PhD student profile, Nicola Mangieri

PhD Student:  Nicola Mangieri

Tutor: Claudia Picozzi – Department of Food, Environmental and Nutritional Sciences (DeFENS)

Dean: Prof. Ella Pagliarini

Research area: Food Science and Nutrition

Research topic

Foodborne emerging pathogens: in depth analysis on non-O157 Shiga toxin-producing Escherichia coli

Project Synopsis

My PhD project is based on the study of virulence factor of Shiga toxin-producing Escherichia coli (STEC) and the use of bacteriophage to control STEC strains in food. STEC is a food- and waterborne pathogen that can cause severe outbreaks in humans. The O157 is the most common serotype followed by O103, O145, O91, O111 and O146, the so-called non-O157. Due to the increasing in antibiotic-resistance, the phage therapy for STEC could be a valid alternative for pathogen control. One of the aims of the project is to obtain a cocktail of phages capable to control STEC strains, which could then be used on ready-to-eat (RTE) foods.

Project keywords

Food pathogens, STEC, bacteriophages

Contacts

Department of Food, Environmental and Nutritional Sciences (DeFENS; Via Mangiagalli 25, Milano, 4^th floor, lab 4018)

nicola.mangieri@unimi.it

Sponsor

Fellowship sponsor: Università degli Studi di Milano

Publications

Peer reviewed

Beccalli M., Picozzi C., Mangieri N., Vigentini I. and Foschino R. (2019). Assessment of Microbial Populations in the Manufacture of Vacuum-Packaged Ready-to-Eat Roast Beef and in a Related Production Plant. Journal of Food Protection, Vol. 82, No. 1, pp 58–64 doi: 10.4315/0362-028X.JFP-18-147

Cordero-Bueso G., Mangieri N., Maghradze D., Foschino R., Valdetara F., Cantoral J. M. and Vigentini I. (2017). Wild Grape-Associated Yeasts as Promising Biocontrol Agents against Vitis vinifera Fungal Pathogens. Frontiers in Microbiology; 8: 2025.  doi: 10.3389/fmicb.2017.02025

Communications to congress

Mangieri N., Bacteriophage application to control non-O157 Shiga-toxin producing Escherichia coli. XXIII Workshop on the Developments in the Italian PhD Research on Food Science, Technology and Biotechnology. Oristano, Italy, 19-20 September, 2018. ISBN 978-88-907678-6-9 (Poster).

Mangieri N., Foschino R. and Picozzi C., Can the induction of stx phages be influenced by stressors in cheese-making process? 10th International symposium on Shiga toxin (Verocytotoxin) Producing Escherichia coli Infections. Firenze, Italy, 6-9 May, 2018 (Poster).

Picozzi C., Mangieri N., Antoniani D., Vigentini I. and Foschino R., Different occurence of biofilm producing STEC in dairy and human isolates. 4th International Conference on Microbial Diversity. Bari, Italy, 24-26 October 2017 (Poster).

Cordero-Bueso G., Vigentini I., Foschino R., Maghradze D., Mangieri N. and Cantoral J. M., Wild Grape-Associated Yeasts as a Promising Strategy of Biocontrol against Vitis vinifera Fungal Pathogens. 7th Congress of European Microbiologists (FEMS). Valencia, Spain, 9-13 July, 2017 (Poster).