Parkinson’sdisease

Alpha-synuclein (αSyn) is a small presynapticprotein (14kDa) that is involved insynucleinopathies including Parkinson’sdisease (PD). In itsnativestate, theαSynmonomerexistsinanunfoldedstate,anditsfoldingishighlydependentonvariationsof environmental conditions,mutations and interactionswithendogenous and/orexogenousmolecules. Recently, there is increasingevidence for adirect interplaybetweenαSynandmicrotubules(MTs),whosedefectsarelinkedtoneurodegenerativediseases, suchasPD.Understanding thecorrelationbetweenαSynandMTscouldbefundamental forthecorrectcomprehensionoftheundergoingmechanismsofPD.Hence,wechemicallysynthesizeda library of...