Amino acids, Peptidomimetics, peptides, protein InteractionS group
Protein–protein interactions (PPIs) have been recognized as a promising target for the development of new drugs, as proved by the growing number of PPI modulators reaching clinical trials. In this context, peptides represent a...
application / catalysis / peptides
di emanuela erba · Published 11 Settembre 2024 · Last modified 12 Settembre 2024
Self-assembled peptides are used for diverse applications in the biomedical and technological fields. The morphology and function of the assembled systems are dictated by the peptide sequence and length. In thiswork, a supramolecular catalyst...
Alpha-synuclein (αSyn) is a small presynapticprotein (14kDa) that is involved insynucleinopathies including Parkinson’sdisease (PD). In itsnativestate, theαSynmonomerexistsinanunfoldedstate,anditsfoldingishighlydependentonvariationsof environmental conditions,mutations and interactionswithendogenous and/orexogenousmolecules. Recently, there is increasingevidence for adirect interplaybetweenαSynandmicrotubules(MTs),whosedefectsarelinkedtoneurodegenerativediseases, suchasPD.Understanding thecorrelationbetweenαSynandMTscouldbefundamental forthecorrectcomprehensionoftheundergoingmechanismsofPD.Hence,wechemicallysynthesizeda library of...
di emanuela erba · Published 2 Maggio 2024 · Last modified 26 Settembre 2024
Supramolecular gels were developed by taking advantage of an assembly of small dipeptides containing pyrrolo-pyrazole scaffolds. The dipeptides were prepared through a robust and ecofriendly synthetic approach from the commercially available starting materials of...
Aggregation-induced emitting (AIE) luminophores are sensitive and easy-to-handle types of robes that allow driving a stimulus-responsive off/on optical tool through the manipulation of the aggregation behavior. In this work, tetraphenylethene (TPE)-phenylalanine derivatives, haracterized by...
application / nanofibers / Peptidomimetics
di emanuela erba · Published 8 Aprile 2024 · Last modified 26 Settembre 2024
We prepared a small library of short peptidomimetics based on 3-pyrrolo-pyrazole carboxylate, a non-coded γ-amino acid, and glycine or alanine. The robust and eco-friendly synthetic approach adopted allows to obtain the dipeptides in two...
di emanuela erba · Published 27 Marzo 2024 · Last modified 26 Settembre 2024
Though the bulk of the COVID-19 pandemic is behind, the search for effective and safea anti-SARS-CoV-2 drugs continues to be relevant. A highly pursued approach for antiviral drug development involves targeting the viral spike...
Apoptosis-inducing factor (AIF), which is confined to mitochondria of normal healthy cells, is the first identified caspase-independent cell death effector. Moreover, AIF is required for the optimal functioning of the respiratory chain machinery. Recent...
application / peptides / unnatural amino acid
di emanuela erba · Published 3 Gennaio 2024 · Last modified 12 Settembre 2024
Structures composed of alternating α and β amino acids can give rise to peculiar secondary structural motifs, which could self-assemble into complex structures of controlled geometries. This work describes the self-assembly properties of an...
The design and synthesis of a series of peptide derivatives based on a short ACE2 α-helix 1 epitope and subsequent [i – i+4] stapling of the secondary structure resulted in the identification of a...
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