APIS group

Amino acids, Peptidomimetics, peptides, protein InteractionS group

unnatural amino acid

peptides / unnatural amino acid

Exploitation of Dimeric Cyclic Cysteine as Helix Inducer in Ultra-Short Peptides for Cu(II)-Catalyzed Asymmetric Michael Addition on Chalcones

A dimeric cyclic cysteine analogue, i.e. (1R,1’R,2R,2’R)-2,2’-disulfanediylbis (aminocyclohexane-1-carboxylic acid), was used as a constrained unnatural amino acid and as a folding inducer in ultra-short Leu-Val-containing peptide. Our results showed that both free dimer amino...

application / unnatural amino acid

L- to D‑Amino Acid Substitution in the Immunodominant LCMV Derived Epitope gp33 Highlights the Sensitivity of the TCR Recognition Mechanism for the MHC/Peptide Structure and Dynamics

Presentation of pathogen-derived epitopes by major histocompatibility complex I (MHC-I) can lead to the activation and expansion of specificCD8+ T cell clones, eventually resulting in the destruction of infected target cells. Altered peptide ligands...

application / News / Peptidomimetics / unnatural amino acid

Nucleobase morpholino β amino acids as molecular chimeras for the preparation of photoluminescent materials from ribonucleosides

Bioinspired smart materials represent a tremendously growing research field and the obtainment of new building blocks is at the molecular basis of this technology progress. In this work, colloidal materials have been prepared in...

application / Peptidomimetics / unnatural amino acid

Non-natural 3‑Arylmorpholino-β-amino Acid as a PPII Helix Inducer

A new non-natural β-amino acid, named 3-Ar-β-Morph, was designed and synthesized via a regio- and diastereoselective Pdcatalyzed C(sp3)H-arylation of the corresponding 2S,6S-(6-methoxymorpholin-2-yl)carboxylic acid, readily available from glucose. According to the computational prevision and confirmed...