TubInTrain
European Joint Doctorate on chemistry and biology of neurodegeneration, Horizon 2020 – Marie Skłodowska-Curie Innovative Training Networks
It is a plesure for us to introduce you the new European Joint Doctorate called TubInTrain. You can find more details on this ufficial Link.
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Cyrene: A Green Solvent for the Synthesis of Bioactive Molecules and Functional Biomaterials
Int. J. Mol. Sci., 2022
Discover our latest review on a cyrene, a promising green chemistry solvent! To know more follow the link.
Discovery of a Novel Trifluoromethyl Diazirine Inhibitor of SARS-CoV-2 Mpro
We have found a novel inhibitor of SARS-CoV-2 Mpro based on a trifluoromethyl diazirine. To find out more details follow the Link
Total Synthesis of (−)-Cannabidiol-C4
Dedicated to Professor Cesare Gennari on the occasion of his 70th birthday.
We have just published the total synthesis of CBD-C4 (cannabidibutol), a natural product that is present in the extracts of Cannabis.
Our PhD students performed its enantioselective synthesis using the a) 3,5-dimetoxybenzaldehyde as starting material, b) Corey-Bakshi-Shibata reduction, c) Claisen-Ireland rearrangement, d) ring-closing metathesis, and e) not-trivial demethylation induced by sodium ethanethiolate. To find out more details follow the Link
Nevermind
New frontiers of engineered nanovectors to improve treatment efficacy and safety in neurological disorders.
On January 21st, Kick-off meeting of Nevermind
“New frontiers of engineered nanovectors to improve treatment efficacy and safety in neurological disorders”
www.labion.eu/nevermind-project
Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics
Chem. Eur. J., 2022
Great work from Zlata and the rest of the team on maytansinol! It was also selected as Front Cover! More about it at this Link
Folic acid functionalization for targeting self-assembled paclitaxel-based nanoparticles
RCS Advances, 2022
Our recent work on hetero-nanoparticles self-assembled from a conjugate bearing folic acid as the targeting agent, and another bearing paclitaxel as the active agent. Find out more under the Link
Stereoselective Synthetic Strategies to (−)-Cannabidiol
ChemistrySelect, 2022
To learn about the challenges in the stereoselective synthesis of (−)-cannabidiol and the ways to overcome them, check our new review! Link
Discovery of a Novel Trifluoromethyl Diazirine Inhibitor of SARS-CoV-2 Mpro
A. Citarella, D. Moi, M. Pedrini, H. Pérez-Peña, S. Pieraccini, C. Stagno, N. Micale, T. Schirmeister, G. Sibille, G. Gribaudo, A. Silvani, D. Passarella, C. Giannini
Molecules (2023)
Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics
Z. Boiarska, H. Pérez-Peña, A.-C. Abel, P. Marzullo, B. Álvarez-Bernad, F. Bonato, B. Santini, D. Horvath, D. Lucena-Agell, F. Vasile, M. Sironi, J. F. Díaz, A. E. Prota, S. Pieraccini, D. Passarella
Chem. Eur. J. (2022)
Cyrene: A Green Solvent for the Synthesis of Bioactive Molecules and Functional Biomaterials
A. Citarella, A. Amenta, D. Passarella, N. Micale
Int. J. Mol. Sci. (2022)
Folic acid functionalization for targeting self-assembled paclitaxel-based nanoparticles
E. Colombo, D.A. Coppini, S. Maculan, P. Seneci, B. Santini, F. Testa, L. Salvioni, G. Vanacore, M. Colombo, D. Passarella
RSC Advances (2022)
Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors
A. Tinivella, J. C. Nwachukwu, A. Angeli, F. Foschi, A. L. Benatti, L. Pinzi, T. Izard, M. Ferraroni, R. Erumbi, M. S. Christodoulou, D. Passarella, C. T. Supuran, K. W. Nettles, G. Rastelli
European Journal of Medicinal Chemistry (2022)
Dual-functionalized liposomes for selective delivery of poorly soluble drugs to inflamed brain regions
S. Giofrè, A. Renda, S. Sesana, B. Formicola, B. Vergani, B.E. Leone, V. Denti, G. Paglia, S. Groppuso, V. Romeo, L. Muzio, A. Balboni, A. Menegon, A. Antoniou, A. Amenta, D. Passarella, P. Seneci, S. Pellegrino, F. Re
Pharmaceutics (2022)
- The XLVII edition of the “Attilio Corbella” International Summer School on Organic Synthesis (ISOS 2023) will take place in Gargnano (BS, Italy) from 16th to 22nd June 2023.
https://corbellasummerschool.unimi.it/
- The International Summer School on Natural Products (ISSNP 2023) will take place on the 2nd-7th July 2023 Maratea, Italy.
