Publications

(Last 5 years)


PITX2 gain-of-function mutation associated with atrial fibrillation alters mitochondrial activity in human iPSC atrial-like cardiomyocytes

Patrizia Benzoni, Lorenzo Da Dalt, Noemi Elia, Vera Popolizio, Alessandro Cospito, Federica Giannetti,
Patrizia Dell’Era, Morten S. Olesen, Annalisa Bucchi, Mirko Baruscotti, Giuseppe Danilo Norata, Andrea Barbuti


Modeling incomplete penetrance in arrhythmogenic cardiomyopathy by human induced pluripotent stem cell derived cardiomyocytes

Marzia De Bortoli, Viviana Meraviglia, Katarina Mackova, Laura S. Frommelt, Eva König, Johannes Rainer, Chiara Volani, Patrizia Benzoni, Maja Schlittler, Giada Cattelan, Benedetta M. Motta, Claudia Volpato, Werner Rauhe, Andrea Barbuti, Serena Zacchigna, Peter P. Pramstaller, Alessandra Rossini


Lack of the transcription factor Nfix causes tachycardia in mice sinus node and rats neonatal cardiomyocytes

Sara Landi, Federica Giannetti, Patrizia Benzoni, Giulia Campostrini, Giuliana Rossi, Chiara Piantoni, Giorgia Bertoli, Chiara Bonfanti, Luca Carnevali, Annalisa Bucchi, Mirko Baruscotti, Giorgia Careccia, Graziella Messina, Andrea Barbuti


Modeling incomplete penetrance in arrhythmogenic cardiomyopathy by human induced pluripotent stem cell derived cardiomyocytes

Marzia De Bortoli, Viviana Meraviglia, Katarina Mackova, Laura S. Frommelt, Eva König, Johannes Rainer, Chiara Volani, Patrizia Benzoni, Maja Schlittler, Giada Cattelan, Benedetta M. Motta, Claudia Volpato, Werner Rauhe, Andrea Barbuti, Serena Zacchigna, Peter P. Pramstaller, Alessandra Rossini


Age-Related Changes in Cardiac Autonomic Modulation and Heart Rate Variability in Mice

Chiara Piantoni, Luca Carnevali, David Molla, Andrea Barbuti, Dario DiFrancesco, Annalisa Bucchi, Mirko Baruscotti


A detailed characterization og the hyperpolarization-activated “funny” current in human-induced pluripotent stem cell (iPSC)-derived cardiomyocytes with pacemaker activity

Federica Giannetti, Patrizia Benzoni, Giulia Campostrini, Rafaella Milanesi, Annalisa Bucchi, Mirko Baruscotti, Patrizia Dell’Era, Alessandra Rossini, Andrea Barbuti.


PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction

Da Dalt L, Castiglioni L, Baragetti A, Audano M, Svecla M, Bonacina F, Pedretti S, Uboldi P, Benzoni P, Giannetti F, Barbuti A, Pellegatta F, Indino S, Donetti E, Sironi L, Mitro N, Catapano AL, Norata GD. Eur Heart J (2021) 42, 3078–3090, doi:10.1093/eurheartj/ehab431.


The funny current_even funnier than 40 years ago. uncanonical expression and roles of HCN-f channles all over the body

Benzoni P, Bertoli G, Giannetti F, Piantoni C, Milanesi R, Pecchiari M, Barbuti A, Baruscotti M, Bucchi A. Prog Biophys Mol Biol. 2021 Aug 14:S0079-6107(21)00100-0. doi: 10.1016/j.pbiomolbio.2021.08.007. Online ahead of print.


Age-Related Changes in Cardiac Autonomic Modulation and Heart Rate Variability in Mice

Piantoni C, Carnevali L, Molla D, Barbuti A, DiFrancesco D, Bucchi A and Baruscotti M. Front. Neurosci., 17 May 2021 doi.org/10.3389/fnins.2021.617698


Dual Role of miR-1 in the development and function of sinoatrial cells

Benzoni P, Nava L, Giannetti F, Guerini G, Gualdoni A, Bazzini C, Milanesi R, Bucchi A, Baruscotti M, Barbuti A. J Mol Cell Cardiol. 2021 May 6;157:104-112. doi: 10.1016/j.yjmcc.2021.05.001. Online ahead of print.


A detailed characterization of the hyperpolarization‑activated “funny” current (If) in human‑induced pluripotent stem cell (iPSC)–derived cardiomyocytes with pacemaker activity

Giannetti F, Benzoni P, Campostrini G, Milanesi R, Bucchi A, Baruscotti M, Dell’Era P, Rossini A and Barbuti A. Pflugers Arch. 2021 May 2. doi: 10.1007/s00424-021-02571-w. Online ahead of print.


A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate

D’Souza A, Wang Y, Anderson C, Bucchi A, Barsucotti M, Olieslagers S, Mesirca P, Johnsen AB, Mastitskaya S, Ni H, Zhang Y, Black N, Cox C, Wegner S, Bano- Otalora B, Petit C, Gill E, Logantha SJ, Dobrzynski H, Ashton N, Hart G, Zhang R, Zhang H, Cartwright EJ, Wisloff U, Mangoni ME, Da Costa Martins P, Piggins HD, DiFrancesco D, Boyett MR. Heart Rhythm. 2020 Nov 27:S1547-5271(20)31130-9. doi: 10.1016/j.hrthm.2020.11.026. Epub ahead of print. PMID: 33278629.


High content screening identifies licoisoflavone A as a bioactive compound of Tongmaiyangxin Pills to restrain cardiomyocyte hypertrophy via activating Sirt3

D’Souza A, Wang Y, Anderson C, Bucchi A, Barsucotti M, Olieslagers S, Mesirca P, Johnsen AB, Mastitskaya S, Ni H, Zhang Y, Black N, Cox C, Wegner S, Bano- Otalora B, Petit C, Gill E, Logantha SJ, Dobrzynski H, Ashton N, Hart G, Zhang R, Zhang H, Cartwright EJ, Wisloff U, Mangoni ME, Da Costa Martins P, Piggins HD, DiFrancesco D, Boyett MR. Heart Rhythm. 2020 Nov 27:S1547-5271(20)31130-9. doi: 10.1016/j.hrthm.2020.11.026. Epub ahead of print. PMID: 33278629.


Human iPSC modelling of a familial form of atrial fibrillation reveals a gain of function of If and ICaL in patient-derived cardiomyocytes

Benzoni P, Campostrini G, Landi S, Bertini V, Marchina E, Iascone M, Ahlberg G, Olesen MS, Crescini E, Mora C, Bisleri G, Muneretto C, Ronca R, Presta M, Poliani PL, Piovani G, Verardi R, Di Pasquale E, Consiglio A, Raya A, Torre E, Lodrini AM, Milanesi R, Rocchetti M, Baruscotti M, DiFrancesco D, Memo M, Barbuti A, Dell’Era P. Cardiovasc Res. 2020 May 1;116(6):1147-1160. doi: 10.1093/cvr/cvz217. PMID: 31504264; PMCID: PMC7177512.


Generation of the induced human pluripotent stem cell lines CSSi009-A from a patient with a GNB5 pathogenic variant, and CSSi010-A from a CRISPR/Cas9 engineered GNB5 knock-out human cell line.

Malerba N, Benzoni P, Squeo GM, Milanesi R, Giannetti F, Sadleir LG, Poke G, Augello B, Croce AI, Barbuti A, Merla G. Stem Cell Res. 2019 Oct;40:101547. doi: 10.1016/j.scr.2019.101547. Epub 2019 Aug 22. PMID: 31479876.\


Optical Investigation of Action Potential and Calcium Handling Maturation of hiPSC-Cardiomyocytes on Biomimetic Substrates

Pioner JM, Santini L, Palandri C, Martella D, Lupi F, Langione M, Querceto S, Grandinetti B, Balducci V, Benzoni P, Landi S, Barbuti A, Ferrares Lupi F, Boarino L, Sartiani L, Tesi C, Mack DL, Regnier M, Cerbai E, Parmeggiani C, Poggesi C, Ferrantini C, Coppini R.. Int J Mol Sci. 2019 Aug 3;20(15):3799. doi: 10.3390/ijms20153799. PMID: 31382622; PMCID: PMC6695920.


HCN ion channels and accessory proteins in epilepsy: genetic analysis of a large cohort of patients and review of the literature.

DiFrancesco JC, Castellotti B, Milanesi R, Ragona F, Freri E, Canafoglia L, Franceschetti S, Ferrarese C, Magri S, Taroni F, Costa C, Labate A, Gambardella A, Solazzi R, Binda A, Rivolta I, Di Gennaro G, Casciato S, D’Incerti L, Barbuti A, DiFrancesco D, Granata T, Gellera C. Epilepsy Res. 2019 Jul;153:49-58. doi: 10.1016/j.eplepsyres.2019.04.004. Epub 2019 Apr 8. PMID: 30986657.