Amino acids, Peptidomimetics, peptides, protein InteractionS group
di emanuela erba · Published 7 Novembre 2016 · Last modified 21 Gennaio 2022
Chem. Sci., 2017, 8, 1295–1302 DOI: 10.1039/C6SC03176E Alzheimer’s disease is a neurodegenerative disorder linked to oligomerization and fibrillization of amyloid b peptides, with Ab1–42 being the most aggregative and neurotoxic one. We report herein...
The theoretical basis behind the ability of constrained Cα-tetrasubstituted amino acids (CTAAs) to induce stable helical conformations has been studied through Replica Exchange Molecular Dynamics, Potential of Mean Force and Quantum Theory of...
The properties of the constrained tetrasubstituted 3-sulfanylnorbornene amino acid (NRB), when inserted in Ala-Aib model peptides, were extensively studied. The conformational behaviour of these models was evaluated by theoretical calculations, spectroscopic analyses and by...
Altro
comments