Recent Publications

Access to Highly Functional and Polymerizable Carbonate-Drug Conjugates

ChemSusChem 2025, DOI: 10.1002/cssc.202500031

Wangyu Shi, Thirusangumurugan Senthamarai, Matteo Lanzi, Paolo Orlando, Rodrigo Nogués Martín, Arjan W. Kleij

Design, synthesis and in vitro validation of bivalent binders of SARS-CoV-2 spike protein: Obeticholic, betulinic and glycyrrhetinic acids as building blocks

Bioorganic & Medicinal Chemistry 2025, DOI: 10.1016/j.bmc.2025.118124

Martina Pedrini †, Luca Pozzi †, Francesca Sacchi, Andrea Citarella*, Valerio Fasano, Pierfausto Seneci, Stefano Pieraccini, Lorenzo Ruberto, Helena Perez Peña, Alfredo Garzino-Demo, Adriana Vitiello, Leonardo Sernicola, Alessandra Borsetti, Arianna Calistri, Cristina Parolin and Daniele Passarella*

Revisiting the Reduction of Vinpocetine

ChemistrySelect 2025, 10, e202406175, DOI: 10.1002/slct.202406175

Simone Borsoi, Luca Pozzi, Valerio Fasano, Andrea Citarella, Giovanni Macetti, Leonardo Lo Presti, Giuseppe Paladino, Umberto Ciriello and Daniele Passarella*

Mechanistic insights into the base-mediated deuteration of pyridyl phosphonium and ammonium salts

RSC Advances 2025, 15, 870 – 874, DOI: 10.1039/D4RA07557A

Arianna Montoli, Alessandro Dimasi, Miriana Guarnaccia, Andrea Citarella, Paolo Ronchi, Delia Blasi, Sergio Rossi, Daniele Passarella and Valerio Fasano*

Metal-free, Selective Ortho-Deuteration of N-heterocyclic Oxides

Advanced Synthesis and Catalysis 2025, e202401585,DOI: 10.1002/adsc.202401585

Arianna Montoli, Alessandro Dimasi, Andrea Citarella, Paolo Ronchi, Daniele Passarella and Valerio Fasano*

Sustainable Synthesis of 1,2,3-Triazoles using Cyrene as a Biodegradable Solvent in Click Chemistry

ChemSusChem 2025, e202402538, DOI: 10.1002/cssc.202402538

Andrea Citarella*, Alessandro Fiori, Alessandra Silvani, Daniele Passarella and Valerio Fasano*

An Inducible Neural Stem Progenitor Cell Model forTesting Therapeutic Interventions AgainstNeurodegeneration FENIB

Drug Development Research, 2025, 86:e70041, DOI: 10.1002/ddr.70041

Alessandro Giustini, Alice Maiocchi, Ilaria Serangeli, Martina Pedrini, Anna Quintiliani, Valentina Sabato, Francesca Bonato, Pierfausto Seneci, Giuseppe Lupo, Daniele Passarella, Elena Miranda

Synthesis of α-fluorocinnamate derivatives as novel cathepsin S inhibitors with in vitro antiproliferative activity against pancreatic cancer cells

Bioorganic & Medicinal Chemistry 2024, 115, 117987

Andrea Citarella*, Serena Petrella, Davide Moi, Alessandro Dimasi, Tommaso Braga, Lorenzo Ruberto, Stefano Pieraccini, Maurizio Sironi, Nicola Micale, Tanja Schirmeister, Giovanna Damia, Valerio Fasano, Alessandra Silvani, Clelia Giannini and Daniele Passarella

Access to Highly Functional and Polymerizable Carbonate-Drug Conjugates

Design, synthesis and in vitro validation of bivalent binders of SARS-CoV-2 spike protein: Obeticholic, betulinic and glycyrrhetinic acids as building blocks

Revisiting the Reduction of Vinpocetine

Mechanistic insights into the base-mediated deuteration of pyridyl phosphonium and ammonium salts

Metal-free, Selective Ortho-Deuteration of N-heterocyclic Oxides

Sustainable Synthesis of 1,2,3-Triazoles using Cyrene as a Biodegradable Solvent in Click Chemistry

An Inducible Neural Stem Progenitor Cell Model forTesting Therapeutic Interventions AgainstNeurodegeneration FENIB

Synthesis of α-fluorocinnamate derivatives as novel cathepsin S inhibitors with in vitro antiproliferative activity against pancreatic cancer cells

A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy

Cu-Catalyzed Asymmetric Synthesis of γ-Amino Alcohols Featuring Tertiary Carbon Stereocenters

Nicotinic Acid Derivatives As Novel Noncompetitive α-Amylase and α-Glucosidase Inhibitors for Type 2 Diabetes Treatment

Minor Cannabinoids as Inhibitors of Skin Inflammation: Chemical Synthesis and Biological Evaluation