Amino acids, Peptidomimetics, peptides, protein InteractionS group
Peptides and nucleic acids can self-assemble to give supramolecular structures that find application in different fields, ranging from the delivery of drugs to the obtainment of materials endowed with optical properties. Forces that stabilize...
di emanuela erba · Published 13 Aprile 2022 · Last modified 13 Maggio 2022
The analysis of the forces governing helix formation and stability in peptides and proteins has attracted considerable interest in order to shed light on folding mechanism. We analyzed the role of hydrophobic interaction, steric...
Temporin B (TB) is a short, positively charged peptide secreted by the granular glands of the European frog Rana temporaria. While the antibacterial and antiviral efficacy of TB and some of its improved analogs...
application / proteins / unnatural amino acid
di emanuela erba · Published 6 Aprile 2022 · Last modified 13 Maggio 2022
Alpha-synuclein (αSyn) is a highly expressed and conserved protein, typically found in the presynaptic terminals of neurons. Themisfolding and aggregation of αSyn into amyloid fibrils is a pathogenic hallmark of several neurodegenerative diseases called...
di emanuela erba · Published 19 Novembre 2021 · Last modified 21 Gennaio 2022
The aim was to investigate the role of the constrained AA, the anchor point (at C- or Nterminus) and the peptide length on their potential use as gold binding motif.
di emanuela erba · Published 4 Ottobre 2021 · Last modified 21 Gennaio 2022
Colloidal gold nanoparticles (GNPs) have found wide-ranging applications in nanomedicine due to their unique optical properties, ease of preparation, and functionalization. To avoid the formation of GNP aggregates in the physiological environment, molecules such...
application / Peptidomimetics / Review
di emanuela erba · Published 27 Settembre 2021 · Last modified 21 Gennaio 2022
Electrospinning is a well-known, straightforward, and versatile technique, widely used for the preparation of fibers by electrifying a polymer solution. However, a high molecular weight is not essential for obtaining uniform electrospun fibers; in...
The main goal in developing peptidomimetics is the stabilization of the bioactive conformation of peptides. Among all the secondary structures, turns are of paramount importance. This review highlights the recent advances in the design...
application / unnatural amino acid
di emanuela erba · Published 14 Aprile 2021 · Last modified 21 Gennaio 2022
The chemical structure of oligonucleotide analogues dictates the conformation of oligonucleotide analogue oligomers, their ability to hybridize complementary DNA and RNA, their stability to degradation and their pharmacokinetic properties. In a study aimed at...
Based on the supramolecular interaction between vancomycin (Van), an antibiotic glycopeptide, and D-Ala-D-Ala (DADA) dipeptides, a novel class of artificial metalloenzymes was synthesized and characterized. The presence of an iridium(III) ligand at the N-terminus...
Altro
comments