Peptide modulators of Rac1/Tiam1 protein-protein interaction: An alternative approach for cardiovascular diseases
Rac1 GTPase interaction with guanine nucleotide exchange factor Tiam1 is involved in several cancer types and cardiovascular diseases.
Peptidomimetics
Tandem Tetrahydroisoquinoline-4-carboxylic Acid/beta-Alanineasa New Construct Able To Induce a Flexible Turn
Tetrahydroisoquinoline-4-carboxylic acid, a constrained beta-2-amino acid named beta-TIC, wassy in the sised for the first time in enantiopure form .The biocatalytic route applied herein represents one of the few successful examples of enzymatic resolu...
Non-standard amino acids and peptides: From self-assembly to nanomaterials
Amino acids are the building blocks of peptides and proteins. In million years of evolution, Nature has optimized their structures to absolve numerous functions in almost all the biological processes. They are indeed able...
beta-Hairpin mimics containing a piperidine– pyrrolidine scaffold modulate the beta-amyloid aggregation process preserving the monomer species
Chem. Sci., 2017, 8, 1295–1302 DOI: 10.1039/C6SC03176E Alzheimer’s disease is a neurodegenerative disorder linked to oligomerization and fibrillization of amyloid b peptides, with Ab1–42 being the most aggregative and neurotoxic one. We report herein...
Mechanism of Stabilization of Helix Secondary Structure by Constrained Cα-Tetrasubstituted α-Amino Acids
The theoretical basis behind the ability of constrained Cα-tetrasubstituted amino acids (CTAAs) to induce stable helical conformations has been studied through Replica Exchange Molecular Dynamics, Potential of Mean Force and Quantum Theory of...
Model peptides containing the 3-sulfanylnorbornene
The properties of the constrained tetrasubstituted 3-sulfanylnorbornene amino acid (NRB), when inserted in Ala-Aib model peptides, were extensively studied. The conformational behaviour of these models was evaluated by theoretical calculations, spectroscopic analyses and by...
comments