Professor Daniele Passarella

Curriculum vitae

  • 1986 Degree in Chemistry – University of Milan
  • 1988-1991 PhD – University of Milan
  • 1992 Post-doc under the supervision of Prof. J. Bosch – University of Barcelona
  • 1993 Researcher at the “Department of Chemistry” (University of Milan)
  • 2006 Ass. Prof. of Organic Chemistry, University of Milan – Fac. Sc. Mat Fis. Nat.
  • 2006 Collaborating Prof. Univ. Barcelona
  • 2020 Full Professor of Organic Chemistry – University of Milan – Department of Chemistry

Teaching Activity in the field of Organic Chemistry, Organic Synthesis, Natural Products Chemistry

Research interests: in the field of Organic and Bioorganic Chemistry

  • Preparation of quality collections of heterocyclic and natural compounds with biological interest
    • New scaffolds for inhibitors of TK (cMet, Abl, Src), p53, HDAC, tubulin, sirtuins, topoisomerase I and II, hedgehog pathway
  • Chemistry of Natural Products: Camptothecin, Podophillotoxin, Thiocolchicine, Colchicine, Evodiamine, Vinca Alkaloids (vincristine, vinblastine), Makaluvamine, Piperidine Alkaloids, Epothilone A
  • Application of “Flow Chemistry” to “Medicinal Chemistry” and to the Synthesis of Natural Products
  • Enatioselective synthesis of nitrogen containing compounds
  • Preparation of hybrid compounds
    • Multiple interaction with biological targets involved in the biology of cancer
    • Preparation of prodrugs
    • Dynamic Combinatorial Libraries
    • Self-assembled nanoparticles for cancer treatment
    • Hetero self-assembled nanoparticles for treatment of cancer stem cells

Scientific communications, seminars and courses

  • Papers on international journals: 144 (Patents: 1)
  • Conferences: 66

Coordinators of International projects:

  • From 2019: Horizon 2020 MSCA-ITN-EJD (TubInTrain) “Tuning Tubulin Dynamics and Interactions to Face Neurotoxicity” – Project n. 860070
  • MAECI Italia-India Strategic Projects 2017-2019 Title: “Development of bivalent antitubulin compounds” – Role: Italian Coordinator
  • 2007-2011 Chair – COST Action CM 0602 Inhibitors of Angiogenesis: Design, Synthesis and Biological Exploitation
  • 2012-2016 Chair – Cost Action CM 1106 Chemical Approaches to Targenting Drug Resistance in cancer Stem cells

Participation to ongoing Financed Projects:

  • Telethon: Title: “Neuroserpin misfolding and FENIB neurodegeneration: mechanism and inhibition processes” – Role: Collaborator
  • AIRC: Title: “Design and development of CDK2 and EGFR type III allosteric inhibitors as anticancer drugs” – Role: Responsible of the Milano UNIMI unit
  • Prin2017: Title: “Identification, sustainable synthesis and study of molecular drugs efficacy in brain tumors treatment” – Role: Responsible of the Milano UNIMI unit
  • FRRB: Title: New frontiers of engineered nanovectors to improve treatment efficacy and safety in neurological disorders (Nevermind) – Role: collaborator

Collaborations (synthesis, pharmacological evaluation, isolation of natural products, computational chemistry)

  • National and International Research Institutions
  • Pharmaceutical Companies