PhD Student: Viola Termine (ORCID n. 0009-0004-3560-2535)
Supervisor: Prof. Diego Mora
Co-tutor: Dr. Stefano Colombo (Beingpharma Srl)
Dean: Prof. Diego Mora
Research area: Food Science and Nutrition
Research topic
Probiotics and food associated microorganisms: ecology, molecular and functional characterization, impact on host health
Project Synopsis
Probiotics are defined as live organisms, which when administered in sufficient amounts, can have a beneficial effect on the host’s health. On the market there are different forms of probiotics preparations, and the current tendency is choosing multi-strain probiotics. In fact, they might be more beneficial than many single-strain probiotics in restoring gut dysbiosis, thanks to synergistic effects of different strains in the mixture. With this considered, the first aim of my PhD project consists in deeply investigating the aetiology of the efficacy of commercial multi-strain probiotic formulations. This will be performed at first by performing an in vitro screening of probiotic properties of single strains of a commercial multi-strain probiotic product, its isolated cellular components and supernatants. In parallel, the same approach will be adopted with the same inactivated product to corroborate considerable published evidence that inactivated probiotic preparations and their metabolites can also exert relevant biological responses.
Project keywords
Microbiology; multi-strain probiotic formulations; gut microbiota; gut health
Contacts
University of Milan, Department of Food, Environmental and Nutritional Sciences (DeFENS), Division of Food Microbiology and Bioprocesses, Via Mangiagalli 25, 20133 Milan, Italy
viola.termine@unimi.it
Collaborations
Prof. Diego Mora
Prof.ssa Federica Facciotti
Institutions: Università degli Studi di Milano (UNIMI); Università degli Studi di Milano – Bicocca
Dr. Stegano Colombo
Institution:
Beingpharma Srl
Sponsor
Fellowship sponsor: Università degli Studi di Milano, Beingpharma S.r.l.
Project sponsor: Beingpharma S.r.l.
Others
Linkedin: http://www.linkedin.com/in/viola-termine-456bb5266
Why might multi-strain probiotics be more effective than single-strain ones in treating gut dysbiosis? Thanks for information Kehidupan Kampus
According to a recent review that investigates the effectiveness of multi-strain probiotics in comparison to those of single-strains probitoics, multi-strain probiotics might be more helpful in treating gut dysbiosis thank to a synergistic effect among the individual isolates. This results in a high adhesion to the mucosae and in a consequent reduction of pathogens’ colonization of intestinal surface (Kwoji et al., 2021).
Moreover, studies in vitro and in animal models have shown that multi-strain probiotics can enhance intestinal barrier functions and the expression levels of cytokines involved in intestinal mucosal immunity more effectively than single-strain probiotic treatments (di Vito et al., 2022; Deng et al., 2013).
Another important aspect is that multi-strain probiotics could lead to a more drastic and diversified gut microbiome modulation than single-strain probiotics administration, helping to restore a more balanced gut microbiotia (He at al., 2021).
In the hope of having been clear, I remain at your disposal for any further clarification.
Thank you in advance for your attention.
Best regards,
Viola Termine