Apis group Amino acids, Peptidomimetics, peptides, protein InteractionS group


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A Non-coded β2,2-Amino Acid with Isoxazoline Core Able to Stabilize Peptides Folding Through an Unprecedented Hydrogen Bond

New peptidomimetics containing a β2,2-isoxazoline amino acid, i.e. 5-(aminomethyl)-3-phenyl-4,5-dihydroisoxazole- 5-carboxylic acid (Isox-β2,2AA), were prepared and studied by NMR and theoretical calculation. Although similar amino acid derivatives have already been prepared via 1,3-dipolar cycloaddition reaction,...

L- to D‑Amino Acid Substitution in the Immunodominant LCMV Derived Epitope gp33 Highlights the Sensitivity of the TCR Recognition Mechanism for the MHC/Peptide Structure and Dynamics

Presentation of pathogen-derived epitopes by major histocompatibility complex I (MHC-I) can lead to the activation and expansion of specificCD8+ T cell clones, eventually resulting in the destruction of infected target cells. Altered peptide ligands...