PassaLab

Prof. Daniele Passarella’s Research Group
Department of Chemistry
University of Milan

Self-Assembled
Nanoparticles

Diversity-Oriented
Synthesis

Synthesis
of API

Natural Products
as Leads

TubInTrain

European Joint Doctorate on chemistry and biology of neurodegeneration, Horizon 2020 – Marie Skłodowska-Curie Innovative Training Networks

It is a plesure for us to introduce you the new European Joint Doctorate called TubInTrain. You can find more details on this ufficial Link.

Follow the project on social


Maytansinol derivatives: side reactions as a chance for new tubulin binders

Chemistry – A European Journal, 2021

We are proud to announce our new TubInTrain manuscript which has made it to the Cover paper of Chemistry – A European Journal in 2022!

The work, focused on the maytansinoids, complex natural macrolides, brings together the computational studies, the challenging chemistry, biochemical evaluation and X-ray crystallography structure determination. To read follow Link


Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors

Chemistry – A European Journal, 2021

Check out our recently published work on new Hedgehog pathway inhibitors! Link

Nevermind

New frontiers of engineered nanovectors to improve treatment efficacy and safety in neurological disorders.

On January 21st, Kick-off meeting of Nevermind
“New frontiers of engineered nanovectors to improve treatment efficacy and safety in neurological disorders”

www.labion.eu/nevermind-project


Synthesis of potent and selective HDAC6 inhibitors led to unexpected opening of a quinazoline ring

RCS Adv., 2022
Our postdocs Davide Moi and Andrea Citarella have recently discovered the aminotriazole scaffold for HDAC6 inhibitors. To read more about the HDAC6 inhibitors developed follow Link


Brown allylation: application to the synthesis of natural products

Eur. J. Org. Chem., 2021

Our review could be useful for those interested in the asymmetric synthesis. Link


Cannabidiol as the Substrate
in Acid-Catalyzed Intramolecular Cyclization

J. Nat. Prod. 2020
Let’s go to read our  article about the chemical conversion of CBD into THC’s isomers. Link

Notice Board

Publications of the research group

Browse the News

challenging papers, breaking news, images and videos

The major genetic risk factor for severe COVID-19 is inherited from Neanderthals, Hugo Zeberg & Svante Pääbo, Nature, Nov 2020. https://doi.org/10.1038/s41586-020-2818-3
Anthony Fauci and Alberto Mantovani Webinar
https://www.youtube.com/watch?v=As4E0fbqga0
Carlo Rovelli: Seminar about his new book “Helgoland”.
https://www.youtube.com/watch?v=PjFGM5gI1fobel
SARS-CoV-2 vaccines in development Nature paper
https://doi.org/10.1038/s41586-020-2798-3
COVID-19: Drug Targets and Potential TreatmentsJournal of Medicinal Chemistry – Paper
https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00606
COVID research updates
Nature wades through the literature on the new coronavirus — and summarizes key papers as they appear
https://www.nature.com/articles/d41586-020-00502-w
Coronavirus: Research, Commentary, and News
The Science journals are striving to provide the best and most timely research, analysis, and news coverage of COVID-19 https://www.sciencemag.org/collections/coronavirus
Food an Drug Administration
https://www.fda.gov/drugs
Agenzia Italiana del Farmaco – Vaccini COVID-19
https://www.aifa.gov.it/vaccini-covid-19

Save the date!

Upcoming webinars, seminars, conferences etc.

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Professor Daniele Passarella

Full Professor of Organic Chemistry
University of Milan – Department of Chemistry