PhD student profile, Chiara Artale

PhD Student:  Chiara Artale (ORCID n. 0009-0000-2940-7048)

 

Supervisor: Dr. Simone Perna – DeFENS-Department of Food, Environmental and Nutritional Sciences

Co-tutor:  Prof. Patrizia Riso-DeFENS-Department of Food, Environmental and Nutritional Sciences

Dean: Prof. Diego Mora

Research area: Food Science and Nutrition

Research topic: Bioavailability and biological activity of dietary compounds/patterns and their role on human health

Project Synopsis

Exploring Hesperidin Metabolites in aging. Their Impact on Neuronal and Natural Killer Cells

My PhD project delves into the captivating effects of hesperidin, a potent polyphenol found in citrus fruits, on neuronal cells and Natural Killer (NK) cells. This research uncovers critical pathways related to aging, neuroprotection, and immune response, highlighting hesperidin’s potential to combat age-related cognitive decline and neurodegenerative diseases. By examining how hesperidin metabolites influence neuronal and immune health, I seek to reveal their roles in modulating oxidative stress, enhancing mitochondrial function, and promoting neurogenesis. These metabolites may also strengthen cellular resilience against age-related damage by reducing inflammation and supporting essential repair processes. A particularly intriguing aspect of the project is the exploration of NK cells in the neuronal environment, as their functionality declines with age, contributing to neuroinflammation. The findings may demonstrate how hesperidin can enhance NK cell activity and reduce inflammation, offering exciting insights into its therapeutic potential for improving brain health as we age.

Project keywords: immunosenescence, neuroprotection, polyphenols, citrus fruits

 

Contacts

Laboratory address:  University of Milan “La Statale”
DeFENS-Department of Food, Environmental and Nutritional Sciences 
Via Celoria 2 – 20133 Milan 

Email address:  chiara.artale@unimi.it

 

Collaborations

 

Sponsor

University of Milan, piano di sostegno alla ricerca (PSR) 2023 Linea 4

 

 

 

Publications

Poster presentation, 7th European Congress of Immunology (ECI) in Dublin from September 1st-4th 2024

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