Amino acids, Peptidomimetics, peptides, protein InteractionS group
New diastereoisomeric isoxazoline scaffolds bearing two amino-alkyl chains were synthesized using a 1,3-dipolar cycloaddition reaction, with the aim to prepare N-to-N parallel β-hairpins. Two approaches were employed, both starting from methyl(azidomethyl)acrylate as dipolarophile, and...
The QK peptide is a 15-residue VEGF-mimetic compound known for its proangiogenic activity. Its helical conformation plays a crucial role in binding to VEGF receptors, activating intracellular signaling pathways in endothelial cells, promoting cell...
Tau is a microtubule-associated protein essential for regulating microtubule dynamics and axonal transport in neurons. In tauopathies, the transition of tau from a physiological to a pathological form remains unclear, though the hexapeptides PHF6...
peptides / Peptidomimetics / unnatural amino acid
di emanuela erba · Published 21 Novembre 2024 · Last modified 22 Novembre 2024
Now a days, peptidomimetics are widely studied, being useful tools in drug discovery and medicinal chemistry. The coupling between a carboxylic acid with an amine to form a peptide bond is the most common...
di emanuela erba · Published 2 Maggio 2024 · Last modified 26 Settembre 2024
Supramolecular gels were developed by taking advantage of an assembly of small dipeptides containing pyrrolo-pyrazole scaffolds. The dipeptides were prepared through a robust and ecofriendly synthetic approach from the commercially available starting materials of...
application / nanofibers / Peptidomimetics
di emanuela erba · Published 8 Aprile 2024 · Last modified 26 Settembre 2024
We prepared a small library of short peptidomimetics based on 3-pyrrolo-pyrazole carboxylate, a non-coded γ-amino acid, and glycine or alanine. The robust and eco-friendly synthetic approach adopted allows to obtain the dipeptides in two...
di emanuela erba · Published 27 Marzo 2024 · Last modified 26 Settembre 2024
Though the bulk of the COVID-19 pandemic is behind, the search for effective and safea anti-SARS-CoV-2 drugs continues to be relevant. A highly pursued approach for antiviral drug development involves targeting the viral spike...
Protein-mimetic peptides (PMPs) are shorter sequences of self-assembling proteins, that represent remarkable building blocks for the generation of bioinspired functional supramolecular structures with multiple applications.The identification of novel aminoacidic sequences that permit the access...
Gelsolin amyloidosis (AGel) is characterized by multiple systemic and ophthalmic features resulting from pathological tissue deposition of the gelsolin (GSN) protein. To date, no cure is available for the treatment of any form of...
Aggregation-induced emissive materials are gaining particular attention in the last decades due to their wide application in different fields, from optical devices to biomedicine. In this work, compounds having these kinds of properties, composed...
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