Amino acids, Peptidomimetics, peptides, protein InteractionS group
Gelsolin amyloidosis (Agel) is a hereditary systemic disorder caused by point mutations in the gelsolin (GSN) gene that promote aberrant proteolytic processing and deposition of amyloidogenic fragments. The most prevalent variant, D187N, destabilizes the...
Multilayered films composed of two different materials, where the less conducting one acts as adielectric separating the layers made of the other, are known to function as efficient electrodes for electrochemical supercapacitors. In this...
Hereditary gelsolin amyloidosis (AGel) is a rare and often underrecognized protein misfolding disorder caused by mutations in the gelsolin (GSN) protein, leading to its aggregation in various tissues. Its rarity, combined with a heterogeneous...
New diastereoisomeric isoxazoline scaffolds bearing two amino-alkyl chains were synthesized using a 1,3-dipolar cycloaddition reaction, with the aim to prepare N-to-N parallel β-hairpins. Two approaches were employed, both starting from methyl(azidomethyl)acrylate as dipolarophile, and...
The QK peptide is a 15-residue VEGF-mimetic compound known for its proangiogenic activity. Its helical conformation plays a crucial role in binding to VEGF receptors, activating intracellular signaling pathways in endothelial cells, promoting cell...
Tau is a microtubule-associated protein essential for regulating microtubule dynamics and axonal transport in neurons. In tauopathies, the transition of tau from a physiological to a pathological form remains unclear, though the hexapeptides PHF6...
peptides / Peptidomimetics / unnatural amino acid
di emanuela erba · Published 21 Novembre 2024 · Last modified 22 Novembre 2024
Now a days, peptidomimetics are widely studied, being useful tools in drug discovery and medicinal chemistry. The coupling between a carboxylic acid with an amine to form a peptide bond is the most common...
di emanuela erba · Published 2 Maggio 2024 · Last modified 26 Settembre 2024
Supramolecular gels were developed by taking advantage of an assembly of small dipeptides containing pyrrolo-pyrazole scaffolds. The dipeptides were prepared through a robust and ecofriendly synthetic approach from the commercially available starting materials of...
application / nanofibers / Peptidomimetics
di emanuela erba · Published 8 Aprile 2024 · Last modified 26 Settembre 2024
We prepared a small library of short peptidomimetics based on 3-pyrrolo-pyrazole carboxylate, a non-coded γ-amino acid, and glycine or alanine. The robust and eco-friendly synthetic approach adopted allows to obtain the dipeptides in two...
di emanuela erba · Published 27 Marzo 2024 · Last modified 26 Settembre 2024
Though the bulk of the COVID-19 pandemic is behind, the search for effective and safea anti-SARS-CoV-2 drugs continues to be relevant. A highly pursued approach for antiviral drug development involves targeting the viral spike...
Altro
comments