Molecular and Cellular Basis of Selective Vulnerability




Thursday, July 3rd, 2014 - MORNING

Chairpersons: Roberto Maggi (Italy), Yvan Torrente (Italy)

9.45 Opening - Introduction by the Organizer Roberto Maggi

10:00-10:30 Romina Macco (Italy)

  1. RAC proteins drive migration and differentiation of cortical and hippocampal inhibitory interneurons

10:30-11:00 Valerio Magnaghi (Italy)

  1. Physiology of Schwann cells and myelin formation in peripheral nervous system

11:00-11:30 Elisabetta Vegeto (Italy)

  1. Role of microglia in pathophysiology of the nervous system

11:30-12:00 Yvan Torrente (Italy)

  1. Cortical and spinal motor neurons controlling muscle behavior

12:00 Closing remarks


Molecular and Cellular Basis of Selective Vulnerability

Thursday, July 3rd, 2014 - AFTERNOON

09:00 Registration

13:45 Opening

      Welcome from Prof. Monica Diluca, Pro-Rettore, Universita degli Studi di Milano (Italy)

      Introduction by the Organizers: Caterina Bendotti, Giambattista Bonanno, Angelo Poletti (Italy)

Session I - Motor Neuron Vulnerability

14:00-14:30 George Haase (France)

  1. Motor neuron vulnerability in ALS: lessons from developmental biology

14:30-15:00 Stefania Corti (Italy)

  1. The potential of iPSCs to study spinal muscular atrophy (SMA)

15.00-15:30 Pamela Shaw (UK)

  1. Selective vulnerability of motor neuron in ALS

15.30-16:00 Pico Caroni (Switzerland)

  1. Early mechanisms of motoneurons vulnerability in ALS

16:00-16:30 coffee break

Session II - Motor Neuron interaction with surrounding and target cells

16:30-17:00 Lauren Rosenblum (USA)

  1. Contribution of astrocytes to motor neuron degeneration in ALS

17:00-17:30 Laura Ferraiuolo (USA)

  1. Oligodendrocytes from ALS samples induce motor neuron death

17:30-18:00 Severine Boillee (France)

  1. Contribution of microglial cells and macrophages to motor neuron degeneration in ALS

18:00-18:30 Antonio Musaro' (Italy)

  1. Muscle-motoneuron dialogue in ALS

18:30-19:00 Andrew Lieberman (USA)

  1. Skeletal muscle as a therapeutic target in SBMA

19:00-20:30 Welcome Party

Friday, July 4th, 2014

Session III - Molecular alteration of cells affected in ALS

08:30-09:00 Piera Pasinelli (USA)

  1. NMJ as primary target in ALS: lessons from mutant FUS

09:00-09:30 Giambattista Bonanno (Italy)

  1. Targetting Group I metabotropic glutamate receptors in ALS

09:30-10:00 Chris Miller (UK)

  1. The ER mitochondria axis and ALS

10:00-10:30 Maria Teresa Carri (Italy)

  1. RNA binding proteins in neurodegeneration

10:30-11:00 coffee break

11:00-11:30 Antonia Ratti (Italy)

  1. Functional and dysfunctional RNA metabolism in ALS

11:30-12:00 Serena Carra (Italy)

  1. Inhibition of autophagy, lysosome and VCP function impairs stress granule

12:00-12:30 Valentina Bonetto (Italy)

  1. Cyclophilin A as key protein interactor in the pathomechanism of different ALS

12:30-13:00 Angelo Poletti (Italy)

  1. The differential role of chaperones and the degradative system in motor neuron and muscle cells

13:00-13:00 Caterina Bendotti (Italy)

  1. General discussion and Closing Remarks

Final Program