The optimization of the synthesis of Active Pharmaceutical Ingredients is challenging and extremely important.
The synthesis of silodosin2 and Migrastatin3 analogs are good examples.
References
[1] E. Bonandi, D. Passarella et al. Phytochemistry Reviews 2020, DOI :10.1007/s11101-020-09702-8
[2] F. Calogero, P. Allegrini, E. Attolino, D. Passarella Eur.J.Org.Chem.2015, 27, 6011-6016
]3] A. Gabba, P. V. Murphy, D. Passarella et al. Eur.J.Org.Chem.2017, 60-69 DOI: 10.1002/ejoc.201600988