APIS group

Amino acids, Peptidomimetics, peptides, protein InteractionS group

Apis group Amino acids, Peptidomimetics, peptides, protein InteractionS group

application / unnatural amino acid

Aqueous self-assembly of short hydrophobic peptides containing norbornene amino acid into supramolecular structures with spherical shape

RSC Adv., 2016,6, 90754-90759 DOI: 10.1039/C6RA17116H formation of supramolecular assembly is reported. The two diastereoisomeric pentapeptides AcAla- NRB-Ala-Aib-AlaNH2 1 and 2 containing the two enantiomers of non-proteinogenic norbornene amino acid (NRB) were synthesized in...

application / unnatural amino acid

Ctr-1 Mets7 motif inspiring new peptide ligands for Cu(I)-catalyzed asymmetric Henry reactions under green conditions

RSC Adv., 2016,6, 71529-71533 DOI: 10.1039/C6RA16255J Taking inspiration from the Ctr-1 Mets7 Cu(I) binding motif, effective hybrid catalysts have been developed for asymmetric Henry condensations under green conditions. The introduction of an unnatural dipeptide...

application

Structural insight into the interaction of O‐acetylserine sulfhydrylase with competitive, peptidic inhibitors by saturation transfer difference‐NMR

  FEBS Letters 590 (2016) 943–953 ª 2016 Federation of European Biochemical Societies doi:10.1002/1873-3468.12126 O-acetylserine sulfhydrylase (OASS), the enzyme catalysing the last step of cysteine biosynthesis in bacteria, is involved in antibiotic resistance and...

News

MoGlyNet

The Horizon 2020 MSCA joint doctoral project MoGlyNet (“Modulation of glycolytic flux as a new approach for treatment of atherosclerosis and plaque stabilization: a multidisciplinary study”) is run by a Consortium of Universities in...

application / unnatural amino acid

Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted β2,3-Diarylamino Acid and L‑Alanine as Candidates for Biomedical Applications

 The synthesis and the structural characterization of dipeptides composed of unnatural fluorine-substituted β2,3-diarylamino acid and L-alanine are reported. Depending on the stereochemistry of the β amino acid, these dipeptides are able to self-assemble into proteolytic stable nanotubes....

unnatural amino acid

1H-Azepine-2-oxo-5-amino-5-carboxylic Acid: A 310 Helix Inducer and an Effective Tool for Functionalized Gold Nanoparticles

A new α,α-disubstituted constrained glutamine analogue has been designed to decorate gold nanoparticles and to induce a 310-helix when inserted in peptides. Using an efficient “one-pot” asymmetric Schmidt reaction between 4-disubstituted-cyclohexanone and hydroxyalkylazides, 1H-azepine-2-oxo-5-amino-5-carboxylic...

Peptidomimetics

Model peptides containing the 3-sulfanylnorbornene

The properties of the constrained tetrasubstituted 3-sulfanylnorbornene amino acid (NRB), when inserted in Ala-Aib model peptides, were extensively studied. The conformational behaviour of these models was evaluated by theoretical calculations, spectroscopic analyses and by...

application

Promising antiproliferative platinum(II) complexes based on imidazole moiety: synthesis, evaluation in HCT-116 cancer cell line and interaction with Ctr-1 Met-rich domain

  Promising antiproliferative platinum(II) complexes based on imidazole moiety: synthesis, evaluation in HCT-116 cancer cell line and interaction with Ctr-1 Met-rich domain doi:10.1016/j.bmc.2015.03.044 A series of imidazole based platinum(II) complexes were synthesised and evaluated...