Amino acids, Peptidomimetics, peptides, protein InteractionS group
application / Peptidomimetics / unnatural amino acid
di emanuela erba · Published 27 Ottobre 2017 · Last modified 21 Gennaio 2022
Tetrahydroisoquinoline-4-carboxylic acid, a constrained beta-2-amino acid named beta-TIC, wassy in the sised for the first time in enantiopure form .The biocatalytic route applied herein represents one of the few successful examples of enzymatic resolu...
application / unnatural amino acid
di emanuela erba · Published 27 Ottobre 2017 · Last modified 21 Gennaio 2022
The development of molecular carriers able to carry molecules directly into the cell is an area of intensive research. Cationic nanoparticles are effective delivery systems for several classes of molecules, such as anticancer agents,...
application / Peptidomimetics / unnatural amino acid
di emanuela erba · Published 2 Febbraio 2017 · Last modified 21 Gennaio 2022
Amino acids are the building blocks of peptides and proteins. In million years of evolution, Nature has optimized their structures to absolve numerous functions in almost all the biological processes. They are indeed able...
The development of mitochondria-targeting cell permeable vectors represents a promising therapeutic approach for several diseases, such as cancer and oxidative pathologies. Nevertheless, access to mitochondria can be difficult. A new hybrid material composed by...
application / unnatural amino acid
di emanuela erba · Published 2 Febbraio 2017 · Last modified 21 Gennaio 2022
An advanced intermediate in the synthesis of the racemic Neuraminidase inhibitor Peramivir was synthesised in a new and versatile manner starting from a stereoselective 1,3-dipolar cycloaddition reaction between the nitrile oxide deriving from 2-ethylbutanal...
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