SEMINARIO MATEMATICO E FISICO DI MILANO
AVVISO DI CONFERENZA
Martedi 14 giugno 2011, alle ore 14:30 presso l’aula seminari 3014 del Dipartimento di Matematica e Applicazioni, Università di Milano Bicocca in Via Cozzi 53
Prof. De Witt Sumners Department of Mathematics Florida State University
terra’ la conferenza
“DNA Topology”
Abstract: This lecture will give an introduction to the topology and geometry of DNA. Cellular DNA is a long, thread-like molecule with remarkably complex topology. Enzymes that manipulate and carefully control the geometry and topology of cellular DNA perform many important cellular processes (including segregation of daughter chromosomes, gene regulation, DNA repair, and generation of antibody diversity). Some enzymes pass DNA through itself via enzyme-bridged transient breaks in the DNA; other enzymes break the DNA apart and reconnect it to different ends. In the topological approach to enzymology, circular DNA is incubated with an enzyme, producing an enzyme signature in the form of DNA knots and links. By observing the changes in DNA geometry (supercoiling) and topology (knotting and linking) due to enzyme action, the enzyme binding and mechanism can often be characterized. This talk is intended for a general scientific audience, and will discuss topological models for DNA strand passage and exchange, including the analysis of topoisomerase experiments on circular DNA using knot theory.
Tutti gli interessati sono invitati a partecipare.
Il Direttore del Seminario Franco Tomarelli
Per ulteriori informazioni sulla attivita’ del seminario: http://www.mate.polimi.it/smf