Amino acids, Peptidomimetics, peptides, protein InteractionS group
application / Peptidomimetics / unnatural amino acid
di emanuela erba · Published 2 Febbraio 2017 · Last modified 21 Gennaio 2022
Amino acids are the building blocks of peptides and proteins. In million years of evolution, Nature has optimized their structures to absolve numerous functions in almost all the biological processes. They are indeed able...
di emanuela erba · Published 7 Novembre 2016 · Last modified 21 Gennaio 2022
Chem. Sci., 2017, 8, 1295–1302 DOI: 10.1039/C6SC03176E Alzheimer’s disease is a neurodegenerative disorder linked to oligomerization and fibrillization of amyloid b peptides, with Ab1–42 being the most aggregative and neurotoxic one. We report herein...
The theoretical basis behind the ability of constrained Cα-tetrasubstituted amino acids (CTAAs) to induce stable helical conformations has been studied through Replica Exchange Molecular Dynamics, Potential of Mean Force and Quantum Theory of...
The properties of the constrained tetrasubstituted 3-sulfanylnorbornene amino acid (NRB), when inserted in Ala-Aib model peptides, were extensively studied. The conformational behaviour of these models was evaluated by theoretical calculations, spectroscopic analyses and by...
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