Prof. Daniele Passarella’s Research Group
Department of Chemistry
University of Milan



of API

Natural Products
as Leads


European Joint Doctorate on chemistry and biology of neurodegeneration, Horizon 2020 – Marie Skłodowska-Curie Innovative Training Networks

It is a plesure for us to introduce you the new European Joint Doctorate called TubInTrain. You can find more details on this ufficial Link.

Follow the project on social

Cyrene: A Green Solvent for the Synthesis of Bioactive Molecules and Functional Biomaterials

Int. J. Mol. Sci., 2022

Discover our latest review on a cyrene, a promising green chemistry solvent! To know more follow the link.

Discovery of a Novel Trifluoromethyl Diazirine Inhibitor of SARS-CoV-2 Mpro

We have found a novel inhibitor of SARS-CoV-2 Mpro based on a trifluoromethyl diazirine. To find out more details follow the Link

Total Synthesis of (−)-Cannabidiol-C4

Dedicated to Professor Cesare Gennari on the occasion of his 70th birthday.

We have just published the total synthesis of CBD-C4 (cannabidibutol),  a natural product that is present in the extracts of Cannabis.

Our PhD students performed its enantioselective synthesis using the a) 3,5-dimetoxybenzaldehyde as starting material, b) Corey-Bakshi-Shibata reduction, c) Claisen-Ireland rearrangement, d) ring-closing metathesis, and e) not-trivial demethylation induced by sodium ethanethiolate. To find out more details follow the Link


New frontiers of engineered nanovectors to improve treatment efficacy and safety in neurological disorders.

On January 21st, Kick-off meeting of Nevermind
“New frontiers of engineered nanovectors to improve treatment efficacy and safety in neurological disorders”

Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics

Chem. Eur. J., 2022
Great work from Zlata and the rest of the team on maytansinol! It was also selected as Front Cover! More about it at this Link

Folic acid functionalization for targeting self-assembled paclitaxel-based nanoparticles

RCS Advances, 2022

Our recent work on hetero-nanoparticles self-assembled from a conjugate bearing folic acid as the targeting agent, and another bearing paclitaxel as the active agent. Find out more under the Link

Stereoselective Synthetic Strategies to (−)-Cannabidiol

ChemistrySelect, 2022

To learn about the challenges in the stereoselective synthesis of (−)-cannabidiol and the ways to overcome them, check our new review! Link

Notice Board

Publications of the research group

Save the date!

Upcoming webinars, seminars, conferences etc.

  • The XLVII edition of the “Attilio Corbella” International Summer School on Organic Synthesis (ISOS 2023) will take place in Gargnano (BS, Italy) from 16th to 22nd June 2023.

  • The International Summer School on Natural Products (ISSNP 2023) will take place on the 2nd-7th July 2023 Maratea, Italy.

Browse the News

challenging papers, breaking news, images and videos

The major genetic risk factor for severe COVID-19 is inherited from Neanderthals, Hugo Zeberg & Svante Pääbo, Nature, Nov 2020.
Anthony Fauci and Alberto Mantovani Webinar
Carlo Rovelli: Seminar about his new book “Helgoland”.
SARS-CoV-2 vaccines in development Nature paper
COVID-19: Drug Targets and Potential TreatmentsJournal of Medicinal Chemistry – Paper
COVID research updates
Nature wades through the literature on the new coronavirus — and summarizes key papers as they appear
Coronavirus: Research, Commentary, and News
The Science journals are striving to provide the best and most timely research, analysis, and news coverage of COVID-19
Food an Drug Administration
Agenzia Italiana del Farmaco – Vaccini COVID-19

Professor Daniele Passarella

Full Professor of Organic Chemistry
University of Milan – Department of Chemistry