STEM) LINES AS A TOOL FOR THE SCREENING OF MOLECULES
USEFUL IN HD
Camnasio
S *, Conforti P, Mutti C, MacDonald M
and Cattaneo E (Italy)
P-A.14 / THE NEUROACTIVE STEROID
ALLOPREGNANOLONE UP-REGULATES EAAC1-MEDIATED GLUTAMATE UPTAKE IN SCHWANN CELLS:
A NEUROPROTECTIVE MECHANISM?
Perego
C*, Di Cairano ES, Fino E, Ballabio M, Magnaghi V (Italy)
P-A.15 / ZEBRAFISH AS A POWERFUL
TOOL TO STUDY HUNTINGTIN'S FUNCTION AND DOMAINS
Gaudenzi
G*, Zuccato C*, Strippoli L, Pistocchi A, Bassi I, Molinari E, Giunta M,
Cotelli F, Cattaneo E (Italy).
P-A.16 / HD MOUSE-IPS
RECAPITULATES SOME FEATURES OF HUNTINGTON'S DISEASE
Castiglioni
V., Onorati M.,Rochon C. and
Cattaneo E. (Italy).
P-A.17 / LT-HESNS CELLS FOR HUMAN
DEVELOPMENTAL STUDIES AND DISEASE MODELING: GENERATION, CHARACTERIZATION, AND
DIFFERENTIATION TO DARPP32+ NEURONS
Andrea
Faedo, Stefano Camnasio, Alessia Delli Carri, Valentina Castiglioni, Marco
Onorati, Stefano Di Donato, Caterina Mariotti, Outi Hovatta, Marisa Jaconi,
Anis Feki, Elena Cattaneo (Italy).
P-A.18 / EXTRINSIC SIGNALS DRIVE
HUMAN EMBRYONIC STEM CELLS DIFFERENTIATION TOWARDS FULLY FUNCTIONAL STRIATAL
DARPP32+ NEURONS
Delli
Carri A, Onorati M, Castiglioni V, Faedo A, Spaiardi P, Biella G, and Cattaneo
E (Italy).
P-A.19 / EZ LAYER: A SELF-RENEWING
AND LONG-TERM EXPANDABLE HUMAN STEM CELL SYSTEM WITH WIDE MULTILINEAGE
NEUROPOTENCY
Onorati
M, Gravati M, Biella G, Svendsen C, Cattaneo E (Italy).
P-A.20 / NF-KB/RELA SPECIFIC
ACETYLATION AND NEURONAL INJURY DURING ISCHEMIA: A POSSIBLE LINK BETWEEN RELA
ACTIVATION AND IRON TRANSPORT IN ISCHEMIA-ASSOCIATED NEURODEGENERATION.
Rosaria
Ingrassia, Ilenia Sarnico1, Anna Lanzillotta, Laura Borgese,Laura Depero, Pier
Franco Spano and Marina Pizzi (Italy).
P-A.21 / THE
POLYGLUTAMINE-EXPANDED MUTANT HUNTINGTIN SELECTIVELY ACTIVATES THE
AMP-ACTIVATED PROTEIN KINASE IN STRIATAL NEURONS OF HUNTINGTON'S DISEASE
Ju
T-C and Chern Y (Taiwan)
P-A.22 / DJ-1 KNOCK-DOWN IMPAIRS
ASTROCYTES MITOCHONDRIAL FUNCTION
Giulia
Ambrosi*, Niccole J. Larsen, Steven J. Mullett, Sarah B. Berman, David A.
Hinkle (Italy)
P-A.23 / 5-S-CYSTEINYLDOPAMINE
AFFECTS THE ESPRESSION OF ALPHA-SYNUCLEIN AND OF THE THIOL OXIDOREDUCTASE ERp57
Mosca
L*, Aureli C, Masci A, Francioso A, Faraldi M, Gaetani S, Ferraro A, DÕErme M,
Cassano T (Italy).
P-A.24 / PANK2 SILENCING CAUSES
GENERAL CELL GROWTH REDUCTION AND A CELL SPECIFIC FERROPORTIN UPREGULATION.
Dario
Finazzi*, Maura.Poli, Sara Luscieti, Maura Derosas, Roberto Dominici,
Alessandro Campanella,Paolo Arosio (Italy).
P-A.25 / A NEW INTEGRATED
BIOCHEMICAL APPROACH SHOWS A DECREASE OF OXIDATIVE STRESS IN IDEBENONE-TREATED
FRDA PATIENTS AFTER ORAL TOCOTRIENOL SUPPLEMENTATION
Marini
M, Pini A, Abruzzo PM, Malisardi G, Marchionni C, Modesti A, Gamberi T,
Morganti E, Ferreri C, Vertuani S, Fortuna F, Ghezzo A, Manfredini S (Italy).
P-A.26 / INSULIN AND IGF-1
PRECLUDE OXIDATIVE STRESS IN HUNTINGTONÕS DISEASE KNOCK-IN STRIATAL CELLS
Rosenstock
TR *, Ribeiro M, Oliveira CR, Rego AC
(Portugal)
P-A.27 / DEVELOPING CENTRAL
NERVOUS SYSTEM AND VULNERABILITY TO PLATINUM COMPOUNDS: MOLECULAR MARKERS OF
CELL PROLIFERATION AND DEATH, AND CELL DIFFERENTIATION
*Piccolini
VM, *Dal Bo V, De Pascali S, Migoni D, Fanizzi PF, Barni S, Bottone MG,
Fenoglio C (3, 4), Bernocchi G (Italy).
P-A.28 / PARP ACTIVATION MODULATES
APOPTOSIS EVENTS IN CELLULAR AND ANIMAL MODELS OF ALZHEIMER DISEASE
Mosca
L, Martire S, Fuso A, Beyaie D, Masci A, Rotili D, De Leo A Consalvi V, Giordano C, Scarpa S, dÕErme
M (Italy).
P-A.29 / LYSOZYME INTERACTION WITH
NEGATIVELY CHARGED LIPOSOMES RESULTS IN PROTEIN AGGREGATION AND VESICLE FUSION
Russo
E*, Al Kayal T, Nappini S, Berti D, Bucciantini M, Berti D, Stefani M, Baglioni
P (Italy).
P-A.30 / AXON PATHOLOGY IN MOUSE
MODELS OF HUNTINGTON'S DISEASE
Martina
Marangoni, Robert Adalbert, Lucie Janeckova, ^Michael Coleman and ^Laura
Conforti (UK)
^equal
contribution
P-A.31 / A NH2 TAU FRAGMENT
TARGETS AND IMPAIRS NEURONAL MITOCHONDRIA AT AD SYNAPSES
G. Amadoro*, V. Corsetti*,
F.Florenzano, R.Bussani, D. Mercanti, P. Calissano (Italy).
*
These authors equally contribute to this work
P-A.32 / PROTEIN AGGREGATION IS
PREDICITVE OF A FASTER DISEASE PROGRESSION IN MOUSE MODELS OF AMYOTROPHIC
LATERAL SCLEROSIS.
Marino
M*, Papa S, Peviani M, Cheroni C, Ferraiuolo L, Shaw P, Fontana E, DeBiasi S,
Bendotti C (Italy).
P-A.33 / CURCUMIN AND CEFTRIAXONE:
TWO DIFFERENT MOLECULES INDUCING COMMON NEUROPROTECTIVE EFFECTS IN AN IN VITRO
MODEL OF ALEXANDER DISEASE
Bachetti
T*, Di Zanni E, Balbi P, Sechi GP, Ceccherini I (Italy).
P-A.34 / TRANSCRIPTIONAL CONTROL OF THE SMALL HEAT SHOCK PROTEIN B8
(HSPB8) IN MOTORNEURONS
Crippa
V*, Boncoraglio A, Rusmini P, Sau D, Giorgetti E, and Poletti A (Italy)
P-A.35 / INTRASTRIATAL VIRAL
VECTOR DELIVERY OF MUTANT HUNTINGTIN AS RAT MODEL OF HUNTINGTON'S DISEASE.
Ceccarelli
I, Scali C, Rossini L, Pollio G, Biotti I, Cappelli A, Miragliotta V, Fiengo P,
Caricasole A and Gaviraghi G. (Italy).
P-A.36 / PERIPHERAL GANGLION
NEURONS FROM HUMAN MUTANT P301S TAU TRASNGENIC MICE TO INVESTIGATE TAU
PATHOLOGY
Mellone
M*, Andrews MR, Dassie E, Richardson JC, Tolkovsky AM, Goedert M, and
Spillantini MG (UK)
P-A.37 / HUMAN STEM CELL-DERIVED
NEURONS AS A MODEL TO STUDY TAU FUNCTION AND DYSFUNCTION
Mariangela
Iovino,Rickie Patani, Siddharthan Chandran, and Maria Grazia Spillantini (UK)
P-A.38 / FORMATION AND DEGRADATION
OF ER MEMBRANE-DERIVED CYTOPLASMIC INCLUSIONS GENERATED BY THE AMYOTROPHIC
LATERAL SCLEROSIS-ASSOCIATED MUTANT FORM OF VAPB
Papiani
G *, Ruggiano A, Fossati M, Fasana E, Francolini M, Borgese N, and Navone F (Italy).
P-A.39 / A NOVEL MAPT MUTATION
ASSOCIATED TO LATE-ONSET SPINAL MUSCULAR ATROPHY WITHOUT DEMENTIA IN A LARGE
ITALIAN FAMILY
Ronchi
D (1,3,*), Di Fonzo A, Gallia F, Fassone E, Donadoni C, Salani S, Bordoni A,
Rizzuti M, Del Bo R, Corti S, Sacilotto G, Nobile-Orazio E, and Comi GP (Italy).
P-A.40 / PRP90-231 INTRACELLULAR
AGGREGATION INDUCES CELL DEATH THROUGH LYSOSOMAL LOSS OF IMPERMEABILITY
Thellung
S *, Corsaro A, Villa V, Vella S, Pagano A and Florio T (Italy).
P-A.41 / STRUCTURAL BASIS FOR
CHAPERONIN-MEDIATED INHIBITION OF PROTEIN AGGREGATION IN HUNTINGTONÕS DISEASE
REVEALED BY CRYO-ELECTRON TOMOGRAPHY
Shahmoradian
SH*, Galaz JG*, Cong Y, Chen BY, Schmid MF, Frydman J, Ludtke SJ, Chiu W (USA).
*Both
authors contributed equally to this work.
P-A.42 / MITOCHONDRIAL FUNCTION OF
JNK ISOFORMS DURING STATUS EPILEPTICUS-INDUCED NEURONAL DAMAGE
Spigolon
G, Zhao Y, Bonny C, Herdegen T, Vercelli A (Italy).
P-A.43 / MUSCLE CELLS AND MOTONEURONS
DIFFERENTIALLY REMOVE MUTANT SOD1 IN TWO CELL MODELS OF AMYOTROPHYC LATERAL
SCLEROSIS.
Onesto
E (*), Rusmini P, Crippa V, Ferri N, Zito A, Galbiati M, Poletti A (Italy).
P-A.44 / PARKIN ABSENCE IMPACTS
MICROTUBULE STABILITY AND AXONAL TRANSPORT IN KNOCKOUT MICE.
Cartelli
D, Sassone J, Amadeo A, Ciammola A, And Cappelletti G (*) (Italy).
P-A.45 / A MAJOR ROLE FOR
SIDE-CHAIN POLYGLUTAMINE HYDROGEN BONDING IN IRREVERSIBLE ATAXIN-3 AGGREGATION.
Natalello
A, Frana AM, Relini A, Apicella A, Invernizzi G, Casari C, Gliozzi A, Doglia
SM, Tortora P* , Regonesi ME (Italy).
P-A.46 / THE ROLE OF THE
MITOCHONDRIAL m-AAA PROTEASE COMPLEX IN THE PATHOGENESIS OF HEREDITARY
SPINOCEREBELLAR DEGENERATIONS
Di
Bella D*, Fracasso V, Magri S, Lazzaro F, Plumari M, Mariotti C, Gellera C,
Muzi-Falconi M, Taroni F (Italy)
P-A.47 / DROSOPHILA MODEL OF
TDP-43 NEUROPATHY
Rebecca
B. Smith*, J. Paul Taylor (USA)
P-A.48 / CHOLESTEROL LOADED NANOPARTICLES
INJECTED SYSTEMICALLY REACH THE BRAIN AND LOCALIZE INTO SPECIFIC CELL TYPES
Valenza
M*, Tosi G, Cepeda C, Bondioli L, Brilli E, Ruozi B, Joshi PR, Chen JY, Singh
S, Vandelli MA, Levine MS, Cattaneo E (Italy)
______________________
POSTER
SESSION - B
Sunday, May 15, 2011
(Afternoon)
13:30-15:00 Poster
Session B
P-B.1 / A PROLONGED
PHARMACOLOGICAL BLOCKADE OF TYPE-5 METABOTROPIC GLUTAMATE RECEPTORS PROTECTS
CULTURED SPINAL CORD MOTOR NEURONS AGAINST EXCITOTOXIC DEATH
Simona
D'Antoni, Antonio Berretta, Giovanna Seminara, Patrizia Longone, Anna Maria
Giuffrida-Stella, Giuseppe Battaglia, Maria A. Sortino, Ferdinando Nicoletti,
Maria V. Catania* (Italy).
P-B.2 / A NOVEL APPROACH TO THE
STUDY OF DEGENERATION IN THE NEUROMUSCULAR JUNCTION (NMJ)
Simone
D., Colosimo A (Italy)
P-B.3 / SCA14 MUTATIONS AFFECT THE
INTRA-MOLECULAR CLAMP BETWEEN THE C1 DOMAIN AND CARBOXYL-TERMINUS OF PKC-GAMMA
Jezierska
J *, Goedhart J, Westerink JT, Reits EA
and Verbeek DS (The
Netherlands).
P-B.4 / INTRINSIC BRAIN
INFLAMMATION AND ENHANCED SUSCEPTIBILITY TO KAINATE-INDUCED SEIZURES IN A TRANSGENIC
MOUSE MODEL OF INHERITED CREUTZFELDT-JAKOB DISEASE
Bertani
I, Maroso M, Mantovani S, Iori V, Vezzani A, Chiesa R (Italy).
P-B.5 / ALTERATION OF SECRETORY
PROTEIN TRAFFICKING AS POSSIBLE PATHOGENETIC MECHANISM IN INHERITED PRION
DISEASES
Restelli
E *, Mantovani S, and Chiesa R (Italy).
P-B.6 / GENERATION OF A TRANSGENIC
MOUSE MODEL OF FATAL FAMILIAL INSOMNIA
Mantovani
S*, Bertani I, Bianchi S, Del Gallo F, Mangieri M, Tagliavini F, Forloni G,
Imeri L and Chiesa R (Italy).
P-B.7 / CELLULAR MODELS TO
INVESTIGATE THE PATHOGENIC MECHANISMS OF CEREBRAL AMYLOIDOSIS ASSOCIATED WITH
NONSENSE MUTATIONS OF THE PRION PROTEIN
Pozzoli
M *, Bertani I and Chiesa R
(Italy).
P-B.8 / ZINC MODULATES COPPER
COORDINATION MODE IN PRION PROTEIN OCTA-REPEAT SUBDOMAINS
Francesco
Stellato, Ann Spevacek, Olivier Proux, Velia Minicozzi, Glenn Millhauser,
Silvia Morante (Italy).
P-B.9 / PERIPHERAL MARKERS OF
NEUROINFLAMMATION IN PARKINSON'S DISEASE
Bazzini
E *, Armentero MT, Cerri S, Levandis G, Ghezzi C, Pacchetti C, Cristina
STassorelli C,Zangaglia R, Blandini F (Italy).
P-B.10 / NEW INSIGHTS INTO THE
ROLE OF HSP90 IN HUNTINGTON'S DISEASE: INFLUENCE ON PROTEIN CLEARANCE AND
STABILITY
Barbara
Baldo*, Andreas Weiss, Christian Parker, Jens Richter, Gabi Schutzius, Paolo
Paganetti and Klemens Kaupmann (Switzerland).
P-B.11 / ALTERATED AXONUCLEAR
COMMUNICATION IN MOTONEURONS OF RODENT MODELS OF FAMILIAL AMYOTROPHIC LATERALE
SCLEROSIS:ROLE OF IMPORTIN BETA AND VIMENTIN.
Peviani
M, Spano G and Bendotti C (Italy).
P-B.12 / ASSESSMENT OF
CHAPERONE-MEDIATED AUTOPHAGY IN CIRCULATING LYMPHOMONOCYTES OF PATIENTS WITH
PARKINSON'S DISEASE
Sala
G *, Stefanoni G, Arosio A, Melchionda L, Saracchi E, Fermi S, Brighina L,
Ferrarese C (Italy).
P-B.13 / VASCULAR INFLAMMATION AND
LEUKOCYTE TRAFFICKING IN AN EXPERIMENTAL MODEL OF ALZHEIMER'S DISEASE
Zenaro
E*, Budui S, Pietronigro E, Della Bianca V, Rossi B, Angiari S, Losso E,
Donnarumma T, Constantin G (Italy).
P-B.14 / HUMAN INDUCED PLURIPOTENT
STEM CELLS FROM PARKINSON'S DISEASE AFFECTED PATIENTS
Ungaro,
F*, Maffioletti S, Dell'Anno MT, Broccoli V (Italy).
P-B.15 / ACETYLATION OF NF-KAPPA B
P50/RELA IN THE EPIGENETIC REGULATION OF TRANSCRIPTION: A NEUROPROTECTIVE
TARGET IN BRAIN ISCHEMIA
Lanzillotta
A *, Sarnico I, Ingrassia R, Boroni F, Branca C, Benarese M, Faraco G, Blasi F,
Chiarugi A, Spano PF, Pizzi M (Italy).
P-B.16 / TARGETING NF-KAPPAB AND
EPIGENETIC CHROMATIN REMODELLING IN THE THERAPY OF POST-ISCHEMIC BRAIN INJURY
C.
Branca *, A. Lanzillotta, I. Sarnico, M. Benarese, G. Pignataro, O. Cuomo, L.
Annunziato, G. Faraco, F. Blasi, A. Chiarugi, PF. Spano, M. Pizzi (Italy).
P-B.17 / LYSOSOMAL GLYCOHYDROLASES
ARE ASSOCIATED TO LIPID RAFTS OF MOUSE BRAIN: POTENTIAL IMPLICATION FOR
NEURODEGENERATION
Magini
A*, Polchi A, Tancini B, Urbanelli L, Tozzi A, Tantucci M, Calabresi P and Emiliani C (Italy).
P-B.18 / NOVEL DYSFUNCTIONS AT THE
ORIGIN OF HYPOMYELINATION, A FEATURE OF NIEMANN PICK DISEASE TYPE A
Buccinn
B*, Lomartire A Ramondetti C, De
Marco G, Rinaudo MT, Lupino E, Piccinini M (Italy).
P-B.19 / ATAXIN-2 DEFICIENCY
CAUSES CHANGES IN THE EXPRESSION OF GRB2 AND SRC
Drost
J*, Nonis D, Damrath E, Auburger G (Germany).
P-B.20 / NEUROPROTECTIVE EFFECT OF
NOVEL HDAC INHIBITORS ON SCA3 CELLS
Chen
HJ, Yen HH, Wang HH, Hsieh HM (Taiwan).
P-B.21 / EXPRESSION OF PHOX2B
TARGET GENES IN THE CONGENITAL CENTRAL HYPOVENTILATION SYNDROME (CCHS)
Di
Lascio S*, Benfante R, Bachetti T, Ceccherini I and Fornasari D (Italy).
P-B.22 / THE C-TERMINUS OF P/Q
TYPE VOLTAGE GATED CALCIUM CHANNEL (CAV2.1) ALPHA1A SUBUNIT MODULATES THE
TRANSCRIPTION OF OTHER NEURONAL GENES.
Veneziano
L. *, Mantuano E., Maresca G., Arisi I., Brandi R., DÕOnofrio M., Imbrici P.,
Frontali M., Felsani A. (Italy).
P-B.23 / NEURONAL LSD1, AN
EPIGENETIC ENZYME DEVOTED TO NEURONS
Paganini
L, Toffolo E, Zibetti C, Rusconi F, Romanelli L, Tedeschi G, Sala C, and
Battaglioli E (Italy).
P-B.24 / AN IMMUNOHISTOCHEMICAL
ANALYSYS OF HUNTINGTIN AND REST EXPRESSION IN HUMAN CONTROL AND HD BRAIN
Caldera
V, Schiffer D, Mellai M, Zuccato C, Cattaneo E (Italy).
P-B.25 / miR-103 AND miR-107 ARE
INVOLVED IN CDK5R1 EXPRESSION MODULATION: POSSIBLE IMPLICATIONS IN ALZHEIMER'S
DISEASE
Moncini
S, Salvi A, Zuccotti P*, Viero G, Quattorne A, De Petro G, Barlati S, Venturin
M, Riva P (Italy).
P-B.26 / ERK MODULATION IN
FIBROBLASTS FROM ALZHEIMER'S DISEASE PATIENTS: INVOLVEMENT IN APP METABOLISM
AND EAAT1 PROCESSING
Zoia
CP, Compagnoni P, Cereda D, Isella V, Tremolizzo L and Ferrarese C (Italy).
P-B.27 / DOWNNREGULATION OF THE
CHROMATIN-REMODELLING FACTOR BRAHMA IN SOD1 G93A CELLS MODIFIES TRANSCRIPTION
AND ALTERNATIVE SPLICING OF NRG1 AND P15RS, TWO GENES INVOLVED IN AXON GROWTH
AND GUIDANCE
Fontana
G.A., Rigamonti A., Lenzken S.C.and Barabino S (Italy).
P-B.28 / PROTEIN KINASE A
ATTENUATES THE TOXICITY OF POLYGLUTAMINE ANDROGEN RECEPTOR
Scaramuzzino
C, Parodi S, Sambataro F, Contestabile A, Gozes I, Pennuto M (Italy).
P-B.29 / NEUROPROTECTIVE POTENTIAL
OF ADENOSINE A2A AND CANNABINOID CB1 RECEPTOR ANTAGONISTS IN AN ANIMAL MODEL OF
PARKINSON'S DISEASE
Cerri
S*, Levandis G, Ambrosi G, MÄller CE, Blandini F, and Armentero MT (Italy).
P-B.30 / STUDY OF PI3/AKT PATHWAY
IN A HUMAN NEUROBLASTOMA CELL LINE AFTER PHARMACOLOGICAL TREATMENTS
Ghezzi
C*, Oda A, Blandini F, Armentero MT (Italy).
P-B.31 / PLASMA CYSTATIN C AND
RISK OF DEVELOPING ALZHEIMER'S DISEASE IN SUBJECTS WITH MILD COGNITIVE
IMPAIRMENT
Stoppani
E *, Benussi L, Paterlini A, Glionna M, Albertini V, Levy E, Emanuele E,
Binetti G, Ghidoni R (Italy).
P-B.32 / DETERMINATION OF
BETA-AMYLOID PEPTIDE SIGNATURES IN CEREBROSPINAL FLUID OF FAMILIAL ALZHEIMER
DISEASE MUTATED PATIENTS
Albertini
V *, Stoppani E, Paterlini A, Benussi L, Squitti R, Bruno A, Bernardini S,
Cassetta E, Rossini PM, Squitieri F, Binetti G, Ghidoni R (Italy).
P-B.33 / FISHING FOR A MECHANISM: ZEBRAFISH
AS A MODEL FOR THE STUDY OF MITOFUSIN 2 MUTATIONS CAUSING CHARCOT-MARIE-TOOTH
TYPE 2A
Bergamin
G*, Vettori A, Moro E, Vazza G, Polo G, Tiso N, Argenton F, Mostacciuolo ML
(Italy)
P-B.34 / TFPI IS A USEFUL
BIOMARKER LINKING ENDOTHELIAL PERTURBATION TO NEURODEGENERATION AND
ANTI-Abeta42 ANTIBODIES IN AD PATIENTS
Fabrizio
Piazza*, Daniela Galimberti, Gloria Galimberti, Elisa Conti, Simona Andreoni,
Elio Scarpini, Guido Cavaletti and
Carlo Ferrarese (Italy).
P-B.35 / NEUROPROTECTION IN SPINAL
MUSCULAR ATROPHY (SMA) USING NEURAL STEM CELLS AS A THERAPEUTIC APPROACH
Falcone
M, Rizzo F, Nizzardo M, Simone C, Ronchi D, Donadoni C, Salani S, Ulzi G,
Riboldi G, Bresolin N and Corti S (Italy).
P-B.36 / IDENTIFICATION OF SMALL
MOLECULES INHIBITORS OF THE REST/NRSF COMPLEX AS A POSSIBLE THERAPY FOR
HUNTINGTON'S DISEASE
Ieraci
A, Conforti P, Mutti C, Stefano Camnasio S, Zuccato C, Contini A and Cattaneo E (Italy).
P-B.37 / INCREASED CYTOPLASMIC
MISLOCALIZATION OF TAR DNA BINDING PROTEIN 43 (TDP-43) IN CIRCULATING
LYMPHOMONOCYTES OF ALS PATIENTS RECAPITULATES THE MAJOR DYSFUNCTION FEATURING
MOTOR NEURONS IN THE DISEASE
*De
Marco G, Lupino E, Grifoni S, Calvo A, Moglia C, Buccinn B, Ramondetti C,
Lomartire A, Piccinini M, Rinaudo MT, Giordana MT, Chi A (Italy).
P-B.38 / PC12 CELL GROWN ON
NANOSTRUCTURED TITANIUM OXIDE
E.
Maffioli*, S.Nonnis, S.Forti, N.Cuevas Polo, A. Negri, L.Cannizzaro, C.Lenardi,
P.Milani, G.Tedeschi (Italy).
P-B.39 / ENDOGENOUS IMMUNE RESPONSE
AGAINST ABETA PEPTIDE: INFLUENCE OF ACHETYL-CHOLINESTERASE INHIBITORS
Conti
E, Tironi M, Galimberti G, Zoia CP, Tremolizzo L and Ferrarese C (Italy).
P-B.40 / EX VIVO VISUALIZATION OF
TRANSFECTED HUMAN MESENCHYMAL STEM CELLS AFTER TRANSPLANTATION: A RELIABLE
CELL-LABELING PROTOCOL
Diana
V. *, Cova L., Libani I.V., Ottobrini L., Armentero M-T., Blandini F.,
Lucignani G., Silani V (Italy).
P-B.41 / ASTROCYTES INFLUENCE
CHOLESTEROL-DEPENDENT NEURONAL PROPERTIES IN HUNTINGTONâS DISEASE
Marullo
M*, Valenza M, Cattaneo E (Italy).
P-B.42 / REGULATION OF SOD1 GENE EXPRESSION IN A CELLULAR MODEL OF NEURODEGENERATION.
Milani P, Amadio M, Gagliardi S,
Sardone V, Ghiroldi A*, Cova E, Pascale A, Cereda C (Italy).
P-B.43 / KETOGENIC DIET ACCELERATES THE
ONSET OF DISEASE IN A PLA2G6 KO MOUSE MODEL.
D.
Brunetti, S. Dusi, F. Moda, A. Uggetti, C. Lamperti, Y. Tsujimoto, M. Morbin,
V. Tiranti (Italy)
P-B.44 / MICROTUBULE STABILITY IS
PRECOCIOUSLY AFFECTED IN A MOUSE MODEL OF PARKINSON'S DISEASE.
Cartelli
D(*), Casagrande F, Battaglia G, Busceti C, Molinaro G, Cappelletti G (Italy)
P-B.45 / A NOVEL MUTATION IN SACS GENE
ASSOCIATED TO A COMPLICATED FORM OF HEREDITARY SPASTIC PARAPLEGIA
Gregianin E*, Pegoraro E,
Mostacciuolo ML, Vazza G (Italy).
P-B.46 / TDP-43 SUB-CELLULAR
LOCALIZATION AND KINETICS OF TRANSPORT IN CULTURED CORTICAL NEURONS
Alami
NH*, Taylor JP(USA)
P-B.47 / LIVING CELLS AS DRUG
DELIVERY VEHICLES FOR TREATMENT OF NEURODEGENERATIVE DISORDERS
Batrakova
E*, Haney MJ, Zhao Y, Suresh P, Vetro JA, Klyachko NL, Mosley RL, Kabanov AV,
Gendelman HE (USA)