Amino acids, Peptidomimetics, peptides, protein InteractionS group
Electrochemical Response alfa/ß-peptides: Influence of thePeptide Length, Stereochemistry and Self-Assembly on the Performance of Peptide-Based Electrochemical Sensors The electrochemical response of alfa-beta-peptides with (L-Ala-ß-Fpg)n sequence, where ß-Fpg refers to syn acid, has been investigated...
The late-stage peptide functionalization with salicylaldehyde (SA) tags is described here as a versatile design of potential Lys-engaging, reversible-covalent ligands. This approach was applied to a known binder for NEMO, a protein involved in...
Antimicrobial peptides (AMPs) have great potential to be developed as topical treatments for microbial infections of the skin, including those caused by the gram-positive human pathogen Staphylococcus aureus. Among the AMPs, temporin B (TB)...
A large number of drugs are characterized by limited brain penetrability. The development of advanced delivery systems, such as nanoparticles, may help overcome the blood–brain barrier (BBB) and increase brain accessibility (Spinelli et al.,...
In nature, organisms living in extreme environmental conditions produce antifreeze proteins (AFPs) that prevent the growth of ice crystals and depress the freezing point of body fluids. In this study, three different peptides derived...
peptides / Peptidomimetics / unnatural amino acid
di emanuela erba · Published 21 Novembre 2024 · Last modified 22 Novembre 2024
Now a days, peptidomimetics are widely studied, being useful tools in drug discovery and medicinal chemistry. The coupling between a carboxylic acid with an amine to form a peptide bond is the most common...
application / catalysis / peptides
di emanuela erba · Published 11 Settembre 2024 · Last modified 12 Settembre 2024
Self-assembled peptides are used for diverse applications in the biomedical and technological fields. The morphology and function of the assembled systems are dictated by the peptide sequence and length. In thiswork, a supramolecular catalyst...
Aggregation-induced emitting (AIE) luminophores are sensitive and easy-to-handle types of robes that allow driving a stimulus-responsive off/on optical tool through the manipulation of the aggregation behavior. In this work, tetraphenylethene (TPE)-phenylalanine derivatives, haracterized by...
application / peptides / unnatural amino acid
di emanuela erba · Published 3 Gennaio 2024 · Last modified 12 Settembre 2024
Structures composed of alternating α and β amino acids can give rise to peculiar secondary structural motifs, which could self-assemble into complex structures of controlled geometries. This work describes the self-assembly properties of an...
peptides / unnatural amino acid
di emanuela erba · Published 3 Gennaio 2024 · Last modified 26 Settembre 2024
A dimeric cyclic cysteine analogue, i.e. (1R,1’R,2R,2’R)-2,2’-disulfanediylbis (aminocyclohexane-1-carboxylic acid), was used as a constrained unnatural amino acid and as a folding inducer in ultra-short Leu-Val-containing peptide. Our results showed that both free dimer amino...
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