Amino acids, Peptidomimetics, peptides, protein InteractionS group
application / catalysis / peptides
di emanuela erba · Published 11 Settembre 2024 · Last modified 12 Settembre 2024
Self-assembled peptides are used for diverse applications in the biomedical and technological fields. The morphology and function of the assembled systems are dictated by the peptide sequence and length. In thiswork, a supramolecular catalyst...
Aggregation-induced emitting (AIE) luminophores are sensitive and easy-to-handle types of robes that allow driving a stimulus-responsive off/on optical tool through the manipulation of the aggregation behavior. In this work, tetraphenylethene (TPE)-phenylalanine derivatives, haracterized by...
application / peptides / unnatural amino acid
di emanuela erba · Published 3 Gennaio 2024 · Last modified 12 Settembre 2024
Structures composed of alternating α and β amino acids can give rise to peculiar secondary structural motifs, which could self-assemble into complex structures of controlled geometries. This work describes the self-assembly properties of an...
peptides / unnatural amino acid
di emanuela erba · Published 3 Gennaio 2024 · Last modified 26 Settembre 2024
A dimeric cyclic cysteine analogue, i.e. (1R,1’R,2R,2’R)-2,2’-disulfanediylbis (aminocyclohexane-1-carboxylic acid), was used as a constrained unnatural amino acid and as a folding inducer in ultra-short Leu-Val-containing peptide. Our results showed that both free dimer amino...
The design and synthesis of a series of peptide derivatives based on a short ACE2 α-helix 1 epitope and subsequent [i – i+4] stapling of the secondary structure resulted in the identification of a...
Accelerated molecular dynamics (aMD) protocols were assessed on predicting the secondary structure of eight peptides, of which two are helical, three are β-hairpins, and three are disordered. Protocols consisted of combinations of three force...
Surface functionalization of nanoparticles (NPs) with tumor-targeting peptides is an emerging approach with a huge potential to translate in the clinic and ameliorate the efficacy of nano-oncologicals. One major challenge is to find straightforward...
Temporin B (TB) is a 13-amino-acid-long, cationic peptide secreted by the granular glands of the European frog Rana temporaria. We recently showed that the modified TB peptide analog TB_KKG6K rapidly killed planktonic and sessile...
Temporins are short peptides secreted by frogs from all over the world. They exert antimicrobial activity, mainly against Gram-positive bacteria, including resistant pathogens; recent studies highlight other possible applications of these peptides as anticancer...
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