The JUPITERLAB research in the Department of Pharmaceuticals Sciences – University of Milan is organized around two main research area: Medicinal Chemistry and Chemical Biology.
The various research topics carried out within these themes are ideal for executing interdisciplinary research from a strong multidisciplinary basis.
Beside the up mentioned area JUPITERLAB is deeply involved in the identification of pharmaceutical impurities and in applying analitycal and preparative stereotechnologies to bioactive compound.
Our expertises
Discovery throught drug repositioning, SAR studies and computational aid molecules or compound libraries active on specific biological target(s) and molecular probes.
Medicinal Chemistry
The JUPITERLAB philosophy regarding Medicinal Chemistry is based upon the traditional cycle of design-synthetize-test-analyze. This traditional cycle is boosted by adding a hypothesis-driven optimization process which is based on QSAR interpretation and computer aided techniques provided by VENUS and MARSLABs.
Medicinal Chemistry
Chemical Biology
The JUPITERLAB believes in the motto “develop chemistry to understand biology” we address this mission by asking the right questions and syntethize compounds that answer these questions. For this reason the lab designs and synthetizes new chemical tools to understand and manipulate biological systems. Moreover we develop and optimize probes for investigation of disease relevant mechanism in vitro and in vivo to improve a personalized medicine approach.
For this mission JUPITERLAB collaborates with Professor Tawfik at the Weizmann Institute of Science set in Israel and with Professor Dave Roman from the college of Pharmacy at The Iowa University.
Chemical Biology
Identification of pharmaceutical impurities
The goal of the drug development process is to fully elucidate the chemical structures of unknown pharmaceutical impurities present in either drug substances or drug products above a particular threshold. To identify a pharmaceutical impurities is inherently interdisciplinary since is based either on the knowledge of organic or analytical chemistry, thus we work closely in collaboration with analysts. This mission is underpinned by our expertise in chemical synthesis and structure elucidation by NMR analysis together with the skilled analyst group of Professor Aldini set in the same building.
Identification of pharmaceutical impurities
Analytical and preparative stereotechnologies
The goal of analitycal and preparative stereotechnologies is to resolve and recover as much as possible an enantiomeric pairs. Chirality and chirality preference are intrinsically present in nature thus both medicinal and biological chemists which are both involved in understanding how chemical agents interact with living matter cannot overlook this aspect.
The JUPITERLAB has continuously been interested in this challenge and during the past decades had increased and refined its expertise and know-how in stereotechnologies.
Analytical and preparative stereotechnologies
Research topics
Chemical processes and procedures using sustainable products and green chemistry approaches will be developed whenever if possible.
Jupiterian
The Synthetic & Bioorganic Chemistry Unit is mainly dedicated to hit to lead medicinal chemistry and lead optimization. JUPITERLAB with the Molecular Modelling & Drug Design unit (VENUS and MARSLABs) forms the PHARMACEUTICAL BIOCHEMISTRY GROUP that is engaged in innovative, multidisciplinary and collaborative research programs in order to discover and develop new drugs or small molecules for improving human health and for investigation of diseases’s relevant mechanism.
If you want to become a Jupiterian check the available position page.
Current Master thesis student

Giulia FOGLI
Master Thesis Student

Luciano VISTOLA
Master Thesis Student

Lucrezia SPINELLI
Master Thesis Student

Alessandro RONCORONI
Master Thesis Student
Alumni



Good Luck Angelica!!!
Ready for a new position
Amazing time and challanging days spent together 🙂
Contact us
Principal Investigator of the Unit
– Laura Fumagalli
Via L. Mangiagalli, 25 – 20133 Milan
Office room: 2063
Lab room: 2061
- Office: +39 02 503 19303
- Lab: +39 02 503 19304
- laura.fumagalli@unimi.it
- laura-fumagalli