Recent Publications

Design, synthesis and characterization of aryl bis-guanyl hydrazones as RNA binders of C9orf72 G4C2 extended repeats

European Journal of Medicinal Chemistry, 2025, 293, 117736, DOI: 10.1016/j.ejmech.2025.117736

Alice Maiocchi, Martina Pedrini, Veronica Ferrari, Agata Sofia Assunçao Carreira, Vincenzo Maria D’Amore, Federica Santoro, Anna Di Porzio, Maddalena Bosetti, Riccardo Cristofani, Alessandra Silvani, Diego Brancaccio, Luciana Marinelli, Francesco Saverio Di Leva, Alessandro Provenzani, Angelo Poletti, Pierfausto Seneci

Automated fluorine-18 radiolabeling via an alkyne–azide cycloaddition reaction on a dual peptide-functionalized liposome surface for in vivo PET imaging

Frontiers in Pharmacology, 2025, 16, 1–16. DOI: 10.3389/fphar.2025.1566257

Marco Iannone, Marcelo Kravicz, Paolo Rainone, Antonia I. Antoniou, Stefano Stucchi, Silvia Valtorta, Arianna Amenta, Elia Anna Turolla, Sara Pellegrino, Daniele Passarella, Elisa Vino, Sergio Todde, Francesca Re, Pierfausto Seneci, Rosa Maria Moresco

Self-Assembled Cannabigerol-Based Nanoparticles: Design, Synthesis, and Antiproliferative Activity

Pharmaceutics 2025, 17(5), 636; DOI: 10.3390/pharmaceutics17050636

Arianna Amenta, Giulia Nordio, Francesco Piazzola, Maria Luisa Di Paolo, Fabio Milani, Martina Giacomini,
Andrea Citarella,* Umberto Ciriello, Giuseppe Paladino, Sara Pellegrino, Federica Silvestri, Valerio Fasano,
Lisa Dalla Via* e Daniele Passarella

Access to Highly Functional and Polymerizable Carbonate-Drug Conjugates

ChemSusChem 2025, DOI: 10.1002/cssc.202500031

Wangyu Shi, Thirusangumurugan Senthamarai, Matteo Lanzi, Paolo Orlando, Rodrigo Nogués Martín, Arjan W. Kleij

Design, synthesis and in vitro validation of bivalent binders of SARS-CoV-2 spike protein: Obeticholic, betulinic and glycyrrhetinic acids as building blocks

Bioorganic & Medicinal Chemistry 2025, DOI: 10.1016/j.bmc.2025.118124

Martina Pedrini †, Luca Pozzi †, Francesca Sacchi, Andrea Citarella*, Valerio Fasano, Pierfausto Seneci, Stefano Pieraccini, Lorenzo Ruberto, Helena Perez Peña, Alfredo Garzino-Demo, Adriana Vitiello, Leonardo Sernicola, Alessandra Borsetti, Arianna Calistri, Cristina Parolin and Daniele Passarella*

Revisiting the Reduction of Vinpocetine

ChemistrySelect 2025, 10, e202406175, DOI: 10.1002/slct.202406175

Simone Borsoi, Luca Pozzi, Valerio Fasano, Andrea Citarella, Giovanni Macetti, Leonardo Lo Presti, Giuseppe Paladino, Umberto Ciriello and Daniele Passarella*

Mechanistic insights into the base-mediated deuteration of pyridyl phosphonium and ammonium salts

RSC Advances 2025, 15, 870 – 874, DOI: 10.1039/D4RA07557A

Arianna Montoli, Alessandro Dimasi, Miriana Guarnaccia, Andrea Citarella, Paolo Ronchi, Delia Blasi, Sergio Rossi, Daniele Passarella and Valerio Fasano*

Metal-free, Selective Ortho-Deuteration of N-heterocyclic Oxides

Advanced Synthesis and Catalysis 2025, e202401585,DOI: 10.1002/adsc.202401585

Arianna Montoli, Alessandro Dimasi, Andrea Citarella, Paolo Ronchi, Daniele Passarella and Valerio Fasano*

Sustainable Synthesis of 1,2,3-Triazoles using Cyrene as a Biodegradable Solvent in Click Chemistry

ChemSusChem 2025, e202402538, DOI: 10.1002/cssc.202402538

Andrea Citarella*, Alessandro Fiori, Alessandra Silvani, Daniele Passarella and Valerio Fasano*

An Inducible Neural Stem Progenitor Cell Model forTesting Therapeutic Interventions AgainstNeurodegeneration FENIB

Drug Development Research, 2025, 86:e70041, DOI: 10.1002/ddr.70041

Alessandro Giustini, Alice Maiocchi, Ilaria Serangeli, Martina Pedrini, Anna Quintiliani, Valentina Sabato, Francesca Bonato, Pierfausto Seneci, Giuseppe Lupo, Daniele Passarella, Elena Miranda

Synthesis of α-fluorocinnamate derivatives as novel cathepsin S inhibitors with in vitro antiproliferative activity against pancreatic cancer cells

Bioorganic & Medicinal Chemistry 2024, 115, 117987

Andrea Citarella*, Serena Petrella, Davide Moi, Alessandro Dimasi, Tommaso Braga, Lorenzo Ruberto, Stefano Pieraccini, Maurizio Sironi, Nicola Micale, Tanja Schirmeister, Giovanna Damia, Valerio Fasano, Alessandra Silvani, Clelia Giannini and Daniele Passarella

A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy

RSC Med. Chem., 2024, Advance Article, DOI: 10.1039/D4MD00517A

Arianna Amenta, Susanna Comi, Marcelo Kravicz, Silvia Sesana, Antonia Antoniou, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino and Francesca Re *