Prof. Daniele Passarella’s Research Group
Department of Chemistry
University of Milan



of API

Natural Products
as Leads


European Joint Doctorate on chemistry and biology of neurodegeneration, Horizon 2020 – Marie Skłodowska-Curie Innovative Training Networks

It is a plesure for us to introduce you the new European Joint Doctorate called TubInTrain. You can find more details on this ufficial Link.

Follow the project on social

Recent Advances in SARS-CoV-2 Main Protease Inhibitors: From Nirmatrelvir to Future Perspectives

Biomolecules , 2023
The current success of the SARS-CoV-2 Mpro inhibitor Nirmatrelvir, the first oral drug for the treatment of severe forms of COVID-19, has further focused the attention of researchers on this important viral target, making the search for new Mpro inhibitors a thriving and exciting field for the development of antiviral drugs active against SARS-CoV-2 and related coronaviruses.. Find out more at the link.

Recent advances in the development of CB1R selective probes

Front. Nat. Prod. , 2023
A great collaboration involving our postdoc Arianna and researchers at Uniupo has lead to this interesting review on probes for CB1R. Find out more at the link.

Synthesis and Preliminary Characterization of Putative Anle138b-Centered PROTACs against α-Synuclein Aggregation

Pharmaceutics, 2023
Fantastic work by Martina and the rest of the team on Anle138b-centered PROTACs! More about it at this Link

Synthesis of SARS-CoV-2 MPro Inhibitors bearing a Cinnamic Ester Warhead with In Vitro Activity against Human Coronaviruses

Org. Biomol. Chem., 2023
Our group has developed new Mpro inhibitors endowed with antiviral activity against human coronaviruses. Well done to Andrea and Davide for their first work as corresponding authors. To find out more details follow the Link


New frontiers of engineered nanovectors to improve treatment efficacy and safety in neurological disorders.

On January 21st, Kick-off meeting of Nevermind
“New frontiers of engineered nanovectors to improve treatment efficacy and safety in neurological disorders”

2-Hydroxyoleic Acid as a Self-Assembly Inducer for Anti-Cancer Drug-Centered Nanoparticles

Pharmaceutics, 2023
Our recent work on the use of 2-hydroxyoleic acid as a building block for the preparation of drug-conjugates containing anticancer drugs. Find out more under the Link

Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics

Chem. Eur. J., 2022
Great work by Zlata and the rest of the team on maytansinol! It was also selected as Front Cover! More about it at this Link

Notice Board

Publications of the research group

Save the date!

Upcoming webinars, seminars, conferences etc.

  • The XLVII edition of the “Attilio Corbella” International Summer School on Organic Synthesis (ISOS 2023) will take place in Gargnano (BS, Italy) from 16th to 22nd June 2023.

  • The International Summer School on Natural Products (ISSNP 2023) will take place on the 2nd-7th July 2023 Maratea, Italy.

Browse the News

challenging papers, breaking news, images and videos

The major genetic risk factor for severe COVID-19 is inherited from Neanderthals, Hugo Zeberg & Svante Pääbo, Nature, Nov 2020.
Anthony Fauci and Alberto Mantovani Webinar
Carlo Rovelli: Seminar about his new book “Helgoland”.
SARS-CoV-2 vaccines in development Nature paper
COVID-19: Drug Targets and Potential TreatmentsJournal of Medicinal Chemistry – Paper
COVID research updates
Nature wades through the literature on the new coronavirus — and summarizes key papers as they appear
Coronavirus: Research, Commentary, and News
The Science journals are striving to provide the best and most timely research, analysis, and news coverage of COVID-19
Food an Drug Administration
Agenzia Italiana del Farmaco – Vaccini COVID-19

Professor Daniele Passarella

Full Professor of Organic Chemistry
University of Milan – Department of Chemistry