Amino acids, Peptidomimetics, peptides, protein InteractionS group
The design and synthesis of a series of peptide derivatives based on a short ACE2 α-helix 1 epitope and subsequent [i – i+4] stapling of the secondary structure resulted in the identification of a...
Accelerated molecular dynamics (aMD) protocols were assessed on predicting the secondary structure of eight peptides, of which two are helical, three are β-hairpins, and three are disordered. Protocols consisted of combinations of three force...
Lysozyme (E.C. 3.2.1.17), an about 14 kDa protein and pI 11, widely spread in nature, is present in humans mainly in milk, saliva, and intestinal mucus as a part of innate defense mechanisms.It is...
Surface functionalization of nanoparticles (NPs) with tumor-targeting peptides is an emerging approach with a huge potential to translate in the clinic and ameliorate the efficacy of nano-oncologicals. One major challenge is to find straightforward...
Protein-mimetic peptides (PMPs) are shorter sequences of self-assembling proteins, that represent remarkable building blocks for the generation of bioinspired functional supramolecular structures with multiple applications.The identification of novel aminoacidic sequences that permit the access...
Alpha-synuclein (αSyn) is a small presynaptic protein (14 kDa) that is involved in synucleinopathies including Parkinson’s disease (PD). In its native state, the αSyn monomer exists in an unfolded state, and its folding is...
Protein aggregation into amyloid fibrils is the archetype of aberrant biomolecular selfassembly processes, with more than 50 associated diseases that are mostly uncurable.Understanding aggregation mechanisms is thus of fundamental importance and goes inparallel with...
Temporin B (TB) is a 13-amino-acid-long, cationic peptide secreted by the granular glands of the European frog Rana temporaria. We recently showed that the modified TB peptide analog TB_KKG6K rapidly killed planktonic and sessile...
Temporins are short peptides secreted by frogs from all over the world. They exert antimicrobial activity, mainly against Gram-positive bacteria, including resistant pathogens; recent studies highlight other possible applications of these peptides as anticancer...
application / unnatural amino acid
di emanuela erba · Published 10 Dicembre 2023 · Last modified 3 Gennaio 2024
We reported on the synthesis of new organocatalysts belonging to the class of ß-morpholine amino acids that were tested in a model reaction
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