2022

 

Di Pisa F, De Benedetti S, Fassi EMA, Bombaci M, Grifantini R, Musico A, Frigerio R, Pontillo A, Rigo C, Abelli S, Grande R, Zanchetta N, Mileto D, Mancon A, Rizzo A, Gori A, Cretich M, Colombo G, Bolognesi M, Gourlay LJ. Elucidating the 3D Structure of a Surface Membrane Antigen from Trypanosoma cruzi as a Serodiagnostic Biomarker of Chagas Disease. Vaccines (Basel). 2022 Jan 3;10(1):71. doi: 10.3390/vaccines10010071. PMID: 35062732; PMCID: PMC8781870.

 

Quilici G, Berardi A, Fabris C, Ghitti M, Punta M, Gourlay LJ, Bolognesi M, Musco G. Solution Structure of the BPSL1445 Protein of Burkholderia pseudomallei Reveals the SYLF Domain Three-Dimensional Fold. ACS Chem Biol. 2022 Jan 21;17(1):230-239. doi: 10.1021/acschembio.1c00886. Epub 2021 Dec 30. PMID: 34968022.

Ballabio F, Broggini L, Paissoni C, Han X, Peqini K, Sala BM, Sun R, Sandalova T, Barbiroli A, Achour A, Pellegrino S, Ricagno S, Camilloni C. l- to d-Amino Acid Substitution in the Immunodominant LCMV-Derived Epitope gp33 Highlights the Sensitivity of the TCR Recognition Mechanism for the MHC/Peptide Structure and Dynamics. ACS Omega. 2022 Mar 7;7(11):9622-9635. doi: 10.1021/acsomega.1c06964. PMID: 35350306; PMCID: PMC8945122.

 

Russo R, Romeo M, Schulte T, Maritan M, Oberti L, Barzago MM, Barbiroli A, Pappone C, Anastasia L, Palladini G, Diomede L, Ricagno S. Cu(II) Binding Increases the Soluble Toxicity of Amyloidogenic Light Chains. Int J Mol Sci. 2022 Jan 16;23(2):950. doi: 10.3390/ijms23020950. PMID: 35055136; PMCID: PMC8780072.

 

Nardini M, Pesce A, Bolognesi M. Truncated (2/2) hemoglobin: Unconventional structures and functional roles in vivo and in human pathogenesis. Mol Aspects Med. 2022 Apr;84:101049. doi: 10.1016/j.mam.2021.101049. Epub 2021 Nov 12. PMID: 34776271.

 

Mazzini G, Ricagno S, Caminito S, Rognoni P, Milani P, Nuvolone M, Basset M, Foli A, Russo R, Merlini G, Palladini G, Lavatelli F. Protease-sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation. FEBS J. 2022 Jan;289(2):494-506. doi: 10.1111/febs.16182. Epub 2021 Sep 15. PMID: 34482629.

 

 

2021

 

Varotto-Boccazzi I, Manenti A, Dapporto F, Gourlay LJ, Bisaglia B, Gabrieli P, Forneris F, Faravelli S, Bollati V, Rubolini D, Zuccotti G, Montomoli E, Epis S, Bandi C. Epidemic Preparedness-Leishmania tarentolae as an Easy-to-Handle Tool to Produce Antigens for Viral Diagnosis: Application to COVID-19. Front Microbiol. 2021 Dec 13;12:736530. doi: 10.3389/fmicb.2021.736530. PMID: 34966362; PMCID: PMC8710741.

 

Bernardini A, Lorenzo M, Chaves-Sanjuan A, Swuec P, Pigni M, Saad D, Konarev PV, Graewert MA, Valentini E, Svergun DI, Nardini M, Mantovani R, Gnesutta N. The USR domain of USF1 mediates NF-Y interactions and cooperative DNA binding. Int J Biol Macromol. 2021 Dec 15;193(Pt A):401-413. doi: 10.1016/j.ijbiomac.2021.10.056. Epub 2021 Oct 18. PMID: 34673109.

 

Bollati M, Diomede L, Giorgino T, Natale C, Fagnani E, Boniardi I, Barbiroli A, Alemani R, Beeg M, Gobbi M, Fakin A, Mastrangelo E, Milani M, Presciuttini G, Gabellieri E, Cioni P, de Rosa M. A novel hotspot of gelsolin instability triggers an alternative mechanism of amyloid aggregation. Comput Struct Biotechnol J. 2021 Nov 19;19:6355-6365. doi: 10.1016/j.csbj.2021.11.025. PMID: 34938411; PMCID: PMC8649582.

 

de Rosa M, Nonnis S, Aliverti A. Covalent inhibition of P. falciparum ferredoxin-NADP+ reductase: Exploring alternative strategies for the development of new antimalarial drugs. Biochem Biophys Res Commun. 2021 Nov 5;577:89-94. doi: 10.1016/j.bbrc.2021.09.008. Epub 2021 Sep 4. PMID: 34509083.

 

Van Dycke J, Puxeddu M, La Regina G, Mastrangelo E, Tarantino D, Rymenants J, Sebastiani J, Nalli M, Matthijnssens J, Neyts J, Silvestri R, Rocha-Pereira J. Discovery of a Novel Class of Norovirus Inhibitors with High Barrier of Resistance. Pharmaceuticals (Basel). 2021 Sep 30;14(10):1006. doi: 10.3390/ph14101006. PMID: 34681230; PMCID: PMC8537218.

 

 

Cossu F, Camelliti S, Lecis D, Sorrentino L, Majorini MT, Milani M, Mastrangelo E. Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-κB pathway. Comput Struct Biotechnol J. 2021 Nov 26;19:6366-6374. doi: 10.1016/j.csbj.2021.11.034. PMID: 34938412; PMCID: PMC8649670.

 

D'Acunto E, Fra A, Visentin C, Manno M, Ricagno S, Galliciotti G, Miranda E. Neuroserpin: structure, function, physiology and pathology. Cell Mol Life Sci. 2021 Aug 17. doi: 10.1007/s00018-021-03907-6. Epub ahead of print. PMID: 34405255.

 

Mangiagalli M, Barbiroli A, Santambrogio C, Ferrari C, Nardini M, Lotti M, Brocca S. The activity and stability of a cold-active acylaminoacyl peptidase rely on its dimerization by domain swapping. Int J Biol Macromol. 2021 Jun 30;181:263-274. doi: 10.1016/j.ijbiomac.2021.03.150. Epub 2021 Mar 26. PMID: 33775759.

 

Saponaro A, Bauer D, Giese MH, Swuec P, Porro A, Gasparri F, Sharifzadeh AS, Chaves-Sanjuan A, Alberio L, Parisi G, Cerutti G, Clarke OB, Hamacher K, Colecraft HM, Mancia F, Hendrickson WA, Siegelbaum SA, DiFrancesco D, Bolognesi M, Thiel G, Santoro B, Moroni A. Gating movements and ion permeation in HCN4 pacemaker channels. Mol Cell. 2021 Jul 15;81(14):2929-2943.e6. doi: 10.1016/j.molcel.2021.05.033. Epub 2021 Jun 23. PMID: 34166608; PMCID: PMC8294335.

Paissoni C, Puri S, Wang I, Chen SY, Camilloni C, Hsu SD. Converging experimental and computational views of the knotting mechanism of a small knotted protein. Biophys J. 2021 Jun 1;120(11):2276-2286. doi: 10.1016/j.bpj.2021.03.032. Epub 2021 Apr 1. PMID: 33812848; PMCID: PMC8390826.

 

Cocomazzi P, Tarantino D, Mastrangelo E, Aliverti A. Ligand Binding in Allosteric Flavoproteins: Part 2. Quantitative Analysis of the Redox-Dependent Interaction of the Apoptosis-Inducing Factor (AIF) with Its Protein Partner. Methods Mol Biol. 2021;2280:189-198. doi: 10.1007/978-1-0716-1286-6_12. PMID: 33751436.

 

Paissoni C, Camilloni C. How to Determine Accurate Conformational Ensembles by Metadynamics Metainference: A Chignolin Study Case. Front Mol Biosci. 2021 May 26;8:694130. doi: 10.3389/fmolb.2021.694130. PMID: 34124166; PMCID: PMC8187852.

 

Delgado L, Heckmann CM, Di Pisa F, Gourlay L, Paradisi F. Release of Soybean Isoflavones by Using a β-Glucosidase from Alicyclobacillus herbarius. Chembiochem. 2021 Apr 6;22(7):1223-1231. doi: 10.1002/cbic.202000688. Epub 2020 Dec 30. PMID: 33237595; PMCID: PMC8048572.

 

Saad D, Paissoni C, Chaves-Sanjuan A, Nardini M, Mantovani R, Gnesutta N, Camilloni C. High Conformational Flexibility of the E2F1/DP1/DNA Complex. J Mol Biol. 2021 Sep 3;433(18):167119. doi: 10.1016/j.jmb.2021.167119. Epub 2021 Jun 25. PMID: 34181981.

 

De Benedetti S, Di Pisa F, Fassi EMA, Cretich M, Musicò A, Frigerio R, Mussida A, Bombaci M, Grifantini R, Colombo G, Bolognesi M, Grande R, Zanchetta N, Gismondo MR, Mileto D, Mancon A, Gourlay LJ. Structure, Immunoreactivity, and In Silico Epitope Determination of SmSPI S. mansoni Serpin for Immunodiagnostic Application. Vaccines (Basel). 2021 Apr 1;9(4):322. doi: 10.3390/vaccines9040322. PMID: 33915716; PMCID: PMC8066017.

 

Ahmed MC, Skaanning LK, Jussupow A, Newcombe EA, Kragelund BB, Camilloni C, Langkilde AE, Lindorff-Larsen K. Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods. Front Mol Biosci. 2021 Apr 22;8:654333. doi: 10.3389/fmolb.2021.654333. PMID: 33968988; PMCID: PMC8100456.

 

Hofbauer D, Mougiakakos D, Broggini L, Zaiss M, Büttner-Herold M, Bach C, Spriewald B, Neumann F, Bisht S, Nolting J, Zeiser R, Hamarsheh S, Eberhardt M, Vera J, Visentin C, De Luca CMG, Moda F, Haskamp S, Flamann C, Böttcher M, Bitterer K, Völkl S, Mackensen A, Ricagno S, Bruns H. β2-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression. Immunity. 2021 Aug 10;54(8):1772-1787.e9. doi: 10.1016/j.immuni.2021.07.002. Epub 2021 Jul 20. PMID: 34289378.

 

Gornati D, Ciccone R, Vinciguerra A, Ippati S, Pannaccione A, Petrozziello T, Pizzi E, Hassan A, Colombo E, Barbini S, Milani M, Caccavone C, Randazzo P, Muzio L, Annunziato L, Menegon A, Secondo A, Mastrangelo E, Pignataro G, Seneci P. Synthesis and Characterization of Novel Mono- and Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult. J Med Chem. 2021 Jun 24;64(12):8333-8353. doi: 10.1021/acs.jmedchem.1c00305. Epub 2021 Jun 7. PMID: 34097384.

 

Cocomazzi P, Sorrentino L, Cossu F, Aliverti A. Ligand Binding in Allosteric Flavoproteins: Part 1. Quantitative Analysis of the Interaction with NAD+ of the Apoptosis Inducing Factor (AIF) Harboring FAD in the Reduced State. Methods Mol Biol. 2021;2280:179-187. doi: 10.1007/978-1-0716-1286-6_11. PMID: 33751435.

 

Potrc M, Volk M, de Rosa M, Pizem J, Teran N, Jaklic H, Maver A, Drnovsek-Olup B, Bollati M, Vogelnik K, Hocevar A, Gornik A, Pfeifer V, Peterlin B, Hawlina M, Fakin A. Clinical and Histopathological Features of Gelsolin Amyloidosis Associated with a Novel GSN Variant p.Glu580Lys. Int J Mol Sci. 2021 Jan 22;22(3):1084. doi: 10.3390/ijms22031084. PMID: 33499149; PMCID: PMC7865823.

 

Milani M, Donalisio M, Bonotto RM, Schneider E, Arduino I, Boni F, Lembo D, Marcello A, Mastrangelo E. Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors. Antiviral Res. 2021 Mar 10:105055. doi: 10.1016/j.antiviral.2021.105055. Epub ahead of print. PMID: 33713730.

 

Potrc M, Volk M, de Rosa M, Pizem J, Teran N, Jaklic H, Maver A, Drnovsek-Olup B, Bollati M, Vogelnik K, Hocevar A, Gornik A, Pfeifer V, Peterlin B, Hawlina M, Fakin A. Clinical and Histopathological Features of Gelsolin Amyloidosis Associated with a Novel GSN Variant p.Glu580Lys. Int J Mol Sci. 2021 Jan 22;22(3):1084. doi: 10.3390/ijms22031084. PMID: 33499149; PMCID: PMC7865823.

 

Delgado L, Heckmann CM, De Benedetti S, Nardini M, Gourlay LJ, Paradisi F. Producing natural vanilla extract from green vanilla beans using a β-glucosidase from Alicyclobacillus acidiphilus. J Biotechnol. 2021 Mar 10;329:21-28. doi: 10.1016/j.jbiotec.2021.01.017. Epub 2021 Jan 27. PMID: 33508335.

 

Rabuffetti M, Cannazza P, Contente ML, Pinto A, Romano D, Hoyos P, Alcantara AR, Eberini I, Laurenzi T, Gourlay L, Di Pisa F, Molinari F. Structural insights into the desymmetrization of bulky 1,2-dicarbonyls through enzymatic monoreduction. Bioorg Chem. 2021 Mar;108:104644. doi: 10.1016/j.bioorg.2021.104644. Epub 2021 Jan 11. PMID: 33486371.

 

De Simone G, di Masi A, Pesce A, Bolognesi M, Ciaccio C, Tognaccini L, Smulevich G, Abbruzzetti S, Viappiani C, Bruno S, Monaca SD, Pietraforte D, Fattibene P, Coletta M, Ascenzi P. Mycobacterial and Human Ferrous Nitrobindins: Spectroscopic and Reactivity Properties. Int J Mol Sci. 2021 Feb 7;22(4):1674. doi: 10.3390/ijms22041674. PMID: 33562340; PMCID: PMC7915275