Amino acids, Peptidomimetics, peptides, protein InteractionS group
Hereditary gelsolin amyloidosis (AGel) is a rare and often underrecognized protein misfolding disorder caused by mutations in the gelsolin (GSN) protein, leading to its aggregation in various tissues. Its rarity, combined with a heterogeneous...
Electrochemical Response alfa/ß-peptides: Influence of thePeptide Length, Stereochemistry and Self-Assembly on the Performance of Peptide-Based Electrochemical Sensors The electrochemical response of alfa-beta-peptides with (L-Ala-ß-Fpg)n sequence, where ß-Fpg refers to syn acid, has been investigated...
Current cancer therapies for solid cancers involve surgery, radiotherapy, and chemotherapy, but challenges such as tumor heterogeneity, drug resistance, and poor drug delivery hinder effective treatment. Nano-oncology, specifically liposomes, shows promise by improving drug...
New diastereoisomeric isoxazoline scaffolds bearing two amino-alkyl chains were synthesized using a 1,3-dipolar cycloaddition reaction, with the aim to prepare N-to-N parallel β-hairpins. Two approaches were employed, both starting from methyl(azidomethyl)acrylate as dipolarophile, and...
The QK peptide is a 15-residue VEGF-mimetic compound known for its proangiogenic activity. Its helical conformation plays a crucial role in binding to VEGF receptors, activating intracellular signaling pathways in endothelial cells, promoting cell...
Cardiovascular diseases are the leading cause of death worldwide, claiming millions of lives every year. Cardiac tissue engineering has emerged as a versatile option for repairing cardiac tissue and helping its regeneration. The use...
The late-stage peptide functionalization with salicylaldehyde (SA) tags is described here as a versatile design of potential Lys-engaging, reversible-covalent ligands. This approach was applied to a known binder for NEMO, a protein involved in...
Hybrid biomolecules composed of short peptides and nucleic acid analogues can self-assemble and are good candidates toproduce new materials thanks to their biocompatibility and versatility.The assembly occurs by exploiting hydrogen bonds and stacking interactions...
Antimicrobial peptides (AMPs) have great potential to be developed as topical treatments for microbial infections of the skin, including those caused by the gram-positive human pathogen Staphylococcus aureus. Among the AMPs, temporin B (TB)...
A large number of drugs are characterized by limited brain penetrability. The development of advanced delivery systems, such as nanoparticles, may help overcome the blood–brain barrier (BBB) and increase brain accessibility (Spinelli et al.,...
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