Recent Publications

Synthesis of α-fluorocinnamate derivatives as novel cathepsin S inhibitors with in vitro antiproliferative activity against pancreatic cancer cells

Bioorganic & Medicinal Chemistry 2024, 115, 117987

Andrea Citarella*, Serena Petrella, Davide Moi, Alessandro Dimasi, Tommaso Braga, Lorenzo Ruberto, Stefano Pieraccini, Maurizio Sironi, Nicola Micale, Tanja Schirmeister, Giovanna Damia, Valerio Fasano, Alessandra Silvani, Clelia Giannini and Daniele Passarella

A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy

RSC Med. Chem., 2024, Advance Article, DOI: 10.1039/D4MD00517A

Arianna Amenta, Susanna Comi, Marcelo Kravicz, Silvia Sesana, Antonia Antoniou, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino and Francesca Re *

Cu-Catalyzed Asymmetric Synthesis of γ-Amino Alcohols Featuring Tertiary Carbon Stereocenters

Org. Lett. 2024, DOI: 10.1021/acs.orglett.4c02682

Alejandro Delgado, Paolo Orlando, Matteo Lanzi*, Jordi Benet-Buchholz, Daniele Passarella, Arjan W. Kleij*

Nicotinic Acid Derivatives As Novel Noncompetitive α-Amylase and α-Glucosidase Inhibitors for Type 2 Diabetes Treatment

ACS Med. Chem. Lett, 2024, DOI: 10.1021/acsmedchemlett.4c00190

Andrea Citarella*, Miriam Cavinato, Elena Rosini, Haidi Shehi, Federico Ballabio, Carlo Camilloni, Valerio Fasano, Alessandra Silvani, Daniele Passarella, Loredano Pollegioni and Marco Nardini*

Minor Cannabinoids as Inhibitors of Skin Inflammation: Chemical Synthesis and Biological Evaluation

J. Nat. Prod. 2024, DOI: 10.1021/acs.jnatprod.4c00212

Alice Maiocchi, Marco Fumagalli, Manuel Vismara, Asja Blanco, Umberto Ciriello, Giuseppe Paladino, Stefano Piazza, Giulia Martinelli, Valerio Fasano, Mario Dell’Agli and Daniele Passarella*

Total Synthesis of an Epothilone Analogue based on the Amide‒Triazole Bioisosterism

ChemPlusChem 2024, e202400413

Eleonora Colombo, Davide Andrea Coppini, Simone Borsoi, Valerio Fasano, Raffaella Bucci, Francesca Bonato, Elisa Bonandi, Francesca Vasile, Stefano Pieraccini and Daniele Passarella*

Nirmatrelvir: From Discovery to Modern and Alternative Synthetic Approaches

Processes 2024, 12(6), 1242

Michela Galli^†, Francesco Migliano^†, Valerio Fasano , Alessandra Silvani , Daniele Passarella and Andrea Citarella^*

Quantitative Live Cell Imaging of a Tauopathy model enables the Identiﬁcation of a Polypharmacological Drug Candidate that Restores Physiological Microtubule Interaction

Nature Communications, 2024, 15, 1779

Luca Pinzi, Christian Conze, Nicolo Bisi, Gabriele Dalla Torre, Ahmed Soliman, Nanci Monteiro-Abreu, Nataliya I. Trushina, Andrea Krusenbaum, Maryam Khodaei Dolouei, Andrea Hellwig, Michael S. Christodoulou, Daniele Passarella, Lidia Bakota, Giulio Rastelli* and Roland Brandt*

Synthesis of α-fluorocinnamate derivatives as novel cathepsin S inhibitors with in vitro antiproliferative activity against pancreatic cancer cells

A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy

Cu-Catalyzed Asymmetric Synthesis of γ-Amino Alcohols Featuring Tertiary Carbon Stereocenters

Nicotinic Acid Derivatives As Novel Noncompetitive α-Amylase and α-Glucosidase Inhibitors for Type 2 Diabetes Treatment

Minor Cannabinoids as Inhibitors of Skin Inflammation: Chemical Synthesis and Biological Evaluation

Total Synthesis of an Epothilone Analogue based on the Amide‒Triazole Bioisosterism

Nirmatrelvir: From Discovery to Modern and Alternative Synthetic Approaches

Quantitative Live Cell Imaging of a Tauopathy model enables the Identiﬁcation of a Polypharmacological Drug Candidate that Restores Physiological Microtubule Interaction

Syntheses, Reactivity, and Biological Applications of Coumarins

First total synthesis of caerulomycin K: a case study on selective, multiple C–H functionalizations of pyridines

A Green Approach to Nucleophilic Aromatic Substitutions of Nicotinic Esters in Cyrene

Targeting Ovarian Cancer with chalcone Derivatives: Cytotoxicity and Apoptosis Induction in HGSOC Cells