Amino acids, Peptidomimetics, peptides, protein InteractionS group
Protein aggregation into amyloid fibrils is the archetype of aberrant biomolecular selfassembly processes, with more than 50 associated diseases that are mostly uncurable.Understanding aggregation mechanisms is thus of fundamental importance and goes inparallel with...
Temporin B (TB) is a 13-amino-acid-long, cationic peptide secreted by the granular glands of the European frog Rana temporaria. We recently showed that the modified TB peptide analog TB_KKG6K rapidly killed planktonic and sessile...
Temporins are short peptides secreted by frogs from all over the world. They exert antimicrobial activity, mainly against Gram-positive bacteria, including resistant pathogens; recent studies highlight other possible applications of these peptides as anticancer...
application / unnatural amino acid
di emanuela erba · Published 10 Dicembre 2023 · Last modified 3 Gennaio 2024
We reported on the synthesis of new organocatalysts belonging to the class of ß-morpholine amino acids that were tested in a model reaction
Gelsolin amyloidosis (AGel) is characterized by multiple systemic and ophthalmic features resulting from pathological tissue deposition of the gelsolin (GSN) protein. To date, no cure is available for the treatment of any form of...
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Aggregation-induced emissive materials are gaining particular attention in the last decades due to their wide application in different fields, from optical devices to biomedicine. In this work, compounds having these kinds of properties, composed...
application / nanoparticles / Review
di emanuela erba · Published 20 Agosto 2022 · Last modified 20 Ottobre 2022
Liposomes are amphipathic lipidic supramolecular aggregates that are able to encapsulate and carry molecules of both hydrophilic and hydrophobic nature. They have been widely used as in vivo drug delivery systems for some time...
New peptidomimetics containing a β2,2-isoxazoline amino acid, i.e. 5-(aminomethyl)-3-phenyl-4,5-dihydroisoxazole- 5-carboxylic acid (Isox-β2,2AA), were prepared and studied by NMR and theoretical calculation. Although similar amino acid derivatives have already been prepared via 1,3-dipolar cycloaddition reaction,...
In our previous study, we had identified a 9-mer peptide (FSHβ (89–97)) derived from seat belt loop of human FSHβ and demonstrated its ability to function as FSHR antagonist in vivo. Structure analysis revealed...
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