TubInTrain
European Joint Doctorate on chemistry and biology of neurodegeneration, Horizon 2020 – Marie Skłodowska-Curie Innovative Training Networks
It is a plesure for us to introduce you the new European Joint Doctorate called TubInTrain. You can find more details on this ufficial Link.
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Maytansinol derivatives: side reactions as a chance for new tubulin binders
Chemistry – A European Journal, 2021
We are proud to announce our new TubInTrain manuscript which has made it to the Cover paper of Chemistry – A European Journal in 2022!
The work, focused on the maytansinoids, complex natural macrolides, brings together the computational studies, the challenging chemistry, biochemical evaluation and X-ray crystallography structure determination. To read follow Link
Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors
Chemistry – A European Journal, 2021
Check out our recently published work on new Hedgehog pathway inhibitors! Link
Nevermind
New frontiers of engineered nanovectors to improve treatment efficacy and safety in neurological disorders.
On January 21st, Kick-off meeting of Nevermind
“New frontiers of engineered nanovectors to improve treatment efficacy and safety in neurological disorders”
www.labion.eu/nevermind-project
Synthesis of potent and selective HDAC6 inhibitors led to unexpected opening of a quinazoline ring
RCS Adv., 2022
Our postdocs Davide Moi and Andrea Citarella have recently discovered the aminotriazole scaffold for HDAC6 inhibitors. To read more about the HDAC6 inhibitors developed follow Link
Brown allylation: application to the synthesis of natural products
Eur. J. Org. Chem., 2021
Our review could be useful for those interested in the asymmetric synthesis. Link
Cannabidiol as the Substrate
in Acid-Catalyzed Intramolecular Cyclization
J. Nat. Prod. 2020
Let’s go to read our article about the chemical conversion of CBD into THC’s isomers. Link
Synthesis of potent and selective HDAC6 inhibitors led to unexpected opening of a quinazoline ring
D. Moi, A. Citarella, D. Bonannia, L. Pinzia, D. Passarella, A. Silvani, C. Giannini and G. Rastelli
RSC Advances (2022)
Maytansinol derivatives: side reactions as a chance for new tubulin binders
P. Marzullo, Z.Boiarska, H. Pérez-Peña, A. Abel, B. Álvarez-Bernad, D. Lucena-Agell, F. Vasile, M. Sironi, K. Altmann, A. E. Prota, J. F. Díaz, S. Pieraccini, D. Passarella
Chemistry A European Journal (2021)
Preparation and Spectroscopic Characterization of 7R-Hydroxymatairesinol
E. Colombo, G. Paladino, U. Ciriello, D. Passarella
Molecules (2021)
Stimulus-responsive liposomes for biomedical applications
A. Antoniou, S. Giofrè, P. Senecia, D. Passarella, S. Pellegrino
Drug Discovery Today (2021)
Brown allylation: application to the synthesis of natural products
Z. Boiarska , T. Braga , A. Silvani, D. Passarella
Eur. J. Org. Chem. (2021)
Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors
E. Bonandi, M. Mori, P. Infante, I. Basili, L. Di Marcotullio, A. Calcaterra, F. Catti, B. Botta, D. Passarella
Chem. Eur. J. (2021), 27, 1-9
