Peptide modulators of Rac1/Tiam1 protein-protein interaction: An alternative approach for cardiovascular diseases
Rac1 GTPase interaction with guanine nucleotide exchange factor Tiam1 is involved in several cancer types and cardiovascular diseases.
Apis group Amino acids, Peptidomimetics, peptides, protein InteractionS group
Tandem Tetrahydroisoquinoline-4-carboxylic Acid/beta-Alanineasa New Construct Able To Induce a Flexible Turn
Tetrahydroisoquinoline-4-carboxylic acid, a constrained beta-2-amino acid named beta-TIC, wassy in the sised for the first time in enantiopure form .The biocatalytic route applied herein represents one of the few successful examples of enzymatic resolu...
Self-assembly of an amphipathic ααβ-tripeptide into cationic spherical particles for intracellular delivery
The development of molecular carriers able to carry molecules directly into the cell is an area of intensive research. Cationic nanoparticles are effective delivery systems for several classes of molecules, such as anticancer agents,...
Non-standard amino acids and peptides: From self-assembly to nanomaterials
Amino acids are the building blocks of peptides and proteins. In million years of evolution, Nature has optimized their structures to absolve numerous functions in almost all the biological processes. They are indeed able...
Development of poly(lactide-co-glycolide) nanoparticles functionalized with a mitochondria penetrating peptide
The development of mitochondria-targeting cell permeable vectors represents a promising therapeutic approach for several diseases, such as cancer and oxidative pathologies. Nevertheless, access to mitochondria can be difficult. A new hybrid material composed by...
A novel synthetic approach to the racemic Neuraminidase inhibitor Peramivir
An advanced intermediate in the synthesis of the racemic Neuraminidase inhibitor Peramivir was synthesised in a new and versatile manner starting from a stereoselective 1,3-dipolar cycloaddition reaction between the nitrile oxide deriving from 2-ethylbutanal...
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