Amino acids, Peptidomimetics, peptides, protein InteractionS group
Gelsolin amyloidosis (Agel) is a hereditary systemic disorder caused by point mutations in the gelsolin (GSN) gene that promote aberrant proteolytic processing and deposition of amyloidogenic fragments. The most prevalent variant, D187N, destabilizes the...
Multilayered films composed of two different materials, where the less conducting one acts as adielectric separating the layers made of the other, are known to function as efficient electrodes for electrochemical supercapacitors. In this...
Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disease characterized by a broad range of clinical manifestations. The lack of disease-specific therapies presents important challenges in the treatment of this disease. Targeted drug delivery...
Hereditary gelsolin amyloidosis (AGel) is a rare and often underrecognized protein misfolding disorder caused by mutations in the gelsolin (GSN) protein, leading to its aggregation in various tissues. Its rarity, combined with a heterogeneous...
Electrochemical Response alfa/ß-peptides: Influence of thePeptide Length, Stereochemistry and Self-Assembly on the Performance of Peptide-Based Electrochemical Sensors The electrochemical response of alfa-beta-peptides with (L-Ala-ß-Fpg)n sequence, where ß-Fpg refers to syn acid, has been investigated...
Current cancer therapies for solid cancers involve surgery, radiotherapy, and chemotherapy, but challenges such as tumor heterogeneity, drug resistance, and poor drug delivery hinder effective treatment. Nano-oncology, specifically liposomes, shows promise by improving drug...
New diastereoisomeric isoxazoline scaffolds bearing two amino-alkyl chains were synthesized using a 1,3-dipolar cycloaddition reaction, with the aim to prepare N-to-N parallel β-hairpins. Two approaches were employed, both starting from methyl(azidomethyl)acrylate as dipolarophile, and...
The QK peptide is a 15-residue VEGF-mimetic compound known for its proangiogenic activity. Its helical conformation plays a crucial role in binding to VEGF receptors, activating intracellular signaling pathways in endothelial cells, promoting cell...
Cardiovascular diseases are the leading cause of death worldwide, claiming millions of lives every year. Cardiac tissue engineering has emerged as a versatile option for repairing cardiac tissue and helping its regeneration. The use...
The late-stage peptide functionalization with salicylaldehyde (SA) tags is described here as a versatile design of potential Lys-engaging, reversible-covalent ligands. This approach was applied to a known binder for NEMO, a protein involved in...
Gelsolin amyloidosis (Agel) is a hereditary systemic disorder caused by point mutations in the gelsolin (GSN) gene that promote aberrant proteolytic processing and deposition of amyloidogenic fragments. The most prevalent variant, D187N, destabilizes the...
Multilayered films composed of two different materials, where the less conducting one acts as adielectric separating the layers made of the other, are known to function as efficient electrodes for electrochemical supercapacitors. In this...
Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disease characterized by a broad range of clinical manifestations. The lack of disease-specific therapies presents important challenges in the treatment of this disease. Targeted drug delivery...
Hereditary gelsolin amyloidosis (AGel) is a rare and often underrecognized protein misfolding disorder caused by mutations in the gelsolin (GSN) protein, leading to its aggregation in various tissues. Its rarity, combined with a heterogeneous...
Electrochemical Response alfa/ß-peptides: Influence of thePeptide Length, Stereochemistry and Self-Assembly on the Performance of Peptide-Based Electrochemical Sensors The electrochemical response of alfa-beta-peptides with (L-Ala-ß-Fpg)n sequence, where ß-Fpg refers to syn acid, has been investigated...
Current cancer therapies for solid cancers involve surgery, radiotherapy, and chemotherapy, but challenges such as tumor heterogeneity, drug resistance, and poor drug delivery hinder effective treatment. Nano-oncology, specifically liposomes, shows promise by improving drug...
New diastereoisomeric isoxazoline scaffolds bearing two amino-alkyl chains were synthesized using a 1,3-dipolar cycloaddition reaction, with the aim to prepare N-to-N parallel β-hairpins. Two approaches were employed, both starting from methyl(azidomethyl)acrylate as dipolarophile, and...
The QK peptide is a 15-residue VEGF-mimetic compound known for its proangiogenic activity. Its helical conformation plays a crucial role in binding to VEGF receptors, activating intracellular signaling pathways in endothelial cells, promoting cell...
Cardiovascular diseases are the leading cause of death worldwide, claiming millions of lives every year. Cardiac tissue engineering has emerged as a versatile option for repairing cardiac tissue and helping its regeneration. The use...
The late-stage peptide functionalization with salicylaldehyde (SA) tags is described here as a versatile design of potential Lys-engaging, reversible-covalent ligands. This approach was applied to a known binder for NEMO, a protein involved in...
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