Amino acids, Peptidomimetics, peptides, protein InteractionS group
The aim was to investigate the role of the constrained AA, the anchor point (at C- or Nterminus) and the peptide length on their potential use as gold binding motif.
Colloidal gold nanoparticles (GNPs) have found wide-ranging applications in nanomedicine due to their unique optical properties, ease of preparation, and functionalization. To avoid the formation of GNP aggregates in the physiological environment, molecules such...
The aim was to investigate the role of the constrained AA, the anchor point (at C- or Nterminus) and the peptide length on their potential use as gold binding motif.
Colloidal gold nanoparticles (GNPs) have found wide-ranging applications in nanomedicine due to their unique optical properties, ease of preparation, and functionalization. To avoid the formation of GNP aggregates in the physiological environment, molecules such...
application / Peptidomimetics / Review
di emanuela erba · Published 27 Settembre 2021 · Last modified 5 Ottobre 2021
Electrospinning is a well-known, straightforward, and versatile technique, widely used for the preparation of fibers by electrifying a polymer solution. However, a high molecular weight is not essential for obtaining uniform electrospun fibers; in...
The main goal in developing peptidomimetics is the stabilization of the bioactive conformation of peptides. Among all the secondary structures, turns are of paramount importance. This review highlights the recent advances in the design...
The chemical structure of oligonucleotide analogues dictates the conformation of oligonucleotide analogue oligomers, their ability to hybridize complementary DNA and RNA, their stability to degradation and their pharmacokinetic properties. In a study aimed at...
Based on the supramolecular interaction between vancomycin (Van), an antibiotic glycopeptide, and D-Ala-D-Ala (DADA) dipeptides, a novel class of artificial metalloenzymes was synthesized and characterized. The presence of an iridium(III) ligand at the N-terminus...
Nanofiber films produced by electrospinning currently provide a promising platform for different appli- cations. Although nonfunctionalized nanofiber films from natural or synthetic polymers are extensively used, electrospun materials combined with peptides are gaining more...
application / News / Peptidomimetics / unnatural amino acid
di emanuela erba · Published 30 Novembre 2020 · Last modified 11 Febbraio 2021
Bioinspired smart materials represent a tremendously growing research field and the obtainment of new building blocks is at the molecular basis of this technology progress. In this work, colloidal materials have been prepared in...
application / Peptidomimetics / unnatural amino acid
di emanuela erba · Published 27 Ottobre 2020 · Last modified 10 Febbraio 2021
A new non-natural β-amino acid, named 3-Ar-β-Morph, was designed and synthesized via a regio- and diastereoselective Pdcatalyzed C(sp3)H-arylation of the corresponding 2S,6S-(6-methoxymorpholin-2-yl)carboxylic acid, readily available from glucose. According to the computational prevision and confirmed...
di emanuela erba · Published 9 Ottobre 2020 · Last modified 27 Ottobre 2020
The exploitation of self-assembled systems to improve the solubility of drugs is getting more and more attention. Among the different types of self-assembled biomaterials, peptides and in particular peptides containing non-coded amino acids (NCAPs)...
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