application / unnatural amino acid

L- to D‑Amino Acid Substitution in the Immunodominant LCMV Derived Epitope gp33 Highlights the Sensitivity of the TCR Recognition Mechanism for the MHC/Peptide Structure and Dynamics

Presentation of pathogen-derived epitopes by major histocompatibility complex I (MHC-I) can lead to the activation and expansion of specificCD8+ T cell clones, eventually resulting in the destruction of infected target cells. Altered peptide ligands...