Amino acids, Peptidomimetics, peptides, protein InteractionS group
The development of mitochondria-targeting cell permeable vectors represents a promising therapeutic approach for several diseases, such as cancer and oxidative pathologies. Nevertheless, access to mitochondria can be difficult. A new hybrid material composed by...
application / unnatural amino acid
di emanuela erba · Published 2 Febbraio 2017 · Last modified 21 Gennaio 2022
An advanced intermediate in the synthesis of the racemic Neuraminidase inhibitor Peramivir was synthesised in a new and versatile manner starting from a stereoselective 1,3-dipolar cycloaddition reaction between the nitrile oxide deriving from 2-ethylbutanal...
study aimed to identify a new skin penetrating peptide (SPP) able to enhance unfractionated heparin (UFH) permeation through human epidermis by screening a phage display peptide library.
di emanuela erba · Published 7 Novembre 2016 · Last modified 21 Gennaio 2022
Chem. Sci., 2017, 8, 1295–1302 DOI: 10.1039/C6SC03176E Alzheimer’s disease is a neurodegenerative disorder linked to oligomerization and fibrillization of amyloid b peptides, with Ab1–42 being the most aggregative and neurotoxic one. We report herein...
application / unnatural amino acid
di emanuela erba · Published 11 Ottobre 2016 · Last modified 21 Gennaio 2022
RSC Adv., 2016,6, 90754-90759 DOI: 10.1039/C6RA17116H formation of supramolecular assembly is reported. The two diastereoisomeric pentapeptides AcAla- NRB-Ala-Aib-AlaNH2 1 and 2 containing the two enantiomers of non-proteinogenic norbornene amino acid (NRB) were synthesized in...
application / unnatural amino acid
di emanuela erba · Published 29 Agosto 2016 · Last modified 21 Gennaio 2022
RSC Adv., 2016,6, 71529-71533 DOI: 10.1039/C6RA16255J Taking inspiration from the Ctr-1 Mets7 Cu(I) binding motif, effective hybrid catalysts have been developed for asymmetric Henry condensations under green conditions. The introduction of an unnatural dipeptide...
FEBS Letters 590 (2016) 943–953 ª 2016 Federation of European Biochemical Societies doi:10.1002/1873-3468.12126 O-acetylserine sulfhydrylase (OASS), the enzyme catalysing the last step of cysteine biosynthesis in bacteria, is involved in antibiotic resistance and...
The Horizon 2020 MSCA joint doctoral project MoGlyNet (“Modulation of glycolytic flux as a new approach for treatment of atherosclerosis and plaque stabilization: a multidisciplinary study”) is run by a Consortium of Universities in...
application / unnatural amino acid
di emanuela erba · Published 4 Settembre 2015 · Last modified 21 Gennaio 2022
The synthesis and the structural characterization of dipeptides composed of unnatural fluorine-substituted β2,3-diarylamino acid and L-alanine are reported. Depending on the stereochemistry of the β amino acid, these dipeptides are able to self-assemble into proteolytic stable nanotubes....
The theoretical basis behind the ability of constrained Cα-tetrasubstituted amino acids (CTAAs) to induce stable helical conformations has been studied through Replica Exchange Molecular Dynamics, Potential of Mean Force and Quantum Theory of...
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