Professor Daniele Passarella

Curriculum vitae

1986 Degree in Chemistry – University of Milan
1988-1991 PhD – University of Milan
1992 Post-doc under the supervision of Prof. J. Bosch – University of Barcelona
1993 Researcher at the “Department of Chemistry” (University of Milan)
2006 Ass. Prof. of Organic Chemistry, University of Milan – Fac. Sc. Mat Fis. Nat.
2006 Collaborating Prof. Univ. Barcelona
2020 Full Professor of Organic Chemistry – University of Milan – Department of Chemistry

Teaching Activity in the field of Organic Chemistry, Organic Synthesis, Natural Products Chemistry

Research interests: in the field of Organic and Bioorganic Chemistry

Preparation of quality collections of heterocyclic and natural compounds with biological interest
- New scaffolds for inhibitors of TK (cMet, Abl, Src), p53, HDAC, tubulin, sirtuins, topoisomerase I and II, hedgehog pathway
Chemistry of Natural Products: Camptothecin, Podophillotoxin, Thiocolchicine, Colchicine, Evodiamine, Vinca Alkaloids (vincristine, vinblastine), Makaluvamine, Piperidine Alkaloids, Epothilone A
Application of “Flow Chemistry” to “Medicinal Chemistry” and to the Synthesis of Natural Products
Enatioselective synthesis of nitrogen containing compounds
Preparation of hybrid compounds
- Multiple interaction with biological targets involved in the biology of cancer
- Preparation of prodrugs
- Dynamic Combinatorial Libraries
- Self-assembled nanoparticles for cancer treatment
- Hetero self-assembled nanoparticles for treatment of cancer stem cells

Scientific communications, seminars and courses

Coordinators of International projects:

From 2019: Horizon 2020 MSCA-ITN-EJD (TubInTrain) “Tuning Tubulin Dynamics and Interactions to Face Neurotoxicity” – Project n. 860070
MAECI Italia-India Strategic Projects 2017-2019 Title: “Development of bivalent antitubulin compounds” – Role: Italian Coordinator
2007-2011 Chair – COST Action CM 0602 Inhibitors of Angiogenesis: Design, Synthesis and Biological Exploitation
2012-2016 Chair – Cost Action CM 1106 Chemical Approaches to Targenting Drug Resistance in cancer Stem cells

Participation to ongoing Financed Projects:

Telethon: Title: “Neuroserpin misfolding and FENIB neurodegeneration: mechanism and inhibition processes” – Role: Collaborator
AIRC: Title: “Design and development of CDK2 and EGFR type III allosteric inhibitors as anticancer drugs” – Role: Responsible of the Milano UNIMI unit
Prin2017: Title: “Identification, sustainable synthesis and study of molecular drugs efficacy in brain tumors treatment” – Role: Responsible of the Milano UNIMI unit
FRRB: Title: New frontiers of engineered nanovectors to improve treatment efficacy and safety in neurological disorders (Nevermind) – Role: collaborator

Collaborations (synthesis, pharmacological evaluation, isolation of natural products, computational chemistry)